AndorGel is everyday and the hcg is every 3rd. day.
Here is a cut & paste that SWALE should make into a stickey.
Phil
AN UPDATE TO THE CRISLER HCG PROTOCOL
By John Crisler, DO
In my paper "My Current Best Thoughts on How to Administer TRT for Men", pu=
blished in
A4M's 2004/5 Anti-Aging Clinical Protocols, I introduced a new protocol whe=
re small
doses of Human Chorionic Gonadotrophin (HCG) are regularly added to traditi=
onal TRT
(either weekly IM testosterone cypionate or daily cream/gel). The reasons a=
nd benefits of
this protocol are as follows, along with a new improvement I wish to share:=
Any physician who administers TRT will, within the first few months of doin=
g so, field
complaints from their patients because they are now experiencing troubling =
testicular
atrophy. Irrespective of the numerous and abundant benefits of TRT, men nev=
er enjoy
seeing their genitals shrinking! Testicular atrophy occurs because the depr=
essed LH level,
secondary to the HPTA suppression TRT induces, no longer supports them. It =
is well
known that HCGa Luteinizing Hormone (LH) analogwill effectively, and dram=
atically,
restore the testicles to previous form and function. It accomplishes this d=
ue to shared
moiety between the alpha subunits of both hormones.
So, that satisfies an aesthetic consideration which should not be ignored. =
Now let's delve
into the pharmacodynamics of the TRT medications. For those employing injec=
table
testosterone cypionate, the cypionate ester provides a 5-8 day half-life, d=
epending upon
the specific metabolism, activity level, and overall health of the patient.=
It is now well-
established that appropriate TRT using IM injections must be dosed at weekl=
y intervals, in
order to avoid seating the patient on a hormonal, and emotional, roller coa=
ster. Adding in
some HCG toward the end of the weekly "cycle" compensates for the drop in s=
erum
androgen levels by the half-life of the cypionate ester. Certainly the body=
thrives on
regularity, and supplementing the TRT with endogenous testosterone producti=
on at just
the right timewithout inappropriately raising androgen OR estrogen (more o=
n that later)
approximates the excellent performance stability of transdermal testostero=
ne delivery
systems for those who, for whatever reason or reasons, prefer test cyp.
But there's another metabolic reason to employ this protocol. The P450 Side=
Chain
Cleavage enzyme, which converts CHOL into pregnenolone at the initiation of=
all three
metabolic pathways CHOL serves as precursor (the sex hormones, glucocortico=
ids and
mineralcorticoids), is actively stimulated, or depressed, by LH concentrati=
ons. It is
intuitively consistent that during conditions of lowered testosterone level=
s, commensurate
increases in LH production would serve to stimulate this conversion from CH=
OL into these
pathways, thereby feeding more raw material for increased hormone productio=
n. And vice
versa. Thus the addition of HCG (which also stimulates the P450scc enzyme) =
helps restore
a more natural balance of the hormones within this pathway in patients who =
are entirely,
or even partially, HPTA-suppressed.
It is important that no more than 500IU of HCG be administered on any given=
day. There is
only just so much stimulation possible, and exceeding that not only is wast=
eful, doing so
has important negative consequences. Higher doses overly stimulate testicul=
ar aromatase,
which inappropriately raises estrogen levels, and brings on the detrimental=
effects of
same. It also causes Leydig cell desentization to LH, and we are therefore =
inducing primary
hypogonadism while perhaps treating secondary hypogonadism. 250IU QD is an =
effective,
and safe, dose. After all, we are merely replacing that which is lost to in=
hibition.
In my previous report I recommended 250IU of HCG twice per week for all TRT=
patients,
taken the day of, along with the day before, the weekly test cyp injection.=
After looking at
countless lab printouts, listening to subjective reports from patients, and=
learning more
about HCG, I am now shifting that regimen forward one day. In other words, =
my test cyp
TRT patients now take their HCG at 250IU two days before, as well as the da=
y immediately
previous to, their IM shot. All administer their HCG subcutaneously, and do=
sage may be
adjusted as necessary (I have yet to see more than 350IU per dose required)=
.
I made this change after realizing that the previous HCG protocol was boost=
ing serum
testosterone levels too much, as the test cyp serum concentrations rise, ap=
proaching its
peak at roughly the 72 hour mark. The original goal of supporting serum and=
rogen levels
with HCG had overshot its mark.
Those TRT patients who prefer a transdermal testosterone, or even testoster=
one pellets
(although I am not in favor of same), take their HCG every third day. They =
needn't concern
themselves with diminishing serum androgen levels from their testosterone d=
elivery
system. These patients will, of course, notice an increase in serum androge=
n levels above
baseline.
While HCG, as sole TRT, is still considered treatment of choice for hypogon=
adotrophic
hypogonadism by many , my experience is that it just does not bring the sam=
e subjective
benefits as pure testosterone delivery systems doeven when similar serum a=
ndrogen
levels are produced from comparable baseline values. However, supplementing=
the more
"traditional" TRT of transdermal, or injected, testosterone with HCG stabil=
izes serum
levels, prevents testicular atrophy, helps rebalance _expression of other ho=
rmones, and
brings reports of greatly increased sense of well-being and libido. My pati=
ents absolutely
love it. As time goes on, we are coming to appreciate HCG as a much more po=
werful--and
wonderful--hormone than previously given credit.
Copyright John Crisler, DO 2004. This article may, in its entirety or in pa=
rt, be reprinted
and republished without permission, provided that credit is given to its au=
thor, with
copyright notice and
www.AllThingsMale.com clearly displayed as source. Wri=
tten
permission from Dr. Crisler is required for all other uses.
_________________
www.AllThingsMale.com
ANY ADVICE I MAY GIVE IN NO WAY SUBSTITUTES FOR A PROPER EVALUATION BY YOUR=
PHYSICIAN; NOR DOES IT CONSTITUTE DR/PT RELATIONSHIP, OR LIABILITY, IN ANY =
WAY .
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