MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Liter O' Test
Member
to demonstrate how naive you are.
for what benefits do you want to take a GLP?
bananafeet
Member
1. Appetite suppression
2. Blood sugar control (I'm on HGH)
3. Insulin sensitivity
4. Improve my lipid profile
5. Prevent the reoccurrence of NAFLD (I've resolved it)
It pairs well with my TRT.
Mazdutide is a good fit due to GCCR activation increasing FFA (hepatic lipolysis ) and reducing visceral fat and central adiposity.
Due to the increase in RHR and my minor LV thickening Retatrutide is not as favourable. If you read through the report I sent through you will see mazdutide has a lower effect on RHR.
I hope this information helps you in demonstrating my ignorance and naivety.
dinfar1337
New Member
it dosent do much for appetite control or insulin sensivity. all in all, it should do worse effects on heart rate etc. since the gccr will activate these known "fat burner" pathways of thermogenesis etc.
i just think the research isnt there yet or its fucking donkey weak compound
Liter O' Test
Member
tirzepetide is better for blood glucose control, insulin sensitivity and appetite supression.
glucagon literally raises blood sugar and youre missing the action of GIP increasing insulin output and the additional appetite supression and anti inflammatory effects, just to try to leverage glucagon which isnt well studied and is part of the bodies stress system, probably why it raises HR like reta
bananafeet
Member
Glucagon is diabetogenic, but it's effects are mediated by GLP1 agonism.
"Mazdutide is an analogue of
oxyntomodulin (OXM), a natural peptide
hormone existing in humans that
activates both GLP-1R and GCGR."
It really comes down to person preference. Tirzepatide has cognitive effects that I'm not keen on. As for it increasing insulin it only does that in relation to blood sugar changes. GLP1 also has this effect.
I will be tracking my blood sugar levels at home and checking my hba1c.
I'm still waiting for a demonstration of my ignorance.
Liter O' Test
Member
the demonstration of your ignorance is going onto your 4th glp and still being fat so
bananafeet
Member
Haha ok bro. Come back when you can articulate your thoughts without using personal attacks. I will wait.
phenominal34
Banned
What he said is facts whether personal attack or not. You’re an idiot.
I”don’t feel anything, must not be working … gonna try a different GLP”
I tried telling you this but now more and more ppl are telling you it doesn’t happen in a day or a week. If there’s 4-5 ppl telling you the same thing who do you think is correct ?!
bananafeet
Member
Calling me an idiot is not an argument. Nor is multiple people calling me an idiot some kind on consensus which overrules facts.
I'm not especially intelligent.
However I won't be misrepresented.
1. I followed the titration schedule for semaglutide for 5 months. Highest dose was 3mg.
2. I followed the titration of tirzepatide for 3 months. Highest dose was 5mg
I tried Retatrutide and dropped it because of the sides. In my opinion Retatrutide is trash.
So I'm trying mazdutide next. I think that's fair and reasonable...
But each to their own.
I'm not especially intelligent.
However I won't be misrepresented.
1. I followed the titration schedule for semaglutide for 5 months. Highest dose was 3mg.
2. I followed the titration of tirzepatide for 3 months. Highest dose was 5mg
I tried Retatrutide and dropped it because of the sides. In my opinion Retatrutide is trash.
So I'm trying mazdutide next. I think that's fair and reasonable...
But each to their own.
Musmadar
Member
One thing I see way too often — guys bouncing between compounds, GLP’s, PEDs, training styles, diets… without ever giving any of them enough time to actually work.
It’s like planting seeds and digging them up every week to “check progress” — then wondering why nothing grows.
Whether we’re talking GLP-1s, TRT, AAS, peptides, training protocols, or diet approaches, the same rule applies:
Pick your tools.
Run them long enough to evaluate results.
Adjust based on data, not impatience.
If you change your stack every 3–4 weeks, you’re not “optimizing” — you’re just sabotaging your own feedback loop. Half the time you won’t even know what’s responsible for progress (or lack thereof).
Consistency in dosing, diet, training, recovery — all of it — is what lets you separate what’s working from what’s just noise. Without that, you’re just chasing shiny objects, and your results will be as scattered as your approach.
Give your plan the time it needs before you start swapping compounds or protocols. Your body isn’t an on-demand Amazon Prime delivery — results don’t arrive in 48 hours.
It's just a thought...take it or leave it.
It’s like planting seeds and digging them up every week to “check progress” — then wondering why nothing grows.
Whether we’re talking GLP-1s, TRT, AAS, peptides, training protocols, or diet approaches, the same rule applies:
Pick your tools.
Run them long enough to evaluate results.
Adjust based on data, not impatience.
If you change your stack every 3–4 weeks, you’re not “optimizing” — you’re just sabotaging your own feedback loop. Half the time you won’t even know what’s responsible for progress (or lack thereof).
Consistency in dosing, diet, training, recovery — all of it — is what lets you separate what’s working from what’s just noise. Without that, you’re just chasing shiny objects, and your results will be as scattered as your approach.
Give your plan the time it needs before you start swapping compounds or protocols. Your body isn’t an on-demand Amazon Prime delivery — results don’t arrive in 48 hours.
It's just a thought...take it or leave it.
Apologies if i missed something but if you still struggle with Blood sugar control i'd suggest adding very low dose of metformin and a slgt2 on top.
Otherwise a bit more retra. I was running tirza before and noticed much more stable and lower glucose levels with retra compared to Tirza.
Liter O' Test
Member
so why did you stop tirzeptide ? and not go above 5mg?
also, you think mazdutide could be so great, yet you drop reta because of the side effects, well mazdutide is closer to retatrutide than the other two GLPs you stopped.
are you putting your entire understanding of mazdutide from 1 little line graph from one source? because like I said, if the glucagon action is even stronger than reta, it should increase HR even more
honestly youre a retard
dinfar1337
New Member
up to 17,4?????????
yeah im just gonna chill at 83bpm oh wait suddenly my bpm is above 100 lmao(most steroid users are probably above 80 but im sitting at 75-80 we will all be fucked)
bananafeet
Member
I literally posted the research showing Mazdutide has less impact on resting heart rate.
Can you read or do I need to spell everything out? Also try to understand the fundamentals instead of pasting ChatGPT slop. ChatGPT just makes stuff up brother
bananafeet
Member
You two cunts can't be serious. Fuck me dead. The resting heart rate increase is less than 5 BPM. Read the trial report I posted...
ChatGPT is making shit up
bananafeet
Member
I think your are experiencing ChatGPT psychosis lol
Tren + ChatGPT = accelerated ChatGPT psychosis
If you literally read the post I made by scrolling up instead of having a made up conversation with a language model which is just gonna make shit up and agree with you, you could have avoided looking like an insane person.
You sir are incredibly foolish.
bananafeet
Member
Can you read @Liter O' Test
I literally posted the data. Where is this 17bpm coming from? Did you hallucinate it or did ChatGPT lol
This bloke
I’d recommend going back on Tirz since it checks all your boxes. This time, don’t stop at 5mg. Move up through 7.5, 10, 12.5, and 15mg. I think it was @Ghoul who mentioned that for many men the real effect often kicks in only at 10mg, and lower doses might not be noticeable. In my own case, I felt every single dose from 2.5 all the way up to 15mg. Give yourself more time, and don’t jump from one GLP to another too quickly. Run it for at least 6-7 months, then decide from there.
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