MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
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Photon
Member
Are you going down the rabbit hole trying to look for ways to justify the use of Maz? The best way to evaluate, is to test it yourself. I've pulled the numbers before, decided the information was rubbish and ended up with Reta.
The issue with comparing these numbers, is that some are evaluated in vitro, mouse, humans or are inconsistently reported between different websites. Good luck finding a source for the info too. Alot of chemical websites report different numbers, which you cannot find a source for. You can't really compare these GLPs simply based off these. It also depends on how you react to them and so on.
I saw this on a website a long time ago, I don't remember where, i also don't remember if it's accurate anymore. Since i settled on Reta, i stopped bothering, because there really isn't much in the upcoming pipeline. Maybe you can update it or find the updated version and share it, and highlight which is on mouse, in vitro or in humans.
bananafeet
Member
I just started Mazdutide. I'm just curious more than anything else....
Photon
Member
It's alot weaker according to that table, and given how the dosing is lesser too, I'd expect lesser sides too.
I have veins on my abdomen, isn't working my ass. eating 300g of protein is a retarded way to supress appetite and barely even effective. Would be cheaper and healthier to up the Tirzepatide or add a low dose of Metformin or Cagrilintide.
Super high protein intake is just a good way to damage your health and longevity for no benefit. Over 1g/lbs of bodyweight is useless, unless you are on a lot of AAS and HGH, in that case you might benefit from up to 1.25-1.35g/lb. But then again it's a shitty trade off.
probably won't be very steong running it alone. Manye here stack it on top of their Sema/Tiz/Reta
bananafeet
Member
I've started on the 2mg dose. Seems to be working fine at the moment. The clinical doses used 4 and 6mg so it must be pretty strong.
Source:
oh wow. pretty close to tirz. I didn't think so. You know I might look into it as well, see if it's worth stacking on the 10mg Tirz I take
Reta has stronger GIP than Tirzepatide? I tought it was mainly GLP1. I have a chart that's a bit different
Ghoul
Member
Yes, the stronger GIP in reta is there to balance Glucagon. Other glucagon drugs were pulled from human trials because they cause hyperglycemia.
That's why "stacking" with something like Tirz, with much weaker, more natural GIP is a mistake.
bananafeet
Member
Like Ghoul said I wouldn't stack similar GLP1s. Maybe a bit of semaglutide is ok.
It would be better to increase the dose or add a compound with a different pathway.
I've started testing my blood sugar with a pin prick test because I'm concerned stacking HGH and with a GCCR drug might give me diabetes lol
The high level of GIP and low level of GLP1 in Retatrutide makes sense, because people can still eat but generally don't want to. Semaglutide at higher doses almost stopped my stomach so eating was a physical impossibility....
dinfar1337
New Member
every glp drug will in the end lower your bloodsugar more than it raises it even if its a gccr agonist. you seriously need to do better research
its a drug for diabetics
I did a few months of maz. It was okay. I thought I liked it. But the source I got it from disappeared and no one else was selling it. So I went back to tirz and forgot how much better tirz was.
dinfar1337
New Member
yes just search mazdutide glucose or mazdutide bloodsugar, theres plenty of useful info or graphs you will find pretty fast.
glp is hack for hgh to not turn diabetic
tirz and retrarutide are top dawgs for blood sugar control and insulin secretion
Liter O' Test
Member
tirz and tren had me lose 3lbs this week, need to increase calories
you don't need more calories, you need more tren. food is for pussies
Liter O' Test
Member
Anyone have an opinion on higher dose GLPs blunting insulin release so much it could affect anabolism?
Like youre more insulin sensitive so you barely need any insulin i think is how it works
Like youre more insulin sensitive so you barely need any insulin i think is how it works
bananafeet
Member
From my reading of it bro they stimulate glucose dependent insulin release. So basically they increase how much insulin you produce when you eat.
The insulin sensitivity probably comes from the reduction in food intake.
So they should make you more anabolic or make the effects of your native insulin more effective.
Chase Irons was sorta the first guy to float year round glp1 use. In bulking to maintain insulin sensitivity and during cutting to lose weight.
That being said I'm not sure how GCCR (glucagon receptor agonists) effect this balance.
Maybe Ghoul has some input on it.
Ghoul
Member
No it won't inhibit anabolism.
Insulin release isn't being blunted, insulin sensitivity is being increased. so less insulin is required to achieve the same effect that required more insulin before the GLP, ie muscle nutrient uptake and inhibition of catabolism.
That's why insulin release is lowered. It's a response to improved sensitivity.
We know this in part because weight loss induced by max dose GLPs is biased toward fat vs lean mass. If anabolism was being inhibited the opposite would occur.
Liter O' Test
Member
thank you, ive been going back and forth about increasing my dose from 2mg. I'm eating 3k calories just fine on my ~2nd week of serum at 2mg dose. Just trying to convince myself to up it. I'll probably do 3mg next week
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