Cloudy hgh on 0,5ml bac water

[LeeroyMatinta]

I mixed 10 IU of HGH with 0.5 ml of bac water instead of 1 ml. Does the smaller amount of water affect how long it stays stable?

 

[Juiced_lizard]

I mixed 10 IU of HGH with 0.5 ml of bac water instead of 1 ml. Does the smaller amount of water affect how long it stays stable?

I’m sure it’s cloudy because it needs more bac water. The amount of bac water doesn’t make it less stable. Assuming you are using good bac water.

 

[Ateam2023]

from my "research" and some things i learned reading @Ghouls posts, is its more likely to get "aggregates" when using a smaller amount of bac water to reconstitute hgh/peptides, properly diluted hgh/peptides can reduce aggregates,,,,,

 

[Ghoul]

The more concentrated a protein solution the more prone it is to aggregation formation. Once reconstituted proteins don't crash the way AAS do.

Was it clear when you initially added BAC?

 

[LeeroyMatinta]

The more concentrated a protein solution the more prone it is to aggregation formation. Once reconstituted proteins don't crash the way AAS do.

Was it clear when you initially added BAC?

Yes, it was more clear. They are cloudy, not very cloudy, but theres a visible difference if using 1ml vs 0.5ml per 10iu. Do you think for my 24iu vials which should come 1,2ml would be enough?

 

[Ghoul]

Yes, it was more clear. They are cloudy, not very cloudy, but theres a visible difference if using 1ml vs 0.5ml per 10iu. Do you think for my 24iu vials which should come 1,2ml would be enough?

The most concentrated commercial rHGH I've found is .05ml per iu. But that's with excipients that prevent aggregation, which UGL doesn't have. That would be .5ml for 10iu but obviously that's not enough for the formulation you have.

Once aggregates form, adding more water makes them less visible, but they're still there.

You can't overdilute peptides. The more BAC the better for HGH(not for all peptides, as pharmacokinetics come into play, ie, the speed at which the drug is absorbed, but that doesn't apply to HGH).

So if .5ml is insufficient for 10iu, assuming the same supplier, for the 24iu vial I would add 3ml. If dose is larger than 8iu, ie, 12iu, then limit it to 1ml per dose, in this example 2ml.

This is because of another factor, you don't want subQ injections over 1ml.

Avoiding over concentrated HGH and aggregate formation will reduce immune response, minimize anti-GH Antibody formation, and potentially give you a better result, especially long term.

 

[Ateam2023]

Yes, it was more clear. They are cloudy, not very cloudy, but theres a visible difference if using 1ml vs 0.5ml per 10iu. Do you think for my 24iu vials which should come 1,2ml would be enough?

are you trying to reduce the volume of injection by lowering the amount of bac water your reconstituting with?

 

[Ateam2023]

The most concentrated commercial rHGH I've found is .05ml per iu. But that's with excipients that prevent aggregation, which UGL doesn't have. That would be .5ml for 10iu but obviously that's not enough for the formulation you have.

Once aggregates form, adding more water makes them less visible, but they're still there.

You can't overdilute peptides. The more BAC the better for HGH(not for all peptides, as pharmacokinetics come into play, ie, the speed at which the drug is absorbed, but that doesn't apply to HGH).

So if .5ml is insufficient for 10iu, assuming the same supplier, for the 24iu vial I would add 3ml. If dose is larger than 8iu, ie, 12iu, then limit it to 1ml per dose, in this example 2ml.

This is because of another factor, you don't want subQ injections over 1ml.

Avoiding over concentrated HGH and aggregate formation will reduce immune response, minimize anti-GH Antibody formation, and potentially give you a better result, especially long term.

i agree 100% , for example i have a 17 iu vial that i reconstitute with 1.7 ml of bac water and i have no issues with cloudiness or particulate (aggregation) floating etc,,,,, Granted it is a "larger" injection volume, but its not to much to worry about and i also include 2-3 other peptides "at times" in same syringe/injection so it is manageable,,,,,

 

[thejumpingsheep]

Ive seen cloudiness with HGH from QSC. But I used it and it definitely still worked. I was 2iu a day and it boosted my IGF-1 a lot and I even had it mixed with BPC/TB/GHK-CU.

 

[muragost]

Ive seen cloudiness with HGH from QSC. But I used it and it definitely still worked. I was 2iu a day and it boosted my IGF-1 a lot and I even had it mixed with BPC/TB/GHK-CU.

is the ghk cu good from HYB

 

[lilhawk]

I mixed 10 IU of HGH with 0.5 ml of bac water instead of 1 ml. Does the smaller amount of water affect how long it stays stable?

No. I mix 18iu of Serostim with 1/2 ml of water and it's perfectly clear every time.

 

[brutalbuilt]

The more concentrated a protein solution the more prone it is to aggregation formation. Once reconstituted proteins don't crash the way AAS do.

Was it clear when you initially added BAC?

when i first add bac water its cloudy but after mixing its clear.. is that fine?

 

[Ghoul]

when i first add bac water its cloudy but after mixing its clear.. is that fine?

Yeah, as long as it doesn't go from clear back to cloudy.

 

[AlexDavis43]

No. I mix 18iu of Serostim with 1/2 ml of water and it's perfectly clear every time.

Cloudiness doesn't necessarily indicate reduced stability. Sometimes it starts cloudy and clears up with time or gentle swirling.

Peptides wouldn't become more stable with time or gentle swirling, as would be the case if cloudiness indicated reduced stability.

 

[Ghoul]

Cloudiness doesn't necessarily indicate reduced stability. Sometimes it starts cloudy and clears up with time or gentle swirling.

Peptides wouldn't become more stable with time or gentle swirling, as would be the case if cloudiness indicated reduced stability.

Particle formation, ie, aggregation of proteins is a form of peptide instability.

Some aggregation is reversible, which is why agitation or heat may be enough to break apart the peptide aggregates temporarily. By the time you can see it, the aggregates are huge, >100um. Even if they disappear from view, it's very unlikely they separated all the way back to monomers. They're just sub-visible aggregates.