BigDadd7
Member
What was your T level?
MESO-Rx
Anabolic Steroids
First time HGH
- Thread starter Rooster77
- Start date
niqTM
Member
1324
Ghoul
Member
There are many factors that impact IGF levels at the same rHGH dose.
TLDR Estrogen is “permissive” for IGF-1 production.
Limiting this to Estrogen’s impact only, if all other conditions are equal:
-A very small amount is necessary for normal IGF-1 production.
- male physiological range doesn’t interfere.
- very high levels inhibit IGF-1
———-
Stated another way:
If estrogen is crushed (below ~15pg) IGF-1 production is inhibited = insufficient for normal liver function = lower IGF-1
If estrogen is in male physiological range or mildly elevated (~15-80) IGF-1 production is uninhibited = No “estrogen IGF brake” = IGF-1 determined by other factors
If estrogen is very high, (above ~80-100) IGF inhibition begins = “stepping on estrogen IGF-1 brake” = lower IGF-1
Drizz
New Member
@Ghoul thanks for all your info.Tesamorelin 2mg is roughly the same boost to growth hormone / IGF as 2iu rHGH, though the effects are a tilted more strongly toward visceral fat reduction vs rHGH having a broader range of effects, and it took about 4 months of Tesa for the impact to go from maybe / “Feels” to undeniable visible benefits.
I strongly recommend @Rooster77 and anyone else going down this road to get a baseline IGF-1 blood test before starting. It’s your only chance to know you started so you can get an objective measure of rHGH (or Tesa) having an impact.
Don’t get lazy, if you don’t do this, while not a catastrophe, you’ll probably regret not getting a “clean” IGF number before you ever touch rHGH.
A month or so after starting, if you’re wondering “is this working”, for ~$60 you can see a concrete number that will remove any doubt. IGF also serves as an indicator of other factors that may be blunting the GH effect, so you can troubleshoot the root cause of a poor response (as a bonus, this may reveal health issues you were unaware of like hypothyroidism or fatty liver). Conversely, if you’re a hyper responder you may decide to dial your dose back a little for safety. You want your IGF “Z score”, a positive number indicates how far above your peer average IGF is, to be as close as possible to 2, but absolutely not over 3, for max benefit with minimal long term risk.
There are a number of services offering easy to schedule discount blood work at a lab convienient to you, I use this one, there’s always a 20% off coupon going so use it:
IGF-1 Test
The IGF-1 Test checks growth factor levels, providing insight into growth disorders, hormone balance, pituitary health, aging, and overall metabolic function.www.ultalabtests.com
I’ve been running Reta since June, I am about to start Tesa at 2mg/night fasted before bed, but been looking at HGH to run with Test C, Primo and Mast for a 12 wk run as a HGH first timer at 50 years old.
Ghoul
Member
Don’t worry about timing with Tesa. Any time of day, just consistent, is fine. Its effect is long lasting and amplifies your natural GH release. Eating before or after dosing makes no difference to its effect.
That said eating before bed can dampen natural GH release, when it would normally peak overnight, so it’s a good idea to stop eating a few hours prior anyway.
Drizz
New Member
Got it. Appreciate that. Everything I’ve read about it has it best, fasted and before bed.
Is there an added benefit of running Tesa with GH when the time comes? Thanks
MJMoor
New Member
im 47 running test cyp total t <1500 e2 low 40s have been running 3mg reta week for around a year same time i started my test, my fasting morning glucose was high 90s i add 4iu gh at night 3 months ago and my morning fasting glucose his went to 110-120 same micros ,will it help any to take my gh in the morning with my glucose or should i up the reta?
Ghoul
Member
No. rHGH drops natural production of GH to zero. Tesa only *amplifies* existing production. 50% more of zero is zero.
It can be useful to cycle off rHGH, (natural production quickly resumes), switch to Tesa for a few months to give GH receptors time to resensitize, while maintaining elevated GH to keep progress made on rHGH.
The reason Tesa reduces visceral fat like the equivalent of a much higher dose of rHGH, is because by keeping the natural growth hormone pulses in place, receptors don’t down regulate sensitivity the way they do when exposed to unnatural continuous rHGH exposure, so the “hear” smaller amounts of GH, releasing fat, vs rHGH which makes them a little “deaf” temporarily to growth hormone signals.
Lobsterneck7
New Member
Considering your diet, recovery, and training are where they should be, you should expect some more fullness and better sleep/recovery relatively soon. Weight might come up a bit but in a good way. Maybe some CTS, numbness or tingling. Overall GH is a slow burn compared to the quick hit of anabolics so it’s more so something you will reap a majority of rewards from over a longer period of time. Small percentages each day that eventually add up to some pretty solid results over a period of months and years.
mumblesrumbles
New Member
Hi relatinvely new to hgh(have taken for 1yr brilliant) as in its been a long time ruffly 10yrs and back then it was 100iu kits i got
Now ive orderd 24iu x 10 so does that make 2.4ml water per vial also how long does the vial last after reconsituation ?
Ideally would like to run 2iu initially bit that would mean its sat for nax 12 days any help appreaciated thanks
Now ive orderd 24iu x 10 so does that make 2.4ml water per vial also how long does the vial last after reconsituation ?
Ideally would like to run 2iu initially bit that would mean its sat for nax 12 days any help appreaciated thanks
Cato1989
New Member
.
Ghoul
Member
That reconstitution amount of water is ideal.
No one can answer how long a particular batch of rHGH lasts post reconstitution, but the sooner it’s used, the better. 12 days isn’t excessive.
Consider getting your IGF-1 tested. That’s a much better way to determine if your dose is safe for long term use than IU.
So if my Z score was 1.92 naturally I shouldn’t add GH…? The last test I got was before I started TRT (18 months ago). Test was 427 and IGF 1 was 244 ng/ml. On 250mg of test per week and feeling amazing, wanted to add GH (mostly in the hopes that it would help with effects from my 6 concussions) but sounds like I might not need it yet…?Tesamorelin 2mg is roughly the same boost to growth hormone / IGF as 2iu rHGH, though the effects are a tilted more strongly toward visceral fat reduction vs rHGH having a broader range of effects, and it took about 4 months of Tesa for the impact to go from maybe / “Feels” to undeniable visible benefits.
I strongly recommend @Rooster77 and anyone else going down this road to get a baseline IGF-1 blood test before starting. It’s your only chance to know you started so you can get an objective measure of rHGH (or Tesa) having an impact.
Don’t get lazy, if you don’t do this, while not a catastrophe, you’ll probably regret not getting a “clean” IGF number before you ever touch rHGH.
A month or so after starting, if you’re wondering “is this working”, for ~$60 you can see a concrete number that will remove any doubt. IGF also serves as an indicator of other factors that may be blunting the GH effect, so you can troubleshoot the root cause of a poor response (as a bonus, this may reveal health issues you were unaware of like hypothyroidism or fatty liver). Conversely, if you’re a hyper responder you may decide to dial your dose back a little for safety. You want your IGF “Z score”, a positive number indicates how far above your peer average IGF is, to be as close as possible to 2, but absolutely not over 3, for max benefit with minimal long term risk.
There are a number of services offering easy to schedule discount blood work at a lab convienient to you, I use this one, there’s always a 20% off coupon going so use it:
IGF-1 Test
The IGF-1 Test checks growth factor levels, providing insight into growth disorders, hormone balance, pituitary health, aging, and overall metabolic function.
Getleanordie
New Member
You should maybe get a new test. TRT will boost IGF-1 so you could have a higher Z score now. Your natural gh production could also change a lot in 18 months. Basically you are just guessing what to do without a new test.
I'm in my mid to end thirties and used HGH for a bit over a year at 1-2 IU daily. I noticed many of the benefits described by @Ghoul and also the typical side effects. The carpal tunnel slowly came after about two months but went away again after one month of symptoms. My main motivation to do this were the TRIIM and TRIIM-X studies and indeed I have not been sick for a long time. Before when getting in contact with someone with a flu or runny nose almost always I caught that as well but now that doesn't happen anymore. I also noticed the skin elasticity improve a lot because I lost plenty of belly fat and don't have any loose skin. In the studies they gave HGH, DHEA and Metformin. The Metformin was to counter diabetic development but this also leads to worsened vitamin B12 absorption in the gut so after about six months I started with B12 injections as well.
All in all I feel great and people tell me I look younger than I am.
All in all I feel great and people tell me I look younger than I am.
HGH is way more subtle than test. You won’t get that immediate “on” feeling.
At 4iu most people notice better sleep, recovery, joints feeling better, and fuller muscles over time. Fat loss and lean gains are slow and usually show after months, not weeks.
Early sides can be water retention or numb hands, but that often settles. Think of HGH as a long-term health and recovery add-on, not a fast size drug.
At 4iu most people notice better sleep, recovery, joints feeling better, and fuller muscles over time. Fat loss and lean gains are slow and usually show after months, not weeks.
Early sides can be water retention or numb hands, but that often settles. Think of HGH as a long-term health and recovery add-on, not a fast size drug.
Feels like for 95+% of people, this blows any other combination of AAS out of the water from a risk/reward perspective.
