DNP and ATP Synthesis

silkmobility

New Member
Hi all,

I have been getting all information about dnp i can get however i couldn't find the answer to a question i have.

From what i read, 100mg of dnp will equal a ~10% increase in metabolism and reduce atp synthesis by ~10%, right?

"Under these conditions, much of the food that we eat could not be used for ATP synthesis and we lose weight. Simply put, this means that while eating your normal diet, you will have somewhere between 20% and 40% reduction of calories."

So basically what i wanted to ask is if the active blood level of dnp is 1000 mg (which is the cumulative of about 400mg/day dosage) will the ATP synthesis be reduced by 100%?

Will this mean that all calories from carbs will be dissipated as heat instead of getting stored?

If so a diet mainly made by complex and simple carbs and some protein of course to spare muscle would be best as the body wouldn't store a single calorie from carbs.

Could anyone help me out here?
 
Hi all,

I have been getting all information about dnp i can get however i couldn't find the answer to a question i have.

From what i read, 100mg of dnp will equal a ~10% increase in metabolism and reduce atp synthesis by ~10%, right?

"Under these conditions, much of the food that we eat could not be used for ATP synthesis and we lose weight. Simply put, this means that while eating your normal diet, you will have somewhere between 20% and 40% reduction of calories."

So basically what i wanted to ask is if the active blood level of dnp is 1000 mg (which is the cumulative of about 400mg/day dosage) will the ATP synthesis be reduced by 100%?

Will this mean that all calories from carbs will be dissipated as heat instead of getting stored?

If so a diet mainly made by complex and simple carbs and some protein of course to spare muscle would be best as the body wouldn't store a single calorie from carbs.

Could anyone help me out here?

use your search function and look up posts from Concilliator. He is the resident DNP guru.
 
NOT if ATP synthesis is reduced 100% YOU DIE! How else are maintenance energy requirements met, aerobic metabolism substituting TWO ATP for THIRTY SIX.... NOT!
In fact this is exactly what occurred in roughly 200 people reported in the literature (which suggests there are considerably more) who DIED from using DNP.
Why else do you believe the FDA removed this drug from the US market?
:)
 
FYI
DNP uncoupled oxidative phosphorylation associated with the Krebs cycle and all food stuffs are metabolized in this "cycle" not just CARBS!
:)
 
I dont not think it stops or reduces atp synthesis..It rapidly depletes atp stores forcing the body to use bodyfat and some muscle not only for energy but in an effort to replenish the depleted atp stores.
 
Hmm you don't "THINK" DNP, stops or reduces ATP synthesis? Interesting idea and supposition BUT do tell, where exactly is the human ATP battery your describing located (organ, cell)? Perhaps reading about "oxidative phosphorylation" on Wiki would elucidate DNP's mechanism of action and enhance your cumulative understanding of this drug.
:)
 
The 100% reduction in ATP Synthesis i was talking about is carbs related, i assume that simple sugars and most carbs will be thrown of as heat opposed to fat and protein which are still being absorbed at some extent.

Everybody who has used DNP knows that carbs will heat up like hell and fat and protein won't.

From DNP mechanism of action this means that there is much more inefficiency metabolizing carbs.

A 100% atp reduction would obliviously kill you as DNP affects many types of cell and as such some body functions would stop however the body as other ways of producing energy, that's just the main one.

So, theoretically if a 90% - 100% inefficiency in metabolizing carbs is reached, almost all carbs will be dissipated as heat instead of absorbed.

Which means that you can have a carbohydrate rich diet and almost none of the calories coming from carbs will be absorbed, allowing you to increase your protein or fat intake.
 
I will attempt to explain energy production common to all animals. Upon completion I hope you will understand WHY D.N.P. can kill you as it has others whose demise is well documented in the literature. Moreover after 20 years I've been personally involved with TWO DNP deaths with another fella was left brain dead.
Let's gander at your assertions first.
1) You reference the diminutive effect DNP has on ATP as a form of selective metabolism.....as I will show you later, the drug is NOT substrate selective, it prevents ANY foodstuff from being converted into ATP energy
2 You go on to state DNP's effects on carbohydrates are so exacting that the production of ATP/energy may be reduced 100% or to zip. Now if this is indeed the case how are basal metabolic demands achieved? The brain and heart ONLY uses glucose as an energy source excepting fasting where ketones my be utilized. Perhaps the reason glucose is catabolised as an energy source is essentially all cells (with mitochondria) are capable of using it!.....YEP!
3) Just to clarify DNP has no effect on "fat or protein GI absorption"
4) DNP's "mechanism of action" has absolutely nothing to do with the energy source being "carbohydrates" proteins, or fat! It's NOT a SERM (AKA Selective ENERGY Receptor Modulator)
5) You state the human "body has other ways of producing energy" besides ATP, it's "just the main one"...........HORSESHIT....and neither does any other LIVING thing, (that would exclude rocks, lol!)
6) Lastly you state again because DNP is so carbohydrates selective that we could "theoretically" adjust the DNP dosing just right such that carb energy production is reduced between 80-90%. This would enable the consumption of increased amounts of fats and proteins!
ON MY NEXT POST I will display a few diagrams which depict mammalian energy production. The initial step is glycolysis (glucose lysis (cutting)) where glucose is PROGRESSIVELY broken into varied byproducts (CO-2 and H-2-O) in addition to NADH which is processed within the mitochondrial "electron transport" system DOWN an electrical GRADIENT using OXYGEN as the carrier. (Now you know WHY oxygen is so important). Consequently 36 to 38 ATP is produced by metabolizing one GLUCOSE MOLECULE. DNP BLOCKS THE "ELECTRON TRANSPORT" PROCESS (AKA oxidative phosphorylation)and anaerobic metabolism remains as the ONLY energy source for a whopping 2 vs 36 ATP. That is the closest one can be to understanding metabolic suffocation excluding cyanide, lol!
More importantly the primary organ responsible for gluconeogenesis literally meaning; glucose-new-birth is the liver and to some extent the kidneys. Consequently once blood sugar levels begin to fall because DNP is wasting it as heat, the liver begins to manufacture new GLUCOSE out of either fat or protein yea using the Kregs cycle and same dagnabit electron transport system. Therefore DNP is no more selective for glucose than a FAST, with the readily available glycogen stores being used first, thereafter serum glucose becomes diminished and finally fats and proteins are utilized. DNP HAS NO EFFECT ON THE SUBSTRATES (carbs vs fat vs protein) OR THE ORDER OF METABOLISM! (carbs first, no second, fat first.....no proteins last, wait nd).
I will post a few diagrams the concept is important not all the intermediate steps
Look at the diagrams and follow the metabolism of "PYRUVATE" and 'ACETYL COA" up from the "new glucose" pathway AND begin to understand energy may come from all foodstuffs (carbs, protein, fats) !

:drooling::):D
 
Look at the diagrams you'll note that fatty acids are use as energy but so are proteins, The only difference being their point of entry into the Krebs cycle.
The diagrams are much easier to follow if opened simultaneously, but note the FINAL COMMON PATHWAY FOR ALL SUBSTRATES AS ENERGY PRODUCERS IS THE "ELECTRON TRANSPORT SYSTEM"
:)
 

Attachments

  • electron transport.GIF
    electron transport.GIF
    102 KB · Views: 12
  • FATTY ACID.gif
    FATTY ACID.gif
    11.1 KB · Views: 14
  • gluconeogenesis.jpg
    gluconeogenesis.jpg
    77.7 KB · Views: 14
  • aminoacids.jpg
    aminoacids.jpg
    12.7 KB · Views: 14
Thank you for such enlightenment replies.

I have already researched alot about DNP however, chemistry isn't really my thing at least the advanced kind of chemistry, the basics i get.

Taken from arizona biology edu
In oxidative phosphorylation, the flow of electrons from NADH and FADH2 to oxygen results in the pumping of H+ from the matrix to the inner membrane space. This gradient of H+ can produce ATP by flowing through ATP synthetase in the mitochondrial inner membrane. Dinitrophenol disrupts the H+ gradient reducing ATP synthesis. Under these conditions, much of our food that we eat could not be used for ATP synthesis
"If electron transport doesn't produce ATP, then much more sugar must be metabolized for energy needs."


When you say that the final common pathway is blocked by DNP are you saying that almost all calories from food aren't absorbed as the pathway is blocked?

If so why do you need a diet to get the best results when running DNP?
If Dnp blocks the pathway won't all the calories you eat be thrown of as heat?

Just a thought.
Another thing, when fatty acids are broken down they need to enter an energy cycle. Fats are fed into the citric acid cycle as acetate and in order to get the cycle moving they need to bind with oxaloacetate.

The main source of oxaloacetate is pyruvate and this is the end product of the glucose metabolism.

Would this mean that the more oxaloacetate the body has the more fat loss will be achieved?
If so the "more" carbohydrates we eat the better the weight loss will be.

Thank you,
Silkmobility
 
As i was unable to find an definitive answer to my question so i did a little experiment.

I decided to run 600mg ed of actual dnp taking into count the amount of sodium in dnp and try to out eat the dnp fat loss effects in order to determine if it's possible to gain fat while on DNP.

I ate everything that was hyper-caloric, i ate about 3kg or more of food everyday, in which i ate 200g of chocolate, 500g ice cream, 500g cookies, 400g of sugar cereal all this without even counting lunch or dinner in which i ate pizzas, pasta with cheese Mcdonalds, in one day i ate a whole lemon cheesecake as a dessert which at 400 Kcal per 100g would equal 4000 kcal just from the cheesecake which is more than twice my calorie requirements, i'm 70 kg and 1.8meters height so my calorie need are far from 4000 Kcal.
I did this for 8 days. Eating more than 9000 calories a day, it was painful to eat so much, as i never eat so much.

Dnp will bloat you to hell but add a ton of carbs, sodium, etc and you got a bloat almost like you're pregnant, i didn't weight myself during the cycle however i much have reached almost 80kg which is 10 more than i currently have.

After i stopped all this feasting and the water weight was gone, i was exactly at the same weight 70kg, which is somewhat kinda confusing as 600mg should increase the metabolic rate by ~66%, which would mean my basal metabolic rate would be at 2934Kcal, yet i was eating more than 3 times that amount and ~3500Kcal will equal 1 pound of fat, so i should have gained at least 12 pounds of fat and that's an underestimate.

I don't know how some people can eat more than 4000 kcal a day, i was in almost agony every time i was eating something, i had to smoke a ton of weed to get an appetite as i would eat breakfast and feel full for the whole day.

The only benefit i took from this experience is that it will be easier to follow my diet which i actually like because it's "light" i don't feel sluggish after i eat as i don't like that sensation, i got sick of crappy food, now when i see crap food i get kinda nauseated. I felt like i was in a coma state all the time, i felt like the only thing my body was doing was digesting food, i couldn't think and it wasn't from the weed as it actually helped in the thinking as stranger that sounds as i wasn't focusing on the discomfort anymore.

I feel sorry for morbid obese people as food seems more addictive to them than crack, for me food is like alcohol (which i don't like that much but drink on social meetings) two, three drinks and i'm done, i can only drink so much alcohol before it becomes an agony to drink more, all i get is a little tipsy tops.
The same with food, after so much food it becomes an agony to eat more.

My conclusion is that you can't gain fat while on moderate DNP dosage however you can out eat the beneficial effects of DNP, that's why a clean diet is important on DNP no matter what many say that they ate pizzas and burgers and ice cream, at a certain dosage and calorie intake you won't gain fat however you won't loose which if you're taking DNP is what you want.

If you're overeating a effective DNP dosage and not loosing any fat you're crazy and in fact you have a huge diet issue to resolve, get you're diet right before jumping into the DNP wagon.

Well maybe some people could use DNP if it is crystal on they're cheat days however be prepared for a useless day as the sluggish you get from eating to much food plus the lethargy you get from DNP will stop you from doing anything productive.

PS:
Don't try this. Even though some people have and currently do this, it's stupid. Why take something that can be harmful for your body without any benefit?
 
Last edited:
I see you ate all kind of macro nutrients in huge amounts, fat, carbs, protein.
However if those 9000 Kcal came from carbohydrates would the results be the same?

I posted a new thread regarding DNP and diets, as i'm new here i'm waiting for it to be approved, if you and DR.Jim could contribute i would greatly appreciate.
 
Back
Top