Caps or suspension?

[notanothersnake]

Even the pharmaceutical companies agree they're not 100% accurate. My system came from a pharmaceutical video.

I agree, nothing is 100% accurate. I think most of us do their best to achieve as close to perfect as we can.

 

[master.on]

Very similar to the system i use. The difference is with each addition of filler i mix the two powders by folding the mix over and over again with a thin credit card. It's the most accurate way to mix powders that I've found.

I dont use a colorant, but not a bad idea.

What i mean is this. I weigh out my active ingredient and add to mixing bowl. I then weigh out my filler and put to the side. I will then have 5 grams of active ingredient vs approximately 60 grams of filler. I'll pour an equal amount of filler to the amount of active ingredient (so if you have 5 grams of active ingredient i will eyeball approximately 5 grams of filler and pour on top). I'll then take a thin card (something like a credit card but thinner) and scoop under the powders in the bowl and kind of just flip it on top of it's self. Kind of like you would food in a pan with a spatula. But as i flip it over i spin the bowl little spins as i flip over and over again. Maybe like 8 times and then i add another equal amount, which is now about 10 grams of filler since you have 10 grams in the bowl, and repeat the flipping and spinning 8 times and do this process until the filler has all been applied and mixed. That's what the person in the video is doing accept instead of mixing he's motar and pestling. I think my way is better. I only mortar and pestle when there are clumps in the powder.

Which harmless colorants you'd use?
I saw Curcumin and other colored finely ground species in the supermarket.
Problem is I don't know shit about species or advanced cooking lol!

I don't think shaking a jar would get it fully mixed. It would he better than blending as I've heard some people do. See, you need an inconsistent form of mixing as these powders are not the same no matter how similar they are. If you have a consistent form of mixing, like a blender which spins in a consistent manner, then the powders will follow a path in a consistent way to its self. Kind of hard to explain. The filler will take it's own path and the active ingredient will follow it's own path.

Big parma uses rotating tumblers
some odd-shaped

They need to run at slow rpms, just 10-25 rpm
http://alfresco.ubm-us.net/alfresco_images/pharma/2014/08/22/c3495c71-6c68-44d2-926b-1be1fe5b3bbf/article-150852.pdf
MAXIBLEND 1-2-3 | Pharmaceutical Lab Blenders | GlobePharma

Before getting into dedicated industrial motors, what slow turning, continuous use appliance would you hack for its motor?
Cordless screwdrivers can turn slow, but I don't think they will stand 30 minutes of continuous use without overheating.

I have a bunch of powders that i buy from purebulk. I mostly use creatine or vitamin c, but the important thing is finding something with close to ths same size and weight. something that closely resembles the active ingredient if you will. And some products don't seem to work in liquid form such as caber. I find that a good number of people say cialis doesn't work when in liquid.

Scientific study shows 1% Acetic acid makes liquid Caber stable
Scientific study shows liquid Cabergoline recipe is stable for 36+ days!

Even the pharmaceutical companies agree they're not 100% accurate. My system came from a pharmaceutical video.

Capsule fill weight varies a bit, even with big pharma equipment and procedures
Weight and weight uniformity of hard gelatin capsules filled with microcrystalline cellulose and silicified microcrystalline cellulose. - PubMed - NCBI

 

[XKawN]

Which harmless colorants you'd use?
I saw Curcumin and other colored finely ground species in the supermarket.
Problem is I don't know shit about species or advanced cooking lol!


Big parma uses rotating tumblers
some odd-shaped

They need to run at slow rpms, just 10-25 rpm
http://alfresco.ubm-us.net/alfresco_images/pharma/2014/08/22/c3495c71-6c68-44d2-926b-1be1fe5b3bbf/article-150852.pdf
MAXIBLEND 1-2-3 | Pharmaceutical Lab Blenders | GlobePharma

Before getting into dedicated industrial motors, what slow turning, continuous use appliance would you hack for its motor?
Cordless screwdrivers can turn slow, but I don't think they will stand 30 minutes of continuous use without overheating.


Scientific study shows 1% Acetic acid makes liquid Caber stable
Scientific study shows liquid Cabergoline recipe is stable for 36+ days!


Capsule fill weight varies a bit, even with big pharma equipment and procedures
Weight and weight uniformity of hard gelatin capsules filled with microcrystalline cellulose and silicified microcrystalline cellulose. - PubMed - NCBI

Yes sir, seen these tumblers before. They also work by using an inconsistent tumbling method. The more consistent you are the more the different powders with thier different molecular sizes and weights will seperate. They will follow thier own path. Imagine how much material you will be mixing with those machines. Not necessary for home use or even small lab use. As for die, i would have thought i would use my regular filler and die then dry and sift it. That way I'm still using my filler oc choice with the molecular size and weight of choice. As for capsule fill weights, i use the same fillers with the same active ingredients and have filled and weighed capsules and have all my weghts of products needed to fill each capsule with each different active ingredient and each different filler written down. Not that i need it because it's all in my head anyways. I can say (off the top of my head) anavar with vitamin c as a filler in a type 0 capsules times 100 at 50mg per capsule that I'll need 5 grams anavar and 66 grams vitamin c.

 

[master.on]

Yes sir, seen these tumblers before. They also work by using an inconsistent tumbling method. The more consistent you are the more the different powders with thier different molecular sizes and weights will seperate. They will follow thier own path. Imagine how much material you will be mixing with those machines. Not necessary for home use or even small lab use. As for die, i would have thought i would use my regular filler and die then dry and sift it. That way I'm still using my filler oc choice with the molecular size and weight of choice. As for capsule fill weights, i use the same fillers with the same active ingredients and have filled and weighed capsules and have all my weghts of products needed to fill each capsule with each different active ingredient and each different filler written down. Not that i need it because it's all in my head anyways. I can say (off the top of my head) anavar with vitamin c as a filler in a type 0 capsules times 100 at 50mg per capsule that I'll need 5 grams anavar and 66 grams vitamin c.

Studies show manual blending works good enough

Mortar and pestle works fine as it grinds large particles to match small particle size
Evaluation of the degree of mixing of combinations of dry syrup, powder, and fine granule products in consideration of particle size distribution u... - PubMed - NCBI

Mortar and pestle requires 60-80 rotations, alternating clockwise and counterclockwise rotations, 10 each.
It matches or even beats expensive planetary mixing equipment

A Novel Blending Method for Dispensing Powdered Medicine
Evaluation of Degree of Blending Colored Diluents Using Color Difference Signal Method


@XKawN
What do you think about the stable liquid caber study?
Stability of cabergoline in fox baits in laboratory and field conditions
(click on the upper right-hand corner blue blox 'Download full-text PDF' to read the entire study)

 

[XKawN]

Studies show manual blending works good enough

Mortar and pestle works fine as it grinds large particles to match small particle size
Evaluation of the degree of mixing of combinations of dry syrup, powder, and fine granule products in consideration of particle size distribution u... - PubMed - NCBI

Mortar and pestle requires 60-80 rotations, alternating clockwise and counterclockwise rotations, 10 each.
It matches or even beats expensive planetary mixing equipment

A Novel Blending Method for Dispensing Powdered Medicine
Evaluation of Degree of Blending Colored Diluents Using Color Difference Signal Method


@XKawN
What do you think about the stable liquid caber study?
Stability of cabergoline in fox baits in laboratory and field conditions
(click on the upper right-hand corner blue blox 'Download full-text PDF' to read the entire study)

It just doesn't stay stable long enough. By the time a source makes it and sells it it's already garbage. Wish it would stay longer.

 

[master.on]

It just doesn't stay stable long enough. By the time a source makes it and sells it it's already garbage. Wish it would stay longer.

Maybe they are missing 1% Acetic Acid as to replicate the study findings?

There was no loss of cabergoline from solutions in 1% acetic acid when stored in the refrigerator at 4°C or at room temperature for up to 36 days.
After 14 months’ storage at 4°C, however, the concentration of
cabergoline in solution had fallen by 50%.
Stability of cabergoline in fox baits in laboratory and field conditions

IMO it would be better to use distilled water to avoid residues that might degrade Caber.

 

[AnTabolic73]

I can't bring myself to try the geometric dilution or whatever it's called. I've seen it done on video, but they used a white powder and a red powder and ended up with a pinkish powder. That's cool but what about when you have 2 white powders? And even if I were to get the mixing part right. The way my capsule machine works how would I ensure that each capsule has the same amount of powder? Do I tamp it down? Do I not tamp it down? Do I weigh the empty capsule and then the full capsule to ensure it's consistent. I've weighed empty capsules and they vary by 5 or so mg within the same batch of caps. Not enough to make a huge difference but enough to drive me crazy.

The way I cap it's tedious but I feel more comfortable doing it this way. And know that it's fairly accurate or at least accurate enough to not bother me.

I have these little antistatic measuring spoons, they hold anywhere from 8mg to 12mg of material depending on the size of the powder. I take my raws I scoop up a little(usually 2 scoops I usually aim for 20mg caps) I throw it into a .001 scale to just visually see what 20 to 25mg looks like. Once I have a decent enough idea what it looks like I load up my capsule machine and just scoop the desired amount. Now like I said, it's tedious but I feel like it works for me. I then fill it with whatever (creatine mostly) tamp it down fill it some more then put then together. I made about 144 var (machine loads 24 caps at a time, so six go arounds) caps the other day. Took a couple hours, but that's for 8 weeks of var.

Now the caps may be off slightly. I may accidently grab what would be considered a "heaping" spoonful vs a leveled spoonful, or I might have some raws that are sitting on the long part of the spoon and not the actual scoop part. But I can't imagine it being off by more than 5 or 10mg if that.

If I were making it for my girl lets say, if probably just go the solution route and use 100% Everclear, and as little raws as I can get to dissolve. Just got accuracy sake. But for me. If I'm accidentally taking 25mg of var instead of 20, or 17mg instead of 20 I don't think it'll make or break me.

 

[AnTabolic73]

These are the ones I use, the fit perfectly into my size 1 caps, and they are squared in the part you hold so it's easy to handle and the just with a roll of the fingers you drop the product in


Call me crazy but this is how I cap, it ain't all scientific but fuck it, it works.

 

[Sergio9282]

How much acetic acid and distilled water do I need for a gram of cabergoline?

 

[Ridethelightningbarefoot]

I had some var that I measured and filled by hand into caps! It was a mother fucker but at least I knew what was in there!

 

[Sergio9282]

I had some var that I measured and filled by hand into caps! It was a mother fucker but at least I knew what was in there!

Its just difficult to measure 0.25mg of Cabergoline, to then just put it in a capsule. I think putting it in a suspension will be much easier.