DNP Neuropathy

[militarypress]

This has been mentioned before in another thread.

While running DNP a friend of mine developed what they believe to be neuropathy in their feet and ankles. They will of course go and see a medical practitioner first thing in the morning.

Does anyone with any research on neuropathy and DNP know anything about this. Has anyone else experienced it and did it go away? My friend has now ended the cycle of course.

 

[militarypress]

Just incase anyone is interested, I was doing some research as the doc had no clue. I am betting that DNP and free radicals are the cause. One of the causes of peripheral neuropathy is free radicals.

I've not read up on this majorly but the accumulation of this beginning in the outer extremities is a similar symptom of alcoholic neuropathy due to increased oxidative stress and alcohol induced malnutrition (I don't think malnutrition was a factor for me lol). Which unfortunately never goes away.

Promptly started taking large doses of vitamin b12 which can help nerve damage and extra ALA for its antioxidant effects to see if I can reverse this.

I took no antioxidant supplement while on but consumed lots of antioxidant-rich foods. Perhaps not enough. Was a long cycle also.

I'm not damming long cycles for everyone but in terms of my own experience I now think shorter cycles seem more logical due to the build up effect I believe I experienced. Don't ask me to back that up with research lol just my $0.02.

 

[yeaokay]

How long was your cycle and what were the doses?

 

[captshiner]

i experienced this a few years ago when I first used it. I was bed ridden because the pain was so intense...took me 2 months walking on the outsides of my feet because it was so unbearable. I still have sensitivity when walking with bare feet on say concrete.

The neurologist will give an EMG..after that its just time in it getting better. I don't think it has anything to do with free radicals.

The neurologist will give an EMG. The chances of him knowing why DNP

 

[captshiner]

er... meant to say mentioning DNP to the doctor will likely be useless. I have had a lot of people on this board PM me about the same issue, one guy having. such pain he stayed overnight in a hospital.

 

[captshiner]

also, one legit explanation I looked into was hypoxia.

 

[whitegato777]

Ive had sharp needle pains in my back. Felt like nerves

 

[militarypress]

the cycle was 6 weeks crystal. Diet deficit was between 1000kcal and 0 (maintenance calories). I have a very high tolerance it seems. started at 250mg week 1, then 500mg the rest of the time. This is comfortable for me - just a little hotter than usual. Perhaps this was too long. Probably.

I had some more bloods done and my levels of CRP (C reactive protein) were raised which usually means inflammation and can suggest an auto-immune disease (thank god I don't have that). I think this may be due to the DNP perhaps.

well luckily for me the pain isn't too bad just very numb and uncomfortable. Feels like I'm walking on stilts. The numbness is also slightly affecting my fingertips now which is a little distressing.

 

[captshiner]

from another board I frequent:


I had DNP induced peripheral neuropathy in 2001. It took a couple of years to clear up. And let me tell you, it was not fun. it got shooting pain up and down my legs, I had serious issues with my feet as well (Sometimes they were hyper-sensitive to touch, and other times I could barely feel anything)
It was extremely painful just putting on my socks.

If you get nerve pain, you need to do a few things.

#1: Stop the DNP or you will destroy more of your myelin sheath(Keep in mind that the myelin sheath CAN recover if you haven't done a lot of damage)

#2: Take massive amounts of oral Acetyl-L-Carnitine(10g+/day orally)
At the time AlCar was pretty expensive and i was buying it by the kg.(we're talking thousands of $$$) (I even bought an injectable version from animal and injected it straight into my ankle(It was 250mg/ml). It burns like hell. Be warned)

#3: As Proton has suggested load up on Lipoic Acid. I highly recommend you use the r-enanthiomer(r-ALA) instead of the normal ALA. You will get less heartburn and IMHO its far more effective.

The only experimental drug I ever came across for nerves was the recombinant nerve growth factor NGF that was being manufactured by genetech at the time. I made enquiries through my doctor to buy it as it seemed to actually have the potential to work but they had stopped producing it. This may have changed. (I know full well how desperate you get when you can't stop the nerve pain no matter what you do so that might be one avenue open to you)

#4: Gabapentin(Neurontin) does jack shit tbh. Don't even bother as it will just make you sluggish.

#5: Use the pain meds ONLY for sleeping purposes as you will build up a tolerance pretty quickly.

 

[CubbieBlue]

from another board I frequent:


I had DNP induced peripheral neuropathy in 2001. It took a couple of years to clear up. And let me tell you, it was not fun. it got shooting pain up and down my legs, I had serious issues with my feet as well (Sometimes they were hyper-sensitive to touch, and other times I could barely feel anything)
It was extremely painful just putting on my socks.

If you get nerve pain, you need to do a few things.

#1: Stop the DNP or you will destroy more of your myelin sheath(Keep in mind that the myelin sheath CAN recover if you haven't done a lot of damage)

#2: Take massive amounts of oral Acetyl-L-Carnitine(10g+/day orally)
At the time AlCar was pretty expensive and i was buying it by the kg.(we're talking thousands of $$$) (I even bought an injectable version from animal and injected it straight into my ankle(It was 250mg/ml). It burns like hell. Be warned)

#3: As Proton has suggested load up on Lipoic Acid. I highly recommend you use the r-enanthiomer(r-ALA) instead of the normal ALA. You will get less heartburn and IMHO its far more effective.

The only experimental drug I ever came across for nerves was the recombinant nerve growth factor NGF that was being manufactured by genetech at the time. I made enquiries through my doctor to buy it as it seemed to actually have the potential to work but they had stopped producing it. This may have changed. (I know full well how desperate you get when you can't stop the nerve pain no matter what you do so that might be one avenue open to you)

#4: Gabapentin(Neurontin) does jack shit tbh. Don't even bother as it will just make you sluggish.

#5: Use the pain meds ONLY for sleeping purposes as you will build up a tolerance pretty quickly.

It boggles my mind how dangerous this substance is and the amount of people that use it seemingly every summer....use some common sense guys!

 

[stucko88]

I posted a similiar thread in february. Mine was alot worse. I think it was probably due to the cold water I used to leave my feet in hours at a time to relieve some of the pain. Also using some Chinese herbal rub made it 10 times worse. Literally minutes after applying the rub my feet were on fire and I couldn't walk (this lasted a month). I spent 2 weeks of hell in the hospital.

It's now 7 months later and they're still not normal. For the first 2 months Percocet was a life saver. I originally started on high doses of Gabapentin, but now I'm on a low dose before bed. Also like you mentioned use high doses of B12. After I take it the pain literally disappears anytime I have discomfort.

Believe me I wish I never did it. I don't think anyone wants to admit it, but DNP can get addictive, especially when your shedding 1-2 pounds a day weeks at a time. I haven't done cardio sijnce or worked out legs properly. I really miss squating. Peripheral neuropathy can also cauise muscle atrophy so I would stilll try to do some basic leg workouts. My legs looked malnourished by the time I got back into the gym. Good luck and keep us updated on your progress.

 

[militarypress]

thanks for all your input. This is the only board I've been on that has given me any info on it. When I researched DNP I did not know about this risk and now I'm suffering from my own ignorance. If I had stopped when it only affected my big toe, it wouldn't be so bad. I think the neuropathy thing should be put in a sticky somewhere to tell people to stop as soon as it manifests itself. I've stopped going through loads of ibuprofen now and I've switched to smoking weed.

I did some research and cannabis is used to help with the symptoms of alcohol induced, diabetes induced and other forms of peripheral neuropathy. It seems to take the stabbing pains and tingling away, still numb though.

My hands have stopped tingling now which is a good sign. B12 1000ui/day, Acetyl-L-Carnitine 20g/day, sound ok?

 

[ColeWorld88]

Sorry to bump this thread but how long did it take for you guys with DNP induced neuropathy to recover. I just got it and I'm off to the doc on friday to get it seen to.