DHEA and Pregnenolone

[ICBM TANK]

I've been on TRT for about a year and haven't used HCG. Trying out 25mg DHEA and 10mg Pregnenolone after research. Tried the Preg with my last meal around 7pm a few nights ago and noticed a calming effect, clear headedness, and hydrated skin, no more eye irritation/pain (where glasses when studying on the laptop for very long hours).

Took the DHEA after breakfast a few days later, it felt like a stimulus and I felt very goal oriented.

Overall mental aspects is night and day difference. What are your experiences using these compounds? Do you cycle off? I know DHEA can be measured in the blood work but not sure about pregnenolone. What are your doses?

 

[Ryu82]

25mg and 10mg here as well when I am cruising or down to full TRT levels. Huge difference.

I dont use them when blasting though.

 

[ICBM TANK]

25mg and 10mg here as well when I am cruising or down to full TRT levels. Huge difference.

I dont use them when blasting though.

Why don't you use it during a blast? Isn't that the best time to use them, when your more suppressed? This is assuming your still producing a little bit of DHEA and pregnenolone and will stop producing it when your on a blast due to more shutdown.

 

[DeadFlex]

VigorousSteve recommends DHEA and Preg on a blast to maintain neurosteroid levels. I use it in the form of topical administration with Dermacrine.

 

[Ryu82]

Why don't you use it during a blast? Isn't that the best time to use them, when your more suppressed? This is assuming your still producing a little bit of DHEA and pregnenolone and will stop producing it when your on a blast due to more shutdown.

I used too, but I found it actually ended up feeling better without it on blast. Cruise I feel great with it. Just how it works for me I guess.

 

[Rido]

Either hcg or supplement the neurosteroids.

 

[Type-IIx]

Risk-reward profile for progesterone/allopregnanolone supplementation

 

[Dead]

Dhea is insane for cognitive benefit

 

[TRENdy07]

Do you guys take these before bed or in the morning?

 

[thestruggle]

I've been on TRT for about a year and haven't used HCG. Trying out 25mg DHEA and 10mg Pregnenolone after research. Tried the Preg with my last meal around 7pm a few nights ago and noticed a calming effect, clear headedness, and hydrated skin, no more eye irritation/pain (where glasses when studying on the laptop for very long hours).

Took the DHEA after breakfast a few days later, it felt like a stimulus and I felt very goal oriented.

Overall mental aspects is night and day difference. What are your experiences using these compounds? Do you cycle off? I know DHEA can be measured in the blood work but not sure about pregnenolone. What are your doses?

Thanks for sharing. I'm gonna give pregnenolone a trial. What would be the dosage and timing recommendation? Do you take a micronized form?

Here is my experience with DHEA, which is aimilar to yours:

Thread '"Holistic" TRT protocol: DHEA and Pregnenolone?'

Oct 17, 2025

I noticed that since I started TRT, my DHEA-S levels has significantly declined over time.

I find that adding 25mg of oral micronized DHEA to my TRT (50mg TE e4d + 40mg testogel daily + 0.125mg anastrazole e4d) has a clearly tangible effect on my mood, energy and social capacity.

Have you experienced this with DHEA as well? What are the other aspects one should consider to supplement for while on TRT? My stupid endoc doc had no odea about dhea and didn't even check for it.

• thestruggle
• Replies: 36
• Forum: Steroid Forum

 

[thestruggle]

I've been on TRT for about a year and haven't used HCG. Trying out 25mg DHEA and 10mg Pregnenolone after research. Tried the Preg with my last meal around 7pm a few nights ago and noticed a calming effect, clear headedness, and hydrated skin, no more eye irritation/pain (where glasses when studying on the laptop for very long hours).

Took the DHEA after breakfast a few days later, it felt like a stimulus and I felt very goal oriented.

Overall mental aspects is night and day difference. What are your experiences using these compounds? Do you cycle off? I know DHEA can be measured in the blood work but not sure about pregnenolone. What are your doses?

I know pregnenolone can be measured in the blood serum as well, but I was told ny my doctor that the blood serum levels are wildly fluctuating and are not worth checking.

 

[xrayphoton13]

My personal experience is if you really wanna use them do bloodwork first and after.
I decided to try pregnenolone on a whim. Think I only took 50mg, can't quite remember. It was the single only time in my entire life i have ever had trouble maintaining an erection. So clearly I'm not deficient and didn't need it. Stupid idea

 

[thestruggle]

Starting 25mg micronized pregnenolone today, will report back on the outcomes.

Post in thread '"Holistic" TRT protocol: DHEA and Pregnenolone?'

Nov 1, 2025

Starting today, I’m adding micronized pregnenolone (25 mg) in the morning alongside my 12.5 mg micronized DHEA to see if I can restore some of the upstream hormone and neurosteroid activity that TRT alone can’t replace.

DHEA had clear boosts to my cognitive clarity, mood, but my sleep quality is still suffering.

I'm hoping replenishing precursors like pregnenolone and its metabolites (progesterone, allopregnanolone), could may be contribute to GABA balance and overall neuroendocrine function.

I’ll report back on my response over the next few weeks in terms of energy, focus...

• thestruggle

• 

 

[dvalukis]

2cents: I was doing 50mg dhea and 100mg pregnenalone eod after I stopped HCG. It helped for a couple weeks then started making me feel anxious. I felt better after I stopped. Is 100mg of pregnenalone like a crazy-high dose or something?

 

[thestruggle]

2cents: I was doing 50mg dhea and 100mg pregnenalone eod after I stopped HCG. It helped for a couple weeks then started making me feel anxious. I felt better after I stopped. Is 100mg of pregnenalone like a crazy-high dose or something?

I think considering the individual metabolism, 100mg can be too much especially after progesteone levels rise in few weeks time.

50mg dhea, non-micronized, was too much for me; affecting my sleep negatively, but 25mg seems to be the sweet spot.

Started experimenting with 25mg micronized pregnenolone just recently. Will report back.

 

[Conan701]

I've been on TRT for about a year and haven't used HCG. Trying out 25mg DHEA and 10mg Pregnenolone after research. Tried the Preg with my last meal around 7pm a few nights ago and noticed a calming effect, clear headedness, and hydrated skin, no more eye irritation/pain (where glasses when studying on the laptop for very long hours).

Took the DHEA after breakfast a few days later, it felt like a stimulus and I felt very goal oriented.

Overall mental aspects is night and day difference. What are your experiences using these compounds? Do you cycle off? I know DHEA can be measured in the blood work but not sure about pregnenolone. What are your doses?

25 dhea and 10mg pregnenolone daily is what I take also