Future Project: Brewing Injectable Oxandrolone -Seeking Community Input-

Musmadar

Member
Hi everyone,

I’ve been thinking about taking on a new project: creating an injectable oxandrolone solution at 20 mg/mL. I wanted to run my initial idea and recipe by the community "filter" before moving forward to ensure it’s viable, safe, and optimized. This is purely in the planning phase for now, and I won’t start until I’ve gathered enough information, feedback and made necessary adjustments based on the community expertise.


The reason why i'm interested in an injectable form of oxandrolone is because I hope is likely to have a reduced impact on the lipid panel compared to the oral form due to differences in metabolism:

Oral oxandrolone undergoes first-pass metabolism in the liver. This contributes to its significant effect on lowering HDL ("good cholesterol") and raising LDL ("bad cholesterol").This hepatotoxicity is a major reason oral oxandrolone has a more pronounced impact on lipids.


Injectable form bypass the liver during initial metabolism, potentially reducing the strain on hepatic function and lipid metabolism.
The direct impact on lipid profiles may be milder.


If the community agrees this is a worthwhile project and provides some guidance, I’d love to proceed under your advice.


Proposed Recipe

For 100 mL of solution at 20 mg/mL:

Oxandrolone raw: 2,000 mg (2 g)

MIG 812: Primary solvent (~40–50 mL initially)

Benzyl Alcohol (BA): 1% (1 mL)

Benzyl Benzoate (BB): 15% (15 mL)

MCT Oil: Carrier oil to adjust the total volume to 100 mL


Planned Steps


Weigh 2 g of oxandrolone powder and add to 40 mL of MIG 812, stirring continuously.

Apply gentle heat (below 40°C) if necessary to help dissolve the powder.


Mix in 1 mL of BA as a preservative and 15 mL of BB to enhance solubility and stability.


Gradually add MCT oil while stirring until the total solution reaches 100 mL.


Filter the solution through a 0.22-micron sterile syringe filter into sterile vials.


Are there any critical improvements or changes you’d suggest for this recipe?


If this project gets a green light from the community and the recipe is refined with your help, I’d love to document the entire process and share results here. My goal is to learn and ensure the final product is safe, effective, and aligned with best practices.


I want to clarify that I’m open to constructive criticism and am here to learn from the experienced brewers in this community. My goal is to have an informed and productive discussion. If at any point I come across in pointless or nonsensical debates, I sincerely apologize in advance—that’s absolutely not my intention.

Thanks in advance !
 
Hi everyone,

I’ve been thinking about taking on a new project: creating an injectable oxandrolone solution at 20 mg/mL. I wanted to run my initial idea and recipe by the community "filter" before moving forward to ensure it’s viable, safe, and optimized. This is purely in the planning phase for now, and I won’t start until I’ve gathered enough information, feedback and made necessary adjustments based on the community expertise.


The reason why i'm interested in an injectable form of oxandrolone is because I hope is likely to have a reduced impact on the lipid panel compared to the oral form due to differences in metabolism:

Oral oxandrolone undergoes first-pass metabolism in the liver. This contributes to its significant effect on lowering HDL ("good cholesterol") and raising LDL ("bad cholesterol").This hepatotoxicity is a major reason oral oxandrolone has a more pronounced impact on lipids.


Injectable form bypass the liver during initial metabolism, potentially reducing the strain on hepatic function and lipid metabolism.
The direct impact on lipid profiles may be milder.


If the community agrees this is a worthwhile project and provides some guidance, I’d love to proceed under your advice.


Proposed Recipe

For 100 mL of solution at 20 mg/mL:

Oxandrolone raw: 2,000 mg (2 g)

MIG 812: Primary solvent (~40–50 mL initially)

Benzyl Alcohol (BA): 1% (1 mL)

Benzyl Benzoate (BB): 15% (15 mL)

MCT Oil: Carrier oil to adjust the total volume to 100 mL


Planned Steps


Weigh 2 g of oxandrolone powder and add to 40 mL of MIG 812, stirring continuously.

Apply gentle heat (below 40°C) if necessary to help dissolve the powder.


Mix in 1 mL of BA as a preservative and 15 mL of BB to enhance solubility and stability.


Gradually add MCT oil while stirring until the total solution reaches 100 mL.


Filter the solution through a 0.22-micron sterile syringe filter into sterile vials.


Are there any critical improvements or changes you’d suggest for this recipe?


If this project gets a green light from the community and the recipe is refined with your help, I’d love to document the entire process and share results here. My goal is to learn and ensure the final product is safe, effective, and aligned with best practices.


I want to clarify that I’m open to constructive criticism and am here to learn from the experienced brewers in this community. My goal is to have an informed and productive discussion. If at any point I come across in pointless or nonsensical debates, I sincerely apologize in advance—that’s absolutely not my intention.

Thanks in advance !
For what I have read around it will never hold at 15BB. Have you searched the threads in the homebrew section about injectable oxandrolone?

Maybe I remember wrong and it will be fine.

I would do some test with 10/20ml oil first.
 
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You are right !

I was hoping that injectable oxandrolone is more potent and efficient than the oral form on a per-milligram basis, making it a better option if somebody is interested in minimizing hepatotoxicity and maximizing bioavailability but the differences are not that big to matter that much in such a small dose.

It's something definitely to take into considerations when starting brewing.

Thanks for your Input.
 
I was hoping that injectable oxandrolone is more potent and efficient than the oral form on a per-milligram basis, making it a better option if somebody is interested in minimizing hepatotoxicity and maximizing bioavailability but the differences are not that big to matter that much in such a small dose.
Orally dosed oxandrolone is already extremely bioavailable.

If you want the drug straight into the bloodstream then go with buccal troche instead of dealing with all the issues that come with trying to do an IM oxandrolone.

The recipes are very simple.

 
The reason why i'm interested in an injectable form of oxandrolone is because I hope is likely to have a reduced impact on the lipid panel compared to the oral form due to differences in metabolism:
And this is not possible simply by changing delivery route.


Search for "hepatic lipase" and oxandrolone. Avoiding first pass won't stop oxandrolone from upping hepatic lipase.
 
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And this is not possible simply by changing delivery route.


Search for "hepatic lipase" and oxandrolone. Avoiding first pass won't stop oxandrolone from upping hepatic lipase.
i love your contributions but every time you post a link to that cringe website that requires me to register, it ruins the flow :(
 
i love your contributions but every time you post a link to that cringe website that requires me to register, it ruins the flow :(
I'm sorry. I have many posts unfortunately held hostage by the sign up lock they put on the site. Very uncool. If I knew they were going to do that I would have never posted there. I took the time to do the work and tyoe it up. Now TNation locks it.

Anyway, lots of pertinent data in that thread that I collected. Meticulous really.

So for those that want the info, it is a small burden to sign up with throwaway email. Again, not ideal but best I can do.

At this point I'm not porting all that stuff off the site.
 
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Angry Marvel Cinematic Universe GIF by Leroy Patterson

ketamine.
 
And this is not possible simply by changing delivery route.


Search for "hepatic lipase" and oxandrolone. Avoiding first pass won't stop oxandrolone from upping hepatic lipase.
Making a long story...short:

You are saying it's not such a big difference to make it worth brewing, oral form is less of a hassle.

Thanks for your Input.
 
Making a long story...short:

You are saying it's not such a big difference to make it worth brewing, oral form is less of a hassle.

Thanks for your Input.
Yeah I made it too long. You missed my point. If you want to go to more trouble then buccal troche/admin is better than IM. Straight into bloodstream. Eliminates first pass but 2nd, 3rd, ... fourth passes still present.

Formulating oxandrolone for IM injection is PITA and inefficient plus many vendors use solvents that are ASS.

My pleasure.
 
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