E2 control with Primo on TRT

[goulash_ragu]

Hello,

Did labs recently while on 140mg/week TRT protocol and my e2 came a bit high. I’m thinking about using ~70mg/week of Primo to control it, and then do another lab test around 3 weeks after starting Primo (according to steroidplotter it should be enough to saturate my system with it) to adjust if necessary.

Anyone else is doing it? How’s your experience and what ratio are you using?

I have Aromasin and about to receive Arimidex too, but would like to not use them. Maybe it’s foolish and lowering e2 is lowering e2, regardless of the route.

Lastly, my reasoning for going this route is due to primo helping with joints/tendons (I’m doing a combat sport), so anything extra is a plus. I don’t care about my hair.

Thank you!

 

[T&H]

Hello,

Did labs recently while on 140mg/week TRT protocol and my e2 came a bit high. I’m thinking about using ~70mg/week of Primo to control it, and then do another lab test around 3 weeks after starting Primo (according to steroidplotter it should be enough to saturate my system with it) to adjust if necessary.

Anyone else is doing it? How’s your experience and what ratio are you using?

I have Aromasin and about to receive Arimidex too, but would like to not use them. Maybe it’s foolish and lowering e2 is lowering e2, regardless of the route.

Lastly, my reasoning for going this route is due to primo helping with joints/tendons (I’m doing a combat sport), so anything extra is a plus. I don’t care about my hair.

Thank you!

I'm getting bloodwork tomorrow running test and primo. If this thread is still going, I'll post results.

In past with bloods and test around 1400ng and primo at 500mg, E2 was 21 with no AI. So I believe for me, it does reduce it.

 

[Fenrir51]

I ran Test C @ 175mg/wk and 200mg/wk primo, total test was 1264ng/dl, 41.3 pg/ml free test, and 32pg/ml E2. So from my experience it does work.

 

[goulash_ragu]

I'm getting bloodwork tomorrow running test and primo. If this thread is still going, I'll post results.

In past with bloods and test around 1400ng and primo at 500mg, E2 was 21 with no AI. So I believe for me, it does reduce it.

Thanks man, appreciate it! So I take it your current test/primo ratio is around 2:1?

 

[T&H]

Thanks man, appreciate it! So I take it your current test/primo ratio is around 2:1?

400 test, about 500 primo.

 

[boophomet]

I run primo with my TRT, though primo is really effective for me. Some people can get away with 1:1 ratio, but I use about 70 mg/week primo with 175 mg/week test. I found its better to start lower and work your way up because if you're using primo enanthate, it's better to spend 3 weeks with high e2 than 3 with low e2

 

[goulash_ragu]

I run primo with my TRT, though primo is really effective for me. Some people can get away with 1:1 ratio, but I use about 70 mg/week primo with 175 mg/week test. I found its better to start lower and work your way up because if you're using primo enanthate, it's better to spend 3 weeks with high e2 than 3 with low e2

Great and actionable feedback, thanks! Do you feel e2 lowering effects immediately or does it take a little while to kick in? I thought it’d take about 3 weeks due to saturation.

 

[crtx]

Primo TRT

 

[goulash_ragu]

Primo TRT

Is there a problem with that?

 

[strongsafety41]

Is there a problem with that?

Just keep eye on your blood markers/lipids. For some ppl even at low doses primo can affect LDL. As you know it’s effective at lowering E2 which in turn impacts lipids.
I’m waiting on labs now as I’ve modified primo that I’m running with TRT. Currently running 160 test 160 primo.
I was running 160 test 200 primo, felt great but ldl was elevated. I didn’t check my e2 then, but ordered it along with lipids this go around.
Everyone is different, just have to find what works for you.

 

[goulash_ragu]

Just keep eye on your blood markers/lipids. For some ppl even at low doses primo can affect LDL. As you know it’s effective at lowering E2 which in turn impacts lipids.
I’m waiting on labs now as I’ve modified primo that I’m running with TRT. Currently running 160 test 160 primo.
I was running 160 test 200 primo, felt great but ldl was elevated. I didn’t check my e2 then, but ordered it along with lipids this go around.
Everyone is different, just have to find what works for you.

Thanks for the tip! Yeah I plan to do test/e2/Cmp/lipids about 3 weeks after starting primo. I also just got some citrus bergamot, which supposedly helps with lipids, so hopefully that will aid as well. I want to do only 70mg of primo for 140mg of test, but thanks for your caution I didn’t know primo affected lipids

 

[strongsafety41]

Thanks for the tip! Yeah I plan to do test/e2/Cmp/lipids about 3 weeks after starting primo. I also just got some citrus bergamot, which supposedly helps with lipids, so hopefully that will aid as well. I want to do only 70mg of primo for 140mg of test, but thanks for your caution I didn’t know primo affected lipids

70mg of primo per week shouldn’t have too much of an an impact of your lipids. It’s just best to check and make sure, especially if you’re already getting labs anyway. I know guys that run 200mg of primo pw without issue. I’m just not that lucky.

 

[1Megaman]

200 test 150 primo kept my e2 at 22 if I remember right. No change in lipids for me on that combo.

 

[FlawFloor]

200 test 150 primo kept my e2 at 22 if I remember right. No change in lipids for me on that combo.

Similar to results i had at those doses

 

[Jin23]

Is there a problem with that?

Ofc there is a problem with that. You are adding an anabolic steroid to your trt. If you want to lower e2 first check your bloods, how high is your testosterone. You shouldn't have 71 e2 with normal testosterone levels. And further on, you should use an Ai to lower estrogen. There is nothing wrong with that. There is a lot wrong with adding an anabolic to the regime though. But you're on the wrong forum for this discussion. If you want confirmation bias, then yes, this is the place.

 

[goulash_ragu]

Ofc there is a problem with that. You are adding an anabolic steroid to your trt. If you want to lower e2 first check your bloods, how high is your testosterone. You shouldn't have 71 e2 with normal testosterone levels. And further on, you should use an Ai to lower estrogen. There is nothing wrong with that. There is a lot wrong with adding an anabolic to the regime though. But you're on the wrong forum for this discussion. If you want confirmation bias, then yes, this is the place.

Let me quickly confirm, are you a medical doctor? You’re pretty convinced of your ways, especially how a person you’ve never talked to should handle their TRT. So I just want to confirm that you have appropriate credentials before we continue this conversation. Appreciate the input though.

 

[Jin23]

Let me quickly confirm, are you a medical doctor? You’re pretty convinced of your ways, especially how a person you’ve never talked to should handle their TRT. So I just want to confirm that you have appropriate credentials before we continue this conversation. Appreciate the input though.

What?

I'm not completely sure I understand your tone; are you being snarky, dismissive or are you genuine?

And I've got a question for you, beside the ones I've already asked (your bloods, which you haven't posted): with me offering the first negative opinion towards the use of excess androgens on a medical hormone replacement protocol, why am I the first person that you're being seemengly critical towards? You've had plenty of affirmative answers but have not asked a single person about their credentials?

 

[goulash_ragu]

What?

I'm not completely sure I understand your tone; are you being snarky, dismissive or are you genuine?

And I've got a question for you, beside the ones I've already asked (your bloods, which you haven't posted): with me offering the first negative opinion towards the use of excess androgens on a medical hormone replacement protocol, why am I the first person that you're being seemengly critical towards? You've had plenty of affirmative answers but have not asked a single person about their credentials?

Because I asked them about their experience with primo and how it affected their e2? They provided their experience.

If you have first hand experience with using primo with TRT and it negatively affecting your health markers then please share.

Does the difference make sense?

 

[boophomet]

Great and actionable feedback, thanks! Do you feel e2 lowering effects immediately or does it take a little while to kick in? I thought it’d take about 3 weeks due to saturation.

It takes a while, the low e2 feeling creeps up on you when you least expect it. You could also have some emergency dbol on hand in case you get too low, a quick 15mg of dbol will help you get by while you wait for your dosage adjustments to settle

 

[Jin23]

Because I asked them about their experience with primo and how it affected their e2? They provided their experience.

If you have first hand experience with using primo with TRT and it negatively affecting your health markers then please share.

Does the difference make sense?

It does.

To answer your question, I'm not a doc, just a well educated and experienced user.

I'm just going to echo my previous wordings: adding another androgen to trt is not healthy. It's not trt anymore, it's a cruise. Important to make that distinction. However, your e2 readings suggest that your are on cruise already. What does your other blood work say, total test and free test? You should have shared that in the OP and how experienced you are with aas as with your age and other info ...

You should take into account that there is much, much more to it then just the impact on lipids. Primo is a dht derivate anabolic steroid and is impacting everything, from your brain to your liver and kidneys ... Impacting things like neuroinflammation (anxiety and depression), it modulates the glucocorticoid system (impacting water homeostasis and also impacting behaviour), it inhibits certain enzymes, it's going to compete with other androgens systemically in your tissues and organs, consequently having a multitude of outcomes, etc. etc.

It's one thing being on primo for a short while, but it's a completely different thing being on it for years on end. The internet is filled with brosky's advising or advocating the use of extra androgens to modulate your trt, but don't be swayed brother, this are just layman, they don't know what they're talking about. Things are much more complicated then an average seemingly educated gym rat can imagine.

You want health, stick to trt levels, you shouldn't need an Ai. And if you do, use an Ai. We don't have a full picture of how primo lowers e2 anyway. There are a handful of anecdotes connecting primo to low libido (my experience also) with estrogen still in normal range, suggesting it doesn't lower estrogen equally in all tissues and it also might be competing with normal DHT at systemically important sites, changing normal physiological functions of varying systems ... Again, it's complicated.

75mg also wont lower your high estrogen to adequate levels.