I just had a blood test one day after an injection of .4 cc test cypionate. The total test of 1126 exceeded the range of 250 to 1100 but free test of 111.4 was in the lower half of 46-224 range and bioavailable of 209.8 was also lower quarter of 110-575 range. Estradial of 41 slightly exceeded the range of less than 39. Does anyone know if there is a lag between the increase in total testosterone and the free an bio-available numbers rising? In the past, at a slightly higher dose, when tested after 4 days, those numbers were better in comparison. Or is it possible that total drops faster than free and bio-available during the week?
MESO-Rx
Anabolic Steroids
Free test, estradiol, and hemocrit time of increase after cypionate injection
- Thread starter Yowzer
- Start date
That Free T number you got there is measured on a smaller scale (Not ng/DL - maybe Picograms don't recall). I think that maths-out to about 1%FT for your numbers as listed. You can also see how they have the REFERENCE VALUES SET when you consider 46-224 compared to max 1100ng/dl, As 224 would be APPROX 2.25% as a high-side value, and with the low side being about 0.5% (the 46)... (Keep in mind that 1%[resulting FT] of 1126 is twice as much as 1% of say 500ng/dl). FT Averages as 2% of TT and does not mean shit. Estrogen should come up as fast as the rest. T Bound to SHBG and ALBUMIUN is all that matters and that's 98% of TT. Total T will of course drop faster as free T will continue to hover around 2%. Dollar for dollar OR percentage comparison, FT should stay at 1-2% as a critical buffer. But FT should always stay flooded and maxed out on TRT and there is no point in measuring it. RBC will report the slowest of the factors you mention. However, RBC/HMCRT should respond with the most variance as dose dependent. 1/2 cc of test/week may not even merit blood letting ever. Donating once every 8 weeks would be more than enough. Just find a doc affiliated phlebotomy blood center and avoid the red cross if possible. They will take your blood without doc orders as long as not more than every 8 weeks. I'm not even sure if they have any sense at all.
If you are trying to determine how quickly your latest pin reflects in LABS, and you are already on TRT and pinning weekly, I think it peaks at about 48-72 hours. These figures COULD continue to increase slightly for as many as 6 weeks on inception or dose changes But that is splitting hairs.... In my experience Estrogen tends to metabolize out and report current states in more like 1-2 weeks running. ANdrogen activity too for that matter. It is a good question I would say anywhere from 48hrs to 2 WEEKS is when your labs may report resulting metabolic derivative activity. But 24 hours is a bit on the early side for best reporting.
Keep in mind that the TT levels can obviously report in labs pretty quickly, given there is (1) enough Esterase enzyme to free the ester, and (2) enough blood protein to pick it up. The rest is lodged in your rump if you pinned a proper DEPOT, or else what you smell in yer piss. But my point is that its an issue of end chain metabolism to derivatives (Androgens, E2, etc) AND Elimination as well, that determines the rate of metabolism and Via MANY Reporting Factors... Complicated and Poorly Understood - INDEED>..
Some of that is read/studied, some is documented, some is self experiential anecdote.
If you are trying to determine how quickly your latest pin reflects in LABS, and you are already on TRT and pinning weekly, I think it peaks at about 48-72 hours. These figures COULD continue to increase slightly for as many as 6 weeks on inception or dose changes But that is splitting hairs.... In my experience Estrogen tends to metabolize out and report current states in more like 1-2 weeks running. ANdrogen activity too for that matter. It is a good question I would say anywhere from 48hrs to 2 WEEKS is when your labs may report resulting metabolic derivative activity. But 24 hours is a bit on the early side for best reporting.
Keep in mind that the TT levels can obviously report in labs pretty quickly, given there is (1) enough Esterase enzyme to free the ester, and (2) enough blood protein to pick it up. The rest is lodged in your rump if you pinned a proper DEPOT, or else what you smell in yer piss. But my point is that its an issue of end chain metabolism to derivatives (Androgens, E2, etc) AND Elimination as well, that determines the rate of metabolism and Via MANY Reporting Factors... Complicated and Poorly Understood - INDEED>..
Some of that is read/studied, some is documented, some is self experiential anecdote.
Last edited:
HCT is the result of a decrease in hepcidin(produced by the liver) that regulates iron absorption from your diet. Hepcidin shuts off excess iron absorption.
TRT increases iron absorption and TRT directly stimulates stem cells in bone marrow to produce more blast cells that eventually become rbcs that use that extra iron in the production of mature erythrocytes.
It's a slower process that is enhanced if someone takes vitamins with added iron.
When hepcidin is regulating iron absorption it usually will only let you absorb 1mg of iron for every 10 to 20 mg you consume. However with TRT it allows you to take in much more iron. You can see a higher hct in a matter of a few weeks. If you're genetically heterozygous(non-dominant) for a JAK2 gene mutation which isn't all that uncommon for a white guy, then you can expect to get a really high hct because your epo set point doesn't have a shut off, it will just keep climbing until you phlebotomize.
TRT increases iron absorption and TRT directly stimulates stem cells in bone marrow to produce more blast cells that eventually become rbcs that use that extra iron in the production of mature erythrocytes.
It's a slower process that is enhanced if someone takes vitamins with added iron.
When hepcidin is regulating iron absorption it usually will only let you absorb 1mg of iron for every 10 to 20 mg you consume. However with TRT it allows you to take in much more iron. You can see a higher hct in a matter of a few weeks. If you're genetically heterozygous(non-dominant) for a JAK2 gene mutation which isn't all that uncommon for a white guy, then you can expect to get a really high hct because your epo set point doesn't have a shut off, it will just keep climbing until you phlebotomize.
And there's some more to swallow. I had to look up JAK2 Gene Mutation just to see if he was jakkin wit us... Looks like some serious kung foo...
I wonder how alcohol plays into all this..!?!?!?!???
What was your FT precisely. And what was you synT dose? That's a question.
You know one thing I was cyphering on the other day is actual demand. Meaning a middle aged man can wake up in the morning and drive down to the doc and get a TT measurement. But WHAT IF, as soon as he puts his body under a physical load the testicles can't keep up and the bottom drops out. I have long suspected that FT is a INDICATION of demand response potential - which may be so.
So what I am putting out is that perhaps if your TRT satisfies a morning measurement UNLOADED, then it might be possible that FT does not represent accurately. I my world that is. When I say MAXED OUT, I am talking 2% of TT.. But I am interested in the above question for sure..
Similar threads
