DIY T3, Clen or Caber caps/tabs by pouring dissolved in liquid and allow to dry?

[master.on]

Mexican Cynomel had Ethyl alcohol and purified water in it

CYNOMEL, a Mexican version of T3 only, a shortage started in 2016…
Corn Starch
Calcium Sulfate Dehydrate
Sugar glass
Talc
Sterate acid powder
Gelatin
Ethyl alcohol
Purified water
Armour vs. Other Brands (NDT, T3, etc) - Stop The Thyroid Madness

While some of it could be absorbed by other powdery ingredients
it makes sense that most of it was allowed to dry before compressing the tab

I've heard that big-pharma uses robots to evenly spray liquid over evenly spread excipients powder, then set to dry in a special machine.
Who knows with Mexican low wages, maybe they MANUALLY sprayed it.

Manually spraying without filters sounds dangerous
So what about

1 manually pouring liquids slowly and af evenly as possible (maybe with slin syringes) over individual excipient-powder mini puddles (each one weighted for each cap/tab)

2 Allow to dry (I might buy a small explosion-proof extracting fan in Amazon to safely vent alcohol vapors)

3 Grab each dried mini-puddle and pour in caps, or compress to tabs

The only possible downside I can think of
is that some T3/Clen/Caber may settle on the bottom of the recipient on drying
OTOH by having small, INDIVIDUAL recipients (one for each cap/tab) you can't accidentally overdose some tabs/caps

 

[master.on]

In this patent they used Isopropyl alcohol to dissolve Caber
while preventing it from degrading in water
US20020123503.pdf
then they dry it by evaporating the alcohol

 

[Leancuisine]

I don't understand why you would wet a compound just to cap it

 

[master.on]

I don't understand why you would wet a compound just to cap it

You allow the solvent to fully dry before capping it
so the filler absorbs the T3/clen/caber

BTW I'm trying it.
seems to work ok. just mildly mill some powder clumps left after solvent evaporated.
I'll post more details in a couple weeks. so far it works fine. My only problem is capping. I bought too small caps, #5

 

[Leancuisine]

I just don't understand what the whole process accomplishes.
I understand that you let it dry fully before capping, I should have worded my first post better.

What I am wondering is: what is the benefit to doing this as opposed to just capping the powders as is?

That's what I have done with all my oral powders is just weigh and cap. Seems to be working fine.

 

[Leancuisine]

Also, are you working with T3? I've heard it's a rough raw to work with. I am currently using 500mcg T4. Sucks in comparison to T3.

If I ever used T3 I would do it in my garage that is separate from where I and my family stay.

 

[XKawN]

I would assume that by allowing the t3 to absorb into the filler you would have a more consistent and even disbursement of your active ingredient which is very important when working with highly toxic compounds that are measured in mcgs. I've actually been thinking of how i could do this exact thing. I will have to work on this when i have some free time.

 

[master.on]

I just don't understand what the whole process accomplishes.
I understand that you let it dry fully before capping, I should have worded my first post better.

What I am wondering is: what is the benefit to doing this as opposed to just capping the powders as is?

That's what I have done with all my oral powders is just weigh and cap. Seems to be working fine.

The purpose is to try to dose sub-milligram amounts accurately

Try weighing 0.5 mg (typical caber dose per tab) = very hard
Try weighing 25 or 20 MICROgrams (typical t3, clen tab dose) = next to impossible

Also, are you working with T3? I've heard it's a rough raw to work with. I am currently using 500mcg T4. Sucks in comparison to T3.

If I ever used T3 I would do it in my garage that is separate from where I and my family stay.

For T3 you can either mix it in an enclosed vessel (bottle) and swirl it to get dissolved, and wait for airborne powder to settle before opening the bottle
I used a plastic bag completely covering the stir rod and bottle neck, secured with duct tape.
The flexible plastic bag allows to manually move the stirrer somewhat, while keeping it kind of "sealed".

I would assume that by allowing the t3 to absorb into the filler you would have a more consistent and even disbursement of your active ingredient which is very important when working with highly toxic compounds that are measured in mcgs. I've actually been thinking of how i could do this exact thing. I will have to work on this when i have some free time.

1 That's why I used small filler-powder (excipient) puddles, volume roughly measured with a mini spoon just enough for one cap each.

2 Get a lab to allow you to use a pro scale to weigh some milligrams of T3/clen
i.e. you can dilute it
(with ethyl alcohol, methanol, isopropyl alcohol, butanol, THF, etc you may want to avoid water as a solvent as T3/clen/caber degrade on it)
dilute so that every 1/10 of a ml equals your desired PER TAB/CAP dosage, in mcg

3 pour 1/10th of a ml in each filler puddle
a flat surface didn't work well at first
so you may want some small concave containers facing up so that powder remains in puddles and poured liquid doesn't drain to the sides, several rows of table spoons work well, if you somehow hold them facing straight up, i.e. an 1/4 inch wood board may work fine, depending on the spoons you use

4 allow to dry overnight
only open an upper window, so that evaporated solvent gets out but direct air breezes don't get inside the room as to blow the powder away.
an extraction fan can be used if you want

5 some slightly hard clumps may form on evaporation
easy to break down

6 pour each (dried) spoon contents in your capsule funnel or tablet press

7 cap or press

8 enjoy


This ain't a @master.on weird idea
evaporating solvents to leave APIs is a proven pharma technique
Patent WO2008092881A1 - New crystal form of cabergoline
Patent WO2004101510A2 - Polymorphs of cabergoline
Patent US7939665 - Efficient process for the preparation of cabergoline and its intermediates

 

[Holistic]

This is slightly off topic but I was looking at blotter paper. Could u put in glass dish and allow the blotter paper to absorb the t3 then take the total area of the paper and divide the amount of t3 used and cut squares to take, obviously you would want to print squares the size needed on the paper. I've heard of Gummi bears with steroid orals in the gummy bear mix, but the bears were getting moldy so they scrapped the idea.

 

[master.on]

This is slightly off topic but I was looking at blotter paper. Could u put in glass dish and allow the blotter paper to absorb the t3 then take the total area of the paper and divide the amount of t3 used and cut squares to take, obviously you would want to print squares the size needed on the paper. I've heard of Gummi bears with steroid orals in the gummy bear mix, but the bears were getting moldy so they scrapped the idea.

Nice idea but who knows if it'll work:

1 I prefer to use larger solvent amounts rather than drops for accurate dosing. Drops ain't accurate.
i.e. 1/10 to 1/20th of a ml is easy, yet accurate to measure with an insulin syringe
Probably too much solvent for Blotting Paper BP

2 maybe BP retains some solvent?
2.1 It's better to dry out all the solvent for stability. Remember virtually all T3 in liquid form slowly degrades.
2.2 It looks like Methanol it's a better solvent for T3 than Everclear/Ethanol is. It's both more stable and solubility is higher.
Needless to say Methanol is very toxic so you'd want to completely dry it all.
In fact patents advise to use non-hygroscopic (non water absorbing) fillers, for proper drying.

Still, nice idea.
Maybe it'll work with T3/clen in DMSO with just a couple drops?

 

[master.on]

A patent using the same basic idea:
pouring tiny liquid amounts on small powder containers and allow to dry, with provisions for large-scale manufacturing

Patent US8317507 - Systems for making microtablets for drug delivery

Patent mainly aimed at lyophilization
so this method will also work with HCG or GH. Nice