Where to begin.....
So, one of the items you posted was the same study that I used. In that same study; there are only 2 examples of medications containing BOTH an oil and ethanol for injection. One of them is propofol for IV infusion/bolus injection; and the other is fulvestrant for IM injection. These 2 examples using ethanol and oil, out of a multitude of listed solvent-cosolvent medications, allows deduction that the practice is niche at best.
Furthermore propofol, one of the medications listed, is an emulsion which must be shaken before administration.
My question was not CAN ethanol be used; but rather WHY would ethanol be used in IM oil based injections?
You mention that the concentrations are so low that it is miscible in oil. I believe that this is incorrect because:
1) one of the medications is an emulsion therefore removing any comparison to properties of solution.
2) the other medication also contains benzyl benzoate and benzyl alcohol, suggesting that the ethanol is not sufficient as a single solvent for the medication.
Additionally, how could one have the slightest clue how much ethanol these companies use?
Now in the case of fulvestrant, I could see if they needed an additional cosolvent to dissolve the active ingredient. According to the chart for that medication; benzyl benzoate and benzyl alcohol are already at maximum approved concentrations. It appears that the manufacturer turned to ethanol as a last result when the other cosolvents failed to maintain solution.
This begs the question: why max out on BB and BA
if cosolvent with ethanol for injection is a good practice.
In the case of the vials that I and
@Jeffg353 posted, it appears that the manufacturer used ethanol
instead of benzyl benzote.
I do not intend to be argumentative; but I feel like I need to know why these 2 labs use ethanol.
Some of the other links you posted were all but irrelevant to the question at hand because the focus was oral elixir, suspension, or solution.
I have devoted most of the last year in research on the topic of using and making my own AAS; so I am particular about which pieces of information I consider valid.
The excerpt about ethanol causing muscle tissue destruction was not theory; but tested on rats.
I really appreciate your help and the challenge to my way of thinking; but I spent a lot of time reading what you posted and got absolutely no helpful information that I didn't use already in my initial post.
