Coming off semaglutide after 2 years

[Dozerpush1437]

I’ve been on semaglutide since October 2023. During this time I’ve lost 197 pounds. 390 down to 193. I just finished a 6 week metabolic break. I’ve been cutting again, at much higher calories, for a week. All is well.

The reason I am posting is because my insurance just changed. The new company won’t cover Wegovy/semaglutide. I have 2 1.7mg doses left before I’m out. I plan to spread them over a month. Hopefully that makes stopping little less abrupt.

I have considered UGL reta at 2-4mg a week when I run out to see if the triple action helps me during this cut. I have also considered stopping GLP-1’s altogether. That prospect is terrifying even with my diet on point.

Does anyone have any advice for coming off GLP-1’s after long term use? This weight loss has completely changed me as man, father, husband. I feel like I’ve done the work with my habits to stop the semaglutide, but it’s still scary. Thanks in advance for your help!

 

[Jesintn]

Congratulations on your fatloss

Yeah my insurance changed in 2020 and wouldn't cover testosterone after 1. 5 years , five tests on low t, and endo putting me on it in 2014 even though I have legit low t

I tried to get script tirz last year and pcp laughed me out of the room saying I don't need it even if my bmi qualifies and had had insulin issues previously

General insurance is nothing like it was 10-20 years ago, it seems

Now insurance changed again , dropped me , and wanting 120$ more a month. And not sure about premium s , they said they'll pay 100$ doctor visits and not sure how much blood labs costs since insurance always payed them fully

Im lean to the right side and love the idea of capitalism , and it seems under Trump insurance costs went up, well they did in fact for me

I s that why he wants to make drug prices 1/10 th of what they were ? Saying usa pays 10 x s plus more than other countries

I may have to pay out of pocket from lab results now , not sure exactly how new insurance works I just know 129$ extra a month for insurance currently and not happy about that

Kind of makes me not want to do labs bc of $ but I know it's best to

I would taper down like any drug it's best to or certain drugs, supplements, it's best

 

[MadaFacor]

Similar story. My advice ...honestly.... Give your receptors a break. Titrate down over a month. See how you deal with it. My guess is you're going to do much better than you think you will because you developed healthy habits at this point and the lifestyle. If you find you start to gain then just reach out to the community and we'll help you with resources. If you're struggling to find a reasonable resource, you can DM me directly. I will help you.

Source: the guy who 290 at 5'7' in 2022. I hovered around 195 to 205 for the last year or so with a body fat between 13 to 14%. I've taken a few breaks and yes I start to trend up.. but nothing that's not easily correctable with lifestyle and a month or two of serious training. Don't be scared... You've already done the heavy lifting.

 

[King_Cnut]

I would honestly listen to @Ghoul about this and stay on a GLP permanently. They are not drugs, they are hormones, like insulin, that you are taking to correct a deficiency. You wouldn't say "I'm cured" and come off insulin once you got diabetes under control

There is also an argument that by stopping and starting GLPs, your body loses sensitivity each time (I can't remember the fancy name for it), and they could end up not working any more over time

If you're at the weight you want to maintain, stay on your current dose (or reta equivalent), which is now your body's homeostatic weight set point. If you want to cut more, increase your dose slightly until you plateau again

 

[songsofpyramids]

Just go get it compounded or buy ugl. I wouldn’t drop the hormone that’s drastically improving your health and lifespan.

 

[BigDadd7]

Ugl is the way to go

 

[touringsedan]

UGL for sure, not to mention Sema UGL is dirt cheap.

 

[Dozerpush1437]

Thanks for the replies, everyone. I really don’t want to get off yet. Am I wrong for wanting to make the switch to reta? I am sitting at 193. I would like to get down to 175-180 and reassess. If I like where I’m at I’ll probably add some gear. I want to be as lean as possible before I start that.

My reasoning for switching to reta is the triple action. I would still get some appetite suppression, but I think the other pathways would help with this cut. Especially cutting on higher calories. I don’t want to go as low as I did while I was losing before. That was miserable. I’m at 2225 calories on my low carb days, 2330 on medium carb days. Training performance is significantly improved. Body composition is improved. When I cut before I was around 1600 calories. I felt like shit.

 

[BigDadd7]

Reta or tiz. Either one is superior to sema.

 

[Cyp180]

I would go for ugl Tirzepatide. Lot of vendors sell 10 vial kits

 

[King_Cnut]

Thanks for the replies, everyone. I really don’t want to get off yet. Am I wrong for wanting to make the switch to reta? I am sitting at 193. I would like to get down to 175-180 and reassess. If I like where I’m at I’ll probably add some gear. I want to be as lean as possible before I start that.

My reasoning for switching to reta is the triple action. I would still get some appetite suppression, but I think the other pathways would help with this cut. Especially cutting on higher calories. I don’t want to go as low as I did while I was losing before. That was miserable. I’m at 2225 calories on my low carb days, 2330 on medium carb days. Training performance is significantly improved. Body composition is improved. When I cut before I was around 1600 calories. I felt like shit.

You still are nowhere near a maximum dose for semaglutide. If you're tolerating it well, you might as well stay on it rather than switching. If it ain't broke, don't fix it.

Yes, you might lose weight a little faster on reta, but it will come at the cost of weaker appetite suppression. A lot of guys here are on reta specifically so they can still eat normally on a bulk, but get the GLP health benefits

If you must switch, tirzepatide is better for your use case than reta. You will still lose weight slightly faster than semaglutide while retaining good appetite suppression

Either way, as others have said UGL is the way to go here