Did RU58841 stop hair loss against Tren for those prone to hair loss?

[prher]

The whole list is bs. Like what slop am I even reading? Test P is all good buy the moment you touch test enanthate your in the gutter. LOL

It knows nothing.

Binding affinity is also not all that matters at all. RU itself yes has a short half life, but RU is broken into 2 metabolites which have a half life of about 20 hours + you can reapply twice morning and night to have full blockade 24/7.

Stop quoting chatgpt slop. I appreciate a
the attempt at a reply but would rather none at all if it comes straight from chatgpt who is wrong 99% of the time.

Here's a chart ChatGPT generated, you can see tren at the bottom

Steroid	AR Binding Affinity	Ester / Half-life	RU58841 Effectiveness	Notes
Testosterone base	Moderate	Short	High	Rapid dissociation → frequent AR “windows” for RU58841
Testosterone propionate	Moderate	Short (~1 day)	High	Short ester → fairly easy for RU58841 to compete
Dihydrotestosterone (DHT)	High	Very short	⚖ Moderate	Strong binder but short half-life → RU58841 works if applied consistently
Nandrolone (base or propionate)	Moderate	Short/medium	Moderate	Lower AR affinity than tren → RU58841 can compete
Boldenone (base or acetate)	Moderate	Short/medium	Moderate	Similar to nandrolone, fewer “locked” ARs
Testosterone acetate	Moderate	Short (~1 day)	High	Quick release → AR becomes available often
Testosterone enanthate	Moderate	Long (~7–10 days)	⚠ Low	Long-acting ester → RU58841 cannot consistently block AR
Nandrolone decanoate	Moderate	Long (~7–10 days)	⚠ Low	Long ester, slow hydrolysis → few AR windows
Trenbolone base	Very high	Short	⚠ Low	Strong binder, slow dissociation → RU58841 struggles
Trenbolone acetate	Very high	Short (~2–3 days)	Very low	Strong + slow dissociation + moderate ester → hard to block
Trenbolone enanthate	Very high	Long (~7–10 days)	Very low	Most difficult to block; AR effectively “locked” for days

ChatGPT is using the known pharmacokinetics of tren and ru58841 to deduce its effectiveness,

OP posted: "I would have a hard time believe in that it doesn’t though if you use a high enough concentration of RU to saturate the AR"

Tren has 10-15x more binding affinity to the AR than ru58841, Tren stays bound to the AR a magnitude longer than ru58841. ru58841 is cleared faster from the body than tren. Tren's chemical properties make it the single handed the worst steroid to try to block with a AR antagonist

Erased a chunk to try and not take up a whole page.

There are no significant human studies on tren. So there’s no studies on tren and hair loss. ChatGPT is at best looking through anecdotal evidence which is what this forum exists for.

Anecdotally I’ve read plenty of user experiences that ru maintained hair while on tren cycle. Was my experience as well. And these anecdotes are all we have to go on.

A ChatGPT chart does not bring value to the conversation. Op can just ask ChatGPT himself. And I thought chat was no longer going to use forums as sources? If that’s true then I have no idea where it would get data on a subject like this.

 

[thejumpingsheep]

title

appreciate any anecdotes

I am prone to hair loss and Tren-E at 50mg/wk to 160mg/wk did nothing. I take tren on my cruise as well so basically non stop for about 5 months and no hair shedding.

OTOH 20-30mg of Anavar causes all hell breaks loose and hair sheds everywhere a week later... Thats with Finasteride and Minox but never tried it with RU.

 

[prher]

I am prone to hair loss and Tren-E at 50mg/wk to 160mg/wk did nothing. I take tren on my cruise as well so basically non stop for about 5 months and no hair shedding.

OTOH 20-30mg of Anavar causes all hell breaks loose and hair sheds everywhere a week later... Thats with Finasteride and Minox but never tried it with RU.

thanks for input.

160 highest you’ve been?

you’ll likely be fine with var and ru if it was fine against 160 tren. finn won’t do anything for var and if u started minox at the same time as var then you could have expected a minox shed. that or you can’t do var without ru are the explanations for the shed.

 

[thejumpingsheep]

thanks for input.

160 highest you’ve been?

you’ll likely be fine with var and ru if it was fine against 160 tren. finn won’t do anything for var and if u started minox at the same time as var then you could have expected a minox shed. that or you can’t do var without ru are the explanations for the shed.

Ive never gone over 160mg/wk Tren-E. Im fairly new to all this so im taking it slow. I am in cruise right now and gearing up for next cycle. Got Repatha, statins, telmisartan, and glp blockers along with AI and other goodies ready to go. I even got RU but I need to get it tested. Dont trust the source.

I will be pushing Tren a little more next cycle, maybe up to 400mg and I might finally try to blast HGH. Not looking to get huge. Too old for that. But I have one more injury to heal, a partial tear near bicep that has agonized me for 15 years, so I want to optimize muscle growth and focus on it specifically.

I've been on fin/minox a long time. I tried var twice. Once in a Test-C cycle and again in a low test + primo + tren cycle. Each time, shedding like crazy after starting Var. Thats my kryptoniteI guess?

 

[Turkeybuilder]

Howmuch RU are you supposed to be applying daily? Theres so many different variations between mg, % value (ex. 5% solution vs 9%)

 

[ascending0roids]

ChatGPT is using the known pharmacokinetics of tren and ru58841 to deduce its effectiveness,

OP posted: "I would have a hard time believe in that it doesn’t though if you use a high enough concentration of RU to saturate the AR"

Tren has 10-15x more binding affinity to the AR than ru58841, Tren stays bound to the AR a magnitude longer than ru58841. ru58841 is cleared faster from the body than tren. Tren's chemical properties make it the single handed the worst steroid to try to block with a AR antagonist

have u actually tried ru and tren? cuz if you have youd know it protects it, and it does it VERY very good

 

[JG91]

The whole list is bs. Like what slop am I even reading? Test P is all good buy the moment you touch test enanthate your in the gutter. LOL

It knows nothing.

Binding affinity is also not all that matters at all. RU itself yes has a short half life, but RU is broken into 2 metabolites which have a half life of about 20 hours + you can reapply twice morning and night to have full blockade 24/7.

Stop quoting chatgpt slop. I appreciate a
the attempt at a reply but would rather none at all if it comes straight from chatgpt who is wrong 99% of the time.

You shouldn’t appreciate the attempt of a reply. We can all just throw a question into ChatGPT. I’d vote that an answer as lazy as “I took your question and threw it into ChatGPT” should get you a little warning suspension for wasting space on the forum.

Guy clearly doesn’t know shit about tren or RU

 

[Photon]

Howmuch RU are you supposed to be applying daily? Theres so many different variations between mg, % value (ex. 5% solution vs 9%)

If you get RU, don't get the solution.
Get the powder and mix with whatever you're using, mix it with liquid min or something and make small batches.

I believe it loses effectiveness the longer it stays in liquid form. You don't want to buy one made months ago.

 

[Turkeybuilder]

If you get RU, don't get the solution.
Get the powder and mix with whatever you're using, mix it with liquid min or something and make small batches.

I believe it loses effectiveness the longer it stays in liquid form. You don't want to buy one made months ago.

I know there’s so much conflicting info on this topic with no actual research to back any of it up

That’s the real turn off to me leaning towards KX /kintor as opposed to RU because theres no like clear guideline to follow on how to apply it or store it or whats real or made up blah blah lol. Side effects go away and its a short half life so thats not too concerning, but its moreso the not knowing how to properly use it

 

[Photon]

I know there’s so much conflicting info on this topic with no actual research to back any of it up

That’s the real turn off to me leaning towards KX /kintor as opposed to RU because theres no like clear guideline to follow on how to apply it or store it or whats real or made up blah blah lol. Side effects go away and its a short half life so thats not too concerning, but its moreso the not knowing how to properly use it

You could get the powder and add to kx and shake it.
Tho i don't recommend RU, no safety trials.

 

[Cman90]

Tho i don't recommend RU, no safety trials.

I agree with this. I've been looking in to it thoroughly because I'd like to add an anti androgen to my hair loss protocol.

ProStrakan Pharmaceuticals, the original owner of RU, conducted safety and tolerance trials in humans, but never released the actual data and study. They registered it in a database and never followed through with the actual study. This is very alarming.

Take a look at Reta, Eli Lilly is dropping those studies as soon as they are completed because they know there is big $$ in it and the results were favorable.

I think the RU trials found high risk in humans, so they halted the program. If the results were favorable and thought to be profitable, they would have continued development.

ISRCTN

I think there are just as many negative anecdotes of the side effects of RU as positive, or more.

Even MinoxidilMax recommends exercising "a great deal of caution" with RU.

RU58841 For Hair Loss | Safe Finasteride Alternative? A Chemist's View

Some people believe it (or RU-58841, or RU) is a safe alternative to finasteride. But is it really true? Are there any better options available if someone does not want to use finasteride? What is the verdict on how often RU should be used? What are the caveats when one tries to concoct their...

minoxidilmax.com

 

[Photon]

I agree with this. I've been looking in to it thoroughly because I'd like to add an anti androgen to my hair loss protocol.

ProStrakan Pharmaceuticals, the original owner of RU, conducted safety and tolerance trials in humans, but never released the actually data and study. They registered it in a database and never followed through with the actual study. This is very alarming.

Take a look at Reta, Eli Lilly is dropping those studies as soon as they are completed because they know there is big $$ in it and the results were favorable.

I think the RU trials found high risk in humans, so they halted the program. If the results were favorable and thought to be profitable, they would have continued development.

No company will walk away from money.
It's a billion dollar industry.

Instead of RU, i'd recommend Kx826, proven safe in humans.
You can get it direct from the manufacturer on Amazon.
You can buy dut/min/fin raw powders from US sources and mix it in.

and IF you really want to, you can get RU powder and add it in.

 

[prher]

ProStrakan Pharmaceuticals, the original owner of RU, conducted safety and tolerance trials in humans, but never released the actual data and study. They registered it in a database and never followed through with the actual study. This is very alarming.

there were no health risks and safe for humans use

View: https://www.reddit.com/r/tressless/comments/nfig28/i_spoke_to_the_guy_who_did_the_ru58841_psk3841/


View: https://www.reddit.com/r/tressless/comments/176ifd6/safety_of_ru58841_i_talked_to_the_pharma_company/


lack of financing and the state of the market at the time were major factors for why it wasn’t continued. RU was being researched around the same time finasteride was introduced, and finasteride quickly came to dominate the hair loss industry. As a result, the company developing RU likely saw FDA approval as financially unviable, believing they couldn't compete or generate a return on the substantial investment required for clinical trials. This pattern has been common with other potential treatments as well, until more recently. It's easy to see that, for a long time, the mainstream options have remained limited to finasteride, minoxidil, and less commonly Dutasteride.

 

[prher]

I agree with this. I've been looking in to it thoroughly because I'd like to add an anti androgen to my hair loss protocol.

ProStrakan Pharmaceuticals, the original owner of RU, conducted safety and tolerance trials in humans, but never released the actual data and study. They registered it in a database and never followed through with the actual study. This is very alarming.

Take a look at Reta, Eli Lilly is dropping those studies as soon as they are completed because they know there is big $$ in it and the results were favorable.

I think the RU trials found high risk in humans, so they halted the program. If the results were favorable and thought to be profitable, they would have continued development.

ISRCTN

I think there are just as many negative anecdotes of the side effects of RU as positive, or more.

Even MinoxidilMax recommends exercising "a great deal of caution" with RU.

View attachment 367411

RU58841 For Hair Loss | Safe Finasteride Alternative? A Chemist's View

Some people believe it (or RU-58841, or RU) is a safe alternative to finasteride. But is it really true? Are there any better options available if someone does not want to use finasteride? What is the verdict on how often RU should be used? What are the caveats when one tries to concoct their...

minoxidilmax.com

No company will walk away from money.
It's a billion dollar industry.

Instead of RU, i'd recommend Kx826, proven safe in humans.
You can get it direct from the manufacturer on Amazon.
You can buy dut/min/fin raw powders from US sources and mix it in.

there were no health risks and safe for humans use

View: https://www.reddit.com/r/tressless/comments/nfig28/i_spoke_to_the_guy_who_did_the_ru58841_psk3841/


View: https://www.reddit.com/r/tressless/comments/176ifd6/safety_of_ru58841_i_talked_to_the_pharma_company/


lack of financing and the state of the market at the time were major factors for why it wasn’t continued. RU was being researched around the same time finasteride was introduced, and finasteride quickly came to dominate the hair loss industry. As a result, the company developing RU likely saw FDA approval as financially unviable, believing they couldn't compete or generate a return on the substantial investment required for clinical trials. This pattern has been common with other potential treatments as well, until more recently. It's easy to see that, for a long time, the mainstream options have remained limited to finasteride, minoxidil, and less commonly Dutasteride.

“
Topical anti-androgen


This is an innovative molecule with a unique mechanism of action for the treatment of androgen-dependent conditions, such as alopecia and acne.


In pre-clinical studies, it has shown promising activity in various models of acne, alopecia and hirsutism. The product has good systemic and dermal tolerance.


In human clinical pharmacology, there was no systemic anti-androgenic activity and again good general and dermal tolerance.


The molecule has completed several Phase I studies and a Proof of Concept


Phase II study for alopecia.


It has demonstrated similar efficacy after 6 months treatment as that observed with current oral therapy for alopecia after twelve months, based on the increase in net hair count. Again, no systemic anti-androgenic effect was observed (n=90).


く


This product is available for licensing.”

 

[Cman90]

there were no health risks and safe for humans use

View: https://www.reddit.com/r/tressless/comments/nfig28/i_spoke_to_the_guy_who_did_the_ru58841_psk3841/


View: https://www.reddit.com/r/tressless/comments/176ifd6/safety_of_ru58841_i_talked_to_the_pharma_company/


lack of financing and the state of the market at the time were major factors for why it wasn’t continued. RU was being researched around the same time finasteride was introduced, and finasteride quickly came to dominate the hair loss industry. As a result, the company developing RU likely saw FDA approval as financially unviable, believing they couldn't compete or generate a return on the substantial investment required for clinical trials. This pattern has been common with other potential treatments as well, until more recently. It's easy to see that, for a long time, the mainstream options have remained limited to finasteride, minoxidil, and less commonly Dutasteride.

If you're using Reddit and YouTube for guidance on your pharmacokinetic protocols, you're fucked.

The OP for that Reddit post is probably just a shill for MinoxidilMax. There are no published studies to confirm that information.

 

[prher]

If you're using Reddit and YouTube for guidance on your pharmacokinetic protocols, you're fucked.

funny how it wasn’t even originally a reddit post moron

anyway loads have used ru for decades no issue. quit the fearmongering for no reason.

 

[Cman90]

You can buy dut/min/fin raw powders from US sources

Can you point me in the right direction for these? I've been looking for credible sources.

 

[Photon]

Can you point me in the right direction for these? I've been looking for credible sources.

Dutasteride Powder - Carolina Chemical

Buy Dutasteride Powder Online for Oral and Topical Use for Hair Regrowth. Same Day or Next Day Shipping. Low Prices Guaranteed.

carolinachemical.com

 

[Cman90]

funny how it wasn’t even originally a reddit post moron

anyway loads have used ru for decades no issue. quit the fearmongering for no reason.

You're a retard if you think there is no reason to exercise caution with RU. This is a harm reduction forum. Go back to Reddit and TikTok if you're going to encourage people to take potentially harmful substances without educating themselves and taking precautionary measures.

 

[Turkeybuilder]

You could get the powder and add to kx and shake it.
Tho i don't recommend RU, no safety trials.

Yeah then there’s the other part of it where people say you need to store the powder in the freezer or that the reconstituted solution degrades after 2 weeks but then there’s websites like anagenic/minoxidil max that sell the solution form and claim they did their own independant studies and after 6 months there was no degredation

It all seems shady and frustrating. I’m just going to use KX and if there’s no improvement i’ll add RU