CagriSema's going nowhere: a cautionary tale

[Ghoul]

Despite very promising initial results, as the clinical trials expanded, it looks increasingly mediocre. Very late in development for this disappointment to be revealed by Novo, but a reminder drug developers don't *have* to deliver bad news until they decide to. It's only required if they are putting the drug on the market.

With no release date yet revealed by Eli, I wonder what surprises await us with Reta.

IMO, those new to GLPs would be better off staying on the beaten path with proven winners, and keeping a large chunk of cash in their pockets, choosing Sema or Tirz. You can always upgrade later.

https://www.cnbc.com/2025/03/10/novo-nordisk-shares-fall-after-cagrisema-weight-loss-drug-trial-result.html

 

[noteablequotable]

I think in this landscape where price and access continue to be hot topics CagriSema has value. If it's only as effective as Tirzepatide that's good enough for a doctor to prescribe it when Tirz is unavailable or more expensive/not covered by insurance.

I've also heard some rumblings that CagriSema is more effective in people who have metabolic issues (I think one of the people who mentioned this was Lyle). If that's the case it may be even more valuable for that particular demographic. Maybe I should call Novo and yell at them

 

[SnowyMiami]

Do you think Cagri solo has a future for people that just want a decrease in food noise and don't want to deal with constipation/nausea?

 

[Ghoul]

Do you think Cagri solo has a future for people that just want a decrease in food noise and don't want to deal with constipation/nausea?

I'm sure Novo will make some use of it if there's any justifiable reason to do so. If they can it and walk away from tens or hundreds of millions in development costs that's a pretty good sign. it wasn't worth it.

 

[AlexDavis43]

Do you think Cagri solo has a future for people that just want a decrease in food noise and don't want to deal with constipation/nausea?

There are a few studies on pramlintide, another amylin agonist, alone and in combination with metreleptin (a leptin analog). Looked promising but fell off the radar.

 

[quarter]

Cagri was a huge bust for me (i know n=1). Just exhaustion in a vial

 

[SBD1]

Tirz give me tummy aches and works so well at killing my appetite I struggle to eat until the blood levels stop falling a few days post injection.

Reta is amazing low dose. I’ll take my chances, better quality of life. For now.