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Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Ghoul
Member
Yeah response is widely variable.
The leading hypothesis is, like all hormones, we all start with a different baseline, along with different amounts of receptors.
The amount of appetite suppression (and its related side effects, which are essentially an extreme level of what you'd naturally experience after overeating) is determined by the PROPORTION of GLP receptors agonized.
In general, men have a higher density, and women have a lower density of these receptors.
So generally, men require a higher dose for an equivalent appetite suppression response to women.
On the other hand, if you produce high levels of baseline GLP, or have low numbers of receptors, you're likely to be VERY sensitive to small doses.
That's why Tirz is often completely ineffective in many men until doses are over 5mg, while a small minority are utterly crippled by 2.5mg. Same phenomenon with all GLP class drugs.
Genetic tests can determine your GLP production levels and receptor density, predicting whether someone is likely to be a normal, a hyperresponder, or
non-responder (no one is 100% non responder though, which is who the new 7.2mg Sema and 25mg Tirz doses are being released for).
Liter O' Test
Member
yeah i didnt put in any time because all your shit has been wrong anyway, so yeah i trust a quick chatgpt search more than you
you stopped at 5mg even though you need to lose more weight and picked the GLP known to not supress appetite as much as the other GLPs you tried.
if you still havent lost weight, the answer is not different GLPs
bananafeet
Member
ChatGPT isn't a reliable source of information. Like I said before you have nothing valuable to add to the conversation.
Palifter
Member
These are fantastic tools, especially when someone is already following a structured plan and adheres to said plan.
They won’t fix a bad diet or poor habits but add them into a clients plan and things become clear just how useful they can be.
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They won’t fix a bad diet or poor habits but add them into a clients plan and things become clear just how useful they can be.
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phenominal34
Banned
Everyone else is wrong that’s telling you the same thing lol
You def are a certain kind of special
bananafeet
Member
If Mazdutide turns out to be a dud it will be a toss up between tirzepatide and semaglutide.
The trials look promising for Mazdutide.
My main issue with tirzepatide is the fatigue and lack of interest in my hobbies. It's very strong however, I felt the effects from the first 2mg.
I lost 8kg over 3 months on it. I only used one vial (30mg).
bananafeet
Member
It's a known side effect. Probably through stronger glucose control. Obviously you will be fatigued in a calorie deficit, but I found tirzepatide to be much worse than semaglutide.
dinfar1337
New Member
Efficacy and safety of Mazdutide on weight loss among diabetic and non-diabetic patients: a systematic review and meta-analysis of randomized controlled trials - PMC
Overweight and obesity are increasing global public health problems. Mazdutide is a new dual agonist drug that can potentially reduce weight and blood glucose levels simultaneously. However, the synthesis of evidence on the efficacy and safety of ...
pmc.ncbi.nlm.nih.gov
and that was the end of treatment when they have lost more than 10% of their bodyweight in 48 weeks. and they still have increased heart rate of 17,4 on average????????
dinfar1337
New Member
none of the risks involve the higher heart rate it cant be true only because chatgpt said it
yikes
yikes
bananafeet
Member
Thanks mate I guess I was wrong. I wasn't aware of this.View attachment 340364
5 to 17,4 on average! you are right, it could be even higher than 17,4Efficacy and safety of Mazdutide on weight loss among diabetic and non-diabetic patients: a systematic review and meta-analysis of randomized controlled trials - PMC
Overweight and obesity are increasing global public health problems. Mazdutide is a new dual agonist drug that can potentially reduce weight and blood glucose levels simultaneously. However, the synthesis of evidence on the efficacy and safety of ...
and that was the end of treatment when they have lost more than 10% of their bodyweight in 48 weeks. and they still have increased heart rate of 17,4 on average????????
I went off of the other trial data I posted which stated the the average heart rate increase was less than 5 BPM.
I'll have a read of the paper later. Thanks for posting it
dude. Just use goddamn tirzepatide and go to a higher dose. The older GLPs like Mazdutide are not nearly as good as the newer ones
Alright boys. Gonna increase Tirz from 10mg to 15mg next week. I tought 10mg was gonna be it for me but unfortunately not. I am still maintaining the 30lbs weightloss but these past 2 weeks I have been so goddamn hungry and I still wanna loose another 5lbs.
I'll have to do some weird shenanagins with the dilution because I got 40mg vials and splitting those in 15mg gonna be a bit of a headache.
I bought 40mg because I tought 10mg was gonna be my upper limit. if I had known I'd have bought some 60mg, smh.
I'm gonna skip 12.5mg because I'm getting heavily diminishing returns. 5mg was strong af at first. Then going from 5 to 7.5 made no difference. 7.5 to 10 I finally got a little extra appetite suppresion. but not much
I'll have to do some weird shenanagins with the dilution because I got 40mg vials and splitting those in 15mg gonna be a bit of a headache.
I bought 40mg because I tought 10mg was gonna be my upper limit. if I had known I'd have bought some 60mg, smh.
I'm gonna skip 12.5mg because I'm getting heavily diminishing returns. 5mg was strong af at first. Then going from 5 to 7.5 made no difference. 7.5 to 10 I finally got a little extra appetite suppresion. but not much
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I'm currently fasting for 1 or 2 days every week to maintain the weighloss, because I can't help it but overeat on most days. I find to much easier to fast because as soon as I eat something I get even hungrier. Even a large plate of lean meat and vegetables makes me hungrier than before. I'm trying to cut out fruit and dairy because those also make hungry af, but the cravings are tough. At least I'm getting some metabolic health benefits form the fasting lol
dinfar1337
New Member
have you tried other glps than tirzepatide?
this dosent sound normal at all on 10mg. get your ass up to 15mg and if that dosent work you might just be a nonresponder.
15mg is for obese diabetics with fatty liver disease. absolute highest dose. if you're that high you're likely on the wrong glp.
im pretty sure i saw @Ghoul mentioning the new studies coming out with non responders going all the way up to 20-25mg.
Ghoul
Member
Response is determined by genetics, not health, but poor responders are poor responders to natural GLP and GIP as well, so it's true that group is more susceptible to getting fat and developing diabetes.
If your ancestors all seemed to die from the complications of obesity and diabetes there's a good chance you'll be a poor responder.
I am definetly a responder to Tirzepatide. Before Tirz I was 30lbs heaver than I am now, and that was me doing my absolute best with diet and training to keep my weight down. If I hadn't been trying at all I would have been worryingly obese. I have an absurd appetite, always been like this since I was a kid. I tried sema before tirz and 0.25mg of pharma Ozempic gave me the worst stomach pain and nausea of my life (it made me litterally bedbound for a few days) used it for 3 weeks amd ditched it.
Tirzepatide DEFINETLY works for me, I just think that being lower bodyfat is unnatural for my body, so it fights back.
Before Tirz the leanest I had gotten was 15% bf or so and it was a grind. maintained for only like 1 month before balooning back up to 30+% bf. now I am at 13-14% (I guess) and I have to put a good amount of effort to maintain it, but still nowhere near as much effort as I had to put in before to even get below 20%
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phenominal34
Banned
Try Reta, I still have a large appetite but can’t eat close to as much !!!
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