Chinese HGH - Clear or Cloudy

[madcap71]

A brand new bac water
Completely at room temperature was used
And it was entirely the same afterwards

ah yeah, fair enough then!

 

[Ghoul]

Thank you for your responses
So if I filter the cloudy HGH
Will it still hold the value of 10ui
Or has that degraded and it’s lower now ?

Odds are the amount of aggregated, inactive rHGH, unless it looks like milk, isn’t more than 10%, more likely low single digits. Worst case scenario I’ve seen are scientists using very high heat getting about 30% loss via aggregation. Since most are overdosed I don't think any dose adjustment needs to be made.

As far as “is it ok to inject after filtration?”.

For my risk tolerance yes.

Aggregates need to fall within a certain “looks like bacteria!” size range for the immune system to react and cause immunogenicity.

Thats 0.1 µm to 10 µm.

Aggregates must be at least 100um in size to be visible by the way, so relatively huge. (Those large aggregates cause other issues, but I’m focused on immunogenicity as the biggest threat).

So a .22um filter is removing 99% of the aggregates in the immunogenicity triggering size range. The small amount left is probably on par with the levels found in pharma (or even less, to be honest).

This experiment was conducted by one of the worlds leading experts on peptide pharmaceutical development to demonstrate why even pharma peptides / proteins should be filtered, in part, to avoid immunogenicity causing drugs to become less effective:

Here’s the result of pharma* rHGH filtered with .22um PES syringe filters, the same type I use.

From 37,000 >1um sized particles / ml down to about 300.



This was expired rHGH, and shaken, to simulate worst case scenario of what a patient might be exposed to with poorly stored and handled pens. Pretty sure it’s safe to assume UGL is always “worst case scenario” condition.

So knowing filtering completely neutralizes the aggregate threat, and the cumulative harm from all the other shit found in cheap vials being injected on a daily basis,



along with guaranteeing sterility since Jano found a high proportion of peptide vials containing bacteria, a shock, I know, when most are likely produced in peptide labs like this one:



that doesn’t make UGL peptides risk free, but lowers it enough to make it tolerable for me.

 

[Tobman]

Odds are the amount of aggregated, inactive rHGH, unless it looks like milk, isn’t more than 10%, more likely low single digits. Worst case scenario I’ve seen are scientists using very high heat getting about 30% loss via aggregation. Since most are overdosed I don't think any dose adjustment needs to be made.

As far as “is it ok to inject after filtration?”.

For my risk tolerance yes.

Aggregates need to fall within a certain “looks like bacteria!” size range for the immune system to react and cause immunogenicity.

Thats 0.1 µm to 10 µm.

Aggregates must be at least 100um in size to be visible by the way, so relatively huge. (Those large aggregates cause other issues, but I’m focused on immunogenicity as the biggest threat).

So a .22um filter is removing 99% of the aggregates in the immunogenicity triggering size range. The small amount left is probably on par with the levels found in pharma (or even less, to be honest).

This experiment was conducted by one of the worlds leading experts on peptide pharmaceutical development to demonstrate why even pharma peptides / proteins should be filtered, in part, to avoid immunogenicity causing drugs to become less effective:

Here’s the result of pharma* rHGH filtered with .22um PES syringe filters, the same type I use.

From 37,000 >1um sized particles / ml down to about 300.

View attachment 357594

This was expired rHGH, and shaken, to simulate worst case scenario of what a patient might be exposed to with poorly stored and handled pens. Pretty sure it’s safe to assume UGL is always “worst case scenario” condition.

So knowing filtering completely neutralizes the aggregate threat, and the cumulative harm from all the other shit found in cheap vials being injected on a daily basis,

View attachment 357596View attachment 357595

along with guaranteeing sterility since Jano found a high proportion of peptide vials containing bacteria, a shock, I know, when most are likely produced in peptide labs like this one:

View attachment 357597

that doesn’t make UGL peptides risk free, but lowers it enough to make it tolerable for me.

Thank you for the response and time taken
It is appreciated

 

[lilhawk]

Did you not agree with the answer you got on UKM? It's likely because you had your BAC water in the fridge

I have kept BAC water in the fridge and never had it cause a vial of serostim to be cloudy. The OP has junk GH plain and simple.

 

[Mushy404]

I have kept BAC water in the fridge and never had it cause a vial of serostim to be cloudy. The OP has junk GH plain and simple.

I didnt even know it wasn't supposed to be in the fridge

 

[Ghoul]

I didnt even know it wasn't supposed to be in the fridge

It’s not.

Not necessary. I doubt it’ll hurt anything, but it’s not needed,

 

[baht]

It won't hurt it. You store bacteriostatic water in the fridge after opening

 

[xeonmasters]

i tested a batch of JY that was very cloudy, one of the worst side effects i've ever had

 

[Tobman]

i tested a batch of JY that was very cloudy, one of the worst side effects i've ever had

So you pinned cloudy I presume, what happened?

 

[BigDadd7]

So you pinned cloudy I presume, what happened?

Grew a third testicle

 

[Ghoul]

Grew a third testicle

No he wanted to know if anything *bad* happened.

 

[BigDadd7]

No he wanted to know if anything *bad* happened.

It was on his forehead?

 

[xeonmasters]

So you pinned cloudy I presume, what happened?

got a instant boner

just kidding, massive water retention, I didn't feel the "good effects" of HGH like deep sleep, I just felt like I was using a weak GHRP (without the hunger), I stopped using HGH and lost 5kg in 36 hours

i've used many brands (some of them straight from manufacturer like qijianbio), and I never had cloudy hgh. I tried reconstituting it with more water, i used around 250ui, just pure garbage

 

[xeonmasters]

Odds are the amount of aggregated, inactive rHGH, unless it looks like milk, isn’t more than 10%, more likely low single digits. Worst case scenario I’ve seen are scientists using very high heat getting about 30% loss via aggregation. Since most are overdosed I don't think any dose adjustment needs to be made.

As far as “is it ok to inject after filtration?”.

For my risk tolerance yes.

Aggregates need to fall within a certain “looks like bacteria!” size range for the immune system to react and cause immunogenicity.

Thats 0.1 µm to 10 µm.

Aggregates must be at least 100um in size to be visible by the way, so relatively huge. (Those large aggregates cause other issues, but I’m focused on immunogenicity as the biggest threat).

So a .22um filter is removing 99% of the aggregates in the immunogenicity triggering size range. The small amount left is probably on par with the levels found in pharma (or even less, to be honest).

This experiment was conducted by one of the worlds leading experts on peptide pharmaceutical development to demonstrate why even pharma peptides / proteins should be filtered, in part, to avoid immunogenicity causing drugs to become less effective:

Here’s the result of pharma* rHGH filtered with .22um PES syringe filters, the same type I use.

From 37,000 >1um sized particles / ml down to about 300.

View attachment 357594

This was expired rHGH, and shaken, to simulate worst case scenario of what a patient might be exposed to with poorly stored and handled pens. Pretty sure it’s safe to assume UGL is always “worst case scenario” condition.

So knowing filtering completely neutralizes the aggregate threat, and the cumulative harm from all the other shit found in cheap vials being injected on a daily basis,

View attachment 357596View attachment 357595

along with guaranteeing sterility since Jano found a high proportion of peptide vials containing bacteria, a shock, I know, when most are likely produced in peptide labs like this one:

View attachment 357597

that doesn’t make UGL peptides risk free, but lowers it enough to make it tolerable for me.

i've offended you before, and yes, you're right. Thanks for the post.

Sponsored by:

 

[KOArtist]

I’m pretty sure I bought all the right stuff to filter, just haven’t tackled it just yet. Any “Peptides filtering for dummies” vids on YT possibly?

 

[Ghoul]

I’m pretty sure I bought all the right stuff to filter, just haven’t tackled it just yet. Any “Peptides filtering for dummies” vids on YT possibly?

There are a number of them, none are that great but you’ll get the basics and can develop your own technique from there. Consider a practice run pretending an empty vial is lyophilized, so you don’t end up wasting a vial due to some accident.

This essentially covers it. I use 3ml syringes, and a single 25g 1.25” needle for all steps. A large gauge needle is preferable to keep pressure, and therefore shear stress low, which can damage some peptides.



View: https://youtu.be/fmz4241qPn4

 

[Tobman]

A 0.22um filter did turn it clear

 

[misleaded]

A 0.22um filter did turn it clear
View attachment 358473

pin it and tell it how it goes lol