Does high E2 cause inhibition of androgen receptors?

[smartgear]

Yes, I know E2 is anabolic and it's the low E2 that causes the issues in terms of muscle growth, but the penis tissue is different compared to muscle tissue, so I don't know.

I heard that elevated E2 can reduce the sensitivity and the number of androgen receptors in the penis, causing erectile issues.

I don't have testosterone-estrogen imbalance because the testosterone level is significantly higher than E2.

My blood work 12 hours after injecting testosterone:

Total testosterone: ~5,000 ng/dL
Free testosterone: 1 to 1.3 times above reference range
DHT: This is at upper end of reference range without exceeding it
E2 (estradiol): ~500 pmol/L

At this e2 level, I'm not experiencing any side effects, including water retention, gynecomastia and erectile dysfunction.

I have been on these levels for around 1 year.

In the long-run, can such values cause any erectile issues and issues related to androgen receptors' sensitivity and number in muscle tissue and in the penis?

I basically heard that elevated E2 can reduce the sensitivity and the number of androgen receptors, even if androgen levels are high and are trying to cause upregulation of androgen receptors.

Is this true or it's just broscience?

 

[ErectionAdvisor]

Are you on tren? If so get sensitive e2 and retest

If not, most definitely take an ai.

 

[smartgear]

Are you on tren? If so get sensitive e2 and retest

If not, most definitely take an ai.

No, I'm on testosterone only.

Why using AIs if I don't have any e2 side effects?

 

[ErectionAdvisor]

No, I'm on testosterone only.

Why using AIs if I don't have any e2 side effects?

Because there are still other health risk of that level high estrogen exposure beyond just the side effects you’re thinking of

 

[Chips7]

Dude when you have a question like that about androgen receptor in penile tissue.

And a guy who's username is Erectionadvisor are trying to come and help you, i will listen.

 

[UncleBuns]

E2 is not anabolic. E2 does serve important functions for health and well-being in men though. E2 outside of healthy range is never good no matter what your testosterone level is. Having chronically high E2 is not healthy and will have negative consequences. Having high E2 high is not anabolic and will not help with anabolism.

Take AI to keep E2 within healthy range at all times. Whether you are on blast or trt.