First DNP Cycle, looking for feedback

[enigma735]

Hello gents, I'm planning on starting my first DNP cycle on Monday and was just looking for some feedback and answers to some small questions I have.

I am planning to run it for two weeks this run. I will be starting at 1 cap a day (250mg crystalline DNP provided by D himself) for the first 4 days and then will assess based on sides and consider upping to 2 caps a day for the remaining 10 days of the cycle. I won't go beyond that because well, I have no death wish.

As far as support vitamins, I'll be taking anavite as my multi, I also have 500mg vitamin c and 1000iu vitamin e on hand and will probably take them twice a day, but with that and the multi I don't think I should need much more. I will also be running PES Shift, BPI QuadraLean (both non stim and basically for additional support), as well as my standard omegas.I have EC on hand in case the lethargy kicks in.

My question really is around DMAA. I have Jacked Up for preworkout but it has DMAA in it, so I'm wondering if I should forego that and use something like Amino Energy that's just basically bcaa's and caffeine.

Also, I'll be running mostly low carb / ketogenic, but would it be beneficial to throw in a couple of carb up days to replenish glycogen and prevent brain fog?'

Anyone have any feedback or input? Always welcome recommendations.

By the way, I picked up my DNP from the man Dinitro. The guy is great, very responsive, answered some questions I had, and shipped everything really quickly. Also super discreet and professional throughout the process, so I highly recommend him.

 

[Dr__Jan_Itor]

Hello gents, I'm planning on starting my first DNP cycle on Monday and was just looking for some feedback and answers to some small questions I have.

I am planning to run it for two weeks this run. I will be starting at 1 cap a day (250mg crystalline DNP provided by D himself) for the first 4 days and then will assess based on sides and consider upping to 2 caps a day for the remaining 10 days of the cycle. I won't go beyond that because well, I have no death wish.

As far as support vitamins, I'll be taking anavite as my multi, I also have 500mg vitamin c and 1000iu vitamin e on hand and will probably take them twice a day, but with that and the multi I don't think I should need much more. I will also be running PES Shift, BPI QuadraLean (both non stim and basically for additional support), as well as my standard omegas.I have EC on hand in case the lethargy kicks in.

My question really is around DMAA. I have Jacked Up for preworkout but it has DMAA in it, so I'm wondering if I should forego that and use something like Amino Energy that's just basically bcaa's and caffeine.

Also, I'll be running mostly low carb / ketogenic, but would it be beneficial to throw in a couple of carb up days to replenish glycogen and prevent brain fog?'

Anyone have any feedback or input? Always welcome recommendations.

By the way, I picked up my DNP from the man Dinitro. The guy is great, very responsive, answered some questions I had, and shipped everything really quickly. Also super discreet and professional throughout the process, so I highly recommend him.

Do not use dnp.

But I know you will anyway so I'm gonna give you some pointers.

NO CARBS
that's how people cook themselves to death!!

Start dnp lower. And up as you go. With stuff like that expect it to be overdosed (even if not, safety first)

Run a keto diet, but expect full amount of flatness! You can't do anything against that. Just wait it out.

Then after you finish slowly up your carbs and cut the fats. I have read some were that dnp shuts down your thyroid for the duration used so you don't want to have a lot of fat bc then the dnp will be for nothing.

 

[enigma735]

Thanks for the pointers. I've read the DNP sticky thread through and through and have done a lot of research on pubmed and on the various forums gathering info on people's experiences.

From what I understand the negative thyroid effects aren't really present until after the 2 week mark, and t3 is recommended for those running it longer. Since I plan on a two week cycle at a relatively low dose, is that still a concern?

Also, from what I've read it's actually better to be low carb to keep your glycogen stores replenished (some people even turning to fructose to do so) than completely ketogenic. People sweat more but that's the only con go introducing some carbs. So what you're saying is low carb / mod carb actually increases the effects of DNP and can cause you to cook more internally? I haven't read that anywhere but I'll probably stay low to ketogenic anyway. I expect the flatness and the water retention. Those are just facts of life until the cycle is over.

 

[D-Ballin]

You won't cook yourself eating carbs. Just avoid them if you need some dry time.

Plan to run low carb. Try ketosis if you want, see how long you last. The brain fog is inevitable either way.

You'll actually achieve a larger deficit utilizing carbs instead of fat, all calories being equal.

Would not recommend unless you are behind on a time frame. And not a self imposed one. Nothing else will get you results that fast. Nothing else will make you more miserable in the process. Dieting is much easier. Done right, DNP is not the easy way out. All well and good thinking you can eat whatever, until you realise most everything you want to eat will fuck up your temperature and goals (assuming one lb/day). And you can eat like a pig all day, but you're still starving.

 

[Dr JIM]

What is your DNP objective?

Why have you chosen a short course remedy to weight loss, knowing the "benefits" and the duration of said "benefit" are limited at best?

Finally I'd suggest you read Bill Roberts opinion listed on Meso's home page in the "STEROID PROFILE" section under "PED'S and ANCILLARY DRUGS".

I'll also emphasize if your above the age of roughly 40 or have any other confounding medical history such as DM, Thyroid disease, established CVD, etc the adverse effects of DNP COULD result in your demise or having you visit an ED sooner than you think.

To that end, I am unaware of any "ancillary drug" whose adverse effects exceed those of DNP on either a quantitative or qualitative basis.

 

[hurricane187]

ill give you very simple but effective advise.Run it during the coldest months climate wise. It makes a huge difference.If you asking now during january, im assume you are doing so

 

[Dr JIM]

FYI limiting the ingestion of carbs will NOT result in a "preservation of glycogen stores". In fact quite the opposite is KNOWN to be the case metabolically, primarily bc there is no DNP specific shuttle mechanism.

DNP accelerates the BMR of all cells yet has it's greatest influence on those "organs" that are metabolically active. The latter is the primary reason DNP does not selectively reduce TBF, on a comparative basis adipose tissue is relatively dormant.

Thus the substrates utilized for the entropy created by DNP are first derived from GLYCOGEN followed by protein and fat as the latter two require hepatic (and the kidney to a lesser extent) degradation into GLUCOSE

 

[pumpingiron22]

No no no stop and stay away not with it.

 

[54chev]

I agree with pi..dnp is probably the harshest drug utilized in bodybuilding. I think youre crazy to be willing to risk what youre about to just for a little weightloss. Stuff was used to make bombs in france and they noticed it sped the metabolism up the factory workers building them. People in the 30s made it a diet pill, they didnt know better..a lot of drugs were mainstream back then, put a label on it and sell it.. Now..its labeled as not safe for human consumption. I think youre a fool for using it. The risk is far greater than the reward. Good luck..

 

[DonQKong]

I would never recommend DNP. For the regular Joe, its not something to be used. What I recommend to OP is only to take advice from someone who has actually used it, not some stigmatised know-it-all. There is quite a few of those in this thread, btw.

I use dnp. Am on my pre-cycle diet know, doing 300 mg before bed. Have tried higher dose and it simply ain't worth it. It will impact your life too much. Remember please for the love of everything holy the halftime of 36 hours. If you take 250 mg at 6am on a Monday, half of the effect will reside 6pm on a Tuesday. I'd rather take it a couple of more weeks at lower dose, than a shorter time periods at higher dose.

Don

 

[miamiboi]

So @DonQKong youre more comfortable with taking 250mg for a 2 week cycle than upping it after the 4th or 5th day?

 

[Dr JIM]

I would never recommend DNP. For the regular Joe, its not something to be used. What I recommend to OP is only to take advice from someone who has actually used it, not some stigmatised know-it-all. There is quite a few of those in this thread, btw.

I use dnp. Am on my pre-cycle diet know, doing 300 mg before bed. Have tried higher dose and it simply ain't worth it. It will impact your life too much. Remember please for the love of everything holy the halftime of 36 hours. If you take 250 mg at 6am on a Monday, half of the effect will reside 6pm on a Tuesday. I'd rather take it a couple of more weeks at lower dose, than a shorter time periods at higher dose.

Don

I do hope your not suggesting one has to experience Gonorrhea, a heart attack, appendicitis, the adverse effects of heroin or DNP, to post what is KNOWN and well documented
in the medical and physiologic literature.

There are multiple ways to "lose weight" but the risk from using DNP far exceeds the benefit and that's why it was removed from the market shortly after its introduction in the 1940s.

The same situation occurred with FenPhen but I suppose SOME would still be willing to use that also.

It's prophetic to know if DNP was being pushed by "Big Pharma" there would be class action suits from Florida to Washington, but since it's banned by the FDA we have a few therapeutic minions pushing this compound in the UG market, immune from prosecution until another death occurs.

Your experience with DNP ensures you know just enough to be dangerous by "recommending" specific dosages bc your not going to be there when all the adverse effects come ARE YOU!

My "stigmatized recommendation" is simple DNP is NEVER an appropriate weight loss agent!.

 

[enigma735]

Hey guys thanks for all the advice. I'll stick to running it 250mg / day. I don't need astronomical results but my motivation is that I am on a tight schedule for a fitness shoot in early March, and I broke my foot last month and it really killed my cardio and progress even with a clean diet while recovering.

 

[pumpingiron22]

Look in to clen and t3 With a clean diet and cutting cals would be a much better option.

 

[enigma735]

Look in to clen and t3 With a clean diet and cutting cals would be a much better option.

I have experience with Clen and T3 previously. My major concern with Clen is the effect on the heart and programmed cell death.

Taking it all into account I may hold off on the DNP. I understand that 250mg wouldn't likely kill me, and I'm not concerned with sweating since I work from home and the other sides seem pretty on par to some gear I've used, but maybe I'll see if there's a better plan I can throw together HIIT wise that I can actually do with my foot still keeping me from running, rowing, jumping rope and pretty much any form of worthwhile cardio, except the damn bike. There's got to be some sort of body weight non-weight bearing exercises I can do as fast as possible to jack my heart rate up.

I'll look into that.

I'm not looking for a magic pill, I'm just trying to make sure I show up on the day and hit the #s they want me at.

 

[Dr JIM]

I have experience with Clen and T3 previously.

My major concern with Clen is the effect on the heart and programmed cell death.

at.

But the electrolyte disturbances, dehydration, hyperthermia, all common adverse effects from DNP use, places a less severe strain on ones heart, are you serious!

"Programmed cell death" exclusive to Clen, (and not other Beta agonists such as AlbuterolI hope your decision to use DNP was not based on similar Rodent LD-50 Studies

Good luck

 

[pumpingiron22]

Originaly posted by nandi on CM board.

It's been known for some time that http://elitefitness1.leadpages.co/leadbox/144645a73f72a2%3A1428c0c2bb46dc/5757715179634688/ at high doses causes cardiac necrosis. This study in animals shows that doses of 1 mcg/kg BW induce apoptosis (programmed cell death) in heart tissue. Humans not uncommonly ingest this much Clenbuterol. For instance, in a 220 lb (100 kg) bodybuilder this translates to 100 mcg. The CEM store sells Clenbuterol at a concentration of 200 mcg/ml! Other UG labs sell it at similar concentrations, ranging from 100 to 200 mcg per ml.


J Appl Physiol. 2004 Dec 10; [Epub ahead of print] Related Articles, Links

{beta}2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle.

Burniston JG, Tan LB, Goldspink DF.

Research Institute for Sports and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.

High doses of the beta2-adrenergic receptor (AR) agonist, http://elitefitness1.leadpages.co/leadbox/144645a73f72a2%3A1428c0c2bb46dc/5757715179634688/, can induce necrotic myocyte death in the heart and slow-twitch skeletal muscle of the rat. However, it is not known if this agent can also induce myocyte apoptosis and whether this would occur at a lower dose than previously reported for myocyte necrosis. Male Wistar rats were given single subcutaneous injections ofhttp://elitefitness1.leadpages.co/leadbox/144645a73f72a2%3A1428c0c2bb46dc/5757715179634688/. Immunohistochemistry was used to detect myocyte specific apoptosis (detected on cryosections using a caspase 3 antibody and confirmed using annexin V, single-strand DNA labelling and TUNEL). Myocyte apoptosis was first detected at 2 h, and peaked 4 h after http://elitefitness1.leadpages.co/leadbox/144645a73f72a2%3A1428c0c2bb46dc/5757715179634688/administration. The lowest dose of http://elitefitness1.leadpages.co/leadbox/144645a73f72a2%3A1428c0c2bb46dc/5757715179634688/ to induce cardiomyocyte apoptosis was 1 microg kg(-1), with peak apoptosis (0.35 +/- 0.005 %; P<0.05) occurring in response to 5 mg kg(-1) . In the soleus, peak apoptosis (5.8 +/- 2 %; P<0.05) was induced by the lower dose of 10 microg kg(-1). Cardiomyocyte apoptosis occurred throughout the ventricles, atria and papillary muscles. However, this damage was most abundant in the left ventricular subendocardium at a point 1.6 mm, that is, approximately one-quarter of the way from the apex towards the base. beta-AR antagonism (involving propranolol, bisoprolol or ICI 118,551) or reserpine was used to show that http://elitefitness1.leadpages.co/leadbox/144645a73f72a2%3A1428c0c2bb46dc/5757715179634688/-induced myocardial apoptosis was mediated through neuromodulation of the sympathetic system and the cardiomyocyte beta1-AR, whereas in the soleus direct stimulation of the myocyte beta2-AR was involved. These data show that when administered in vivo, beta2-AR stimulation by http://elitefitness1.leadpages.co/leadbox/144645a73f72a2%3A1428c0c2bb46dc/5757715179634688/is detrimental to cardiac and skeletal muscles even at low doses, by inducing apoptosis through beta1- and beta2-AR, respectively.

 

[pumpingiron22]

This study was done on mice. That would be that would be 200 MCG for humans. Which you would have to be crazy to do. 40 MCG tops if it low dosed maybe 60mcg

 

[enigma735]

But the electrolyte disturbances, dehydration, hyperthermia, all common adverse effects from DNP use, places a less severe strain on ones heart, are you serious!

"Programmed cell death" exclusive to Clen, (and not other Beta agonists such as AlbuterolI hope your decision to use DNP was not based on similar Rodent LD-50 Studies

Good luck

I'd say apoptosis is a very real concern versus dehydration, electrolyte imbalances (both of which are manageable), and hyperthermia (the direct result of the mechanism by which DNP works...).

I understand your concern, and you should probably read the rest of the post where I said I was going to forego the DNP. If I'm wavering on using something I always side with my better judgment and forego it.

With that said, I wholly respect your knowledge and viewpoints, but I was not going into this ignorant of the risks. I've spent a lot of time researching not just on forums. More time was spent on scholarly articles and in the National Library of Medicine, which I am fortunate to have physical access to.

 

[enigma735]

This study was done on mice. That would be that would be 200 MCG for humans. Which you would have to be crazy to do. 40 MCG tops if it low dosed maybe 60mcg

Understood but what about the effects of multiple runs of Clen at 40-60mcg. Didn't mean for this thread to turn into this, but obviously appreciate the knowledge of the guys on here.