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Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

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phenominal34 said:
Scale ??? Tell us what really matters, how much have you lost since starting it ?
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19 Aug 2025:
Weight – 110 kg
Neck – 41 cm
Chest – 116 cm
Abdomen – 96.5 cm
Hip – 94 cm
Left Bicep – 41 cm
Right Bicep – 41 cm
Left Thigh – 66.5 cm
Right Thigh – 66.5 cm
Left Calf – 44 cm
Right Calf – 44 cm

I'm more concerned about regaining weight than losing it. I'll keep recording as the months pass. It's still early days. I was 136kg at one point (Apr 24) so I've lost a massive amount of weight. These things take time.
 
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SmallTitsIRL said:
How are you guys eating on Reta? I've done 2 shots of reta (1mg each) and I'm feeling like I'm disappearing, no hunger, no appetite, fasted BG dropped from 108 to 88 after the first shot. I just wanted not to think about food, but Ive lost 4 kg in 4 days, this shit is criminal, no more excuses to be fat
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This happened to me. I stopped for 2 weeks, then started again at 0.5mg. I've done 2 injections so I'm in Week 2. No side effects.
 
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Hi guys, is there anyone who hasn’t felt the effects of semaglutide? This is the second time I’ve given it a try. The first time I went up to 2.5 and didn’t notice any appetite suppression, so I quit. Now I started again a few weeks ago and I’m at 1.5, but I still don’t notice anything… how high should I increase the dose?
 
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Alex2000 said:
Hi guys, is there anyone who hasn’t felt the effects of semaglutide? This is the second time I’ve given it a try. The first time I went up to 2.5 and didn’t notice any appetite suppression, so I quit. Now I started again a few weeks ago and I’m at 1.5, but I still don’t notice anything… how high should I increase the dose?
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I take 5 mg per week and feel a slight suppression.
 
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Alex2000 said:
Oh isn’t that too much? I thought the maximum dose was 2.4.
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In recent trials by Novo Nordisk, doses up to 7.2mg were used safely. This was for "non-responders".

If this is the only kit of Sema you've ever tried though, I'd be VERY cautious using another. You could have gotten a bad batch. or the wrong peptide. No response to 2.4mg is extremely unusual. It's a very potent GLP.
 
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Alex2000 said:
In recent trials by Novo Nordisk, doses up to 7.2mg were used safely. This was for "non-responders".

If this is the only kit of Sema you've ever tried though, I'd be VERY cautious using another. You could have gotten a bad batch. or the wrong peptide. No response to 2.4mg is extremely unusual. It's a very potent GLP.
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I would even say that it is too little. I think I'll stick to 5mg and try to add Cagri during the days.
 
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12o3j129dq said:
I would even say that it is too little. I think I'll stick to 5mg and try to add Cagri during the days.
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I would say you have bunk Sema. By 7.2mg Novo couldn't find a single non responder.

What you're describing is like someone saying they inject 2 grams of testosterone a week and get a weak or no response.

You may have gotten Tirz instead. Wouldn't be the first time a mixup from the supplier happened.
 
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Ghoul said:
I would say you have bunk Sema. By 7.2mg Novo couldn't find a single non responder.

What you're describing is like someone saying they inject 2 grams of testosterone a week and get a weak or no response.

You may have gotten Tirz instead. Wouldn't be the first time a mixup from the supplier happened.
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If I had gotten Tirz, I would be dead. I have a severe allergic reaction to Tirz. Yes, I have tried different suppliers. I am also allergic to Reta. Yes, it is sema.
 
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phenominal34 said:
How long have you been on Sema for ?
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I started everything with 0.25 mg in May 2024 and had the typical symptoms at the beginning. I also lost weight quickly and significantly. I lost 10 kg in the first five months. However, I had to increase the dose quite quickly. By the end of the year, I was already taking 2.5 mg. Since the beginning of this year, I have had to increase the dose further in order to feel any effect at all.
 
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I've asked this here in the past and you guys suggested I just up my dose of Tirzepatide from 10mg to 15mg and I get it's what makes the most sense but still I feel as I am getting significat diminishing results for Tirzepatide. 5mg initially was amazing, then after loosing weight and 5mg was no longer enough going to 10mg made barely a tiny difference in my appetite.
I feel as if it might just be a bit of a waste upping it more for very little appetite suppression.
So any other compounds that stack well with tirz and provide some extra appetite suppression? not sema because that made me feel horrible on 0.25mg.
I'm already doing everything I can diet wise. Fasting, high fiber, clean diet
 
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Luke391 said:
I've asked this here in the past and you guys suggested I just up my dose of Tirzepatide from 10mg to 15mg and I get it's what makes the most sense but still I feel as I am getting significat diminishing results for Tirzepatide. 5mg initially was amazing, then after loosing weight and 5mg was no longer enough going to 10mg made barely a tiny difference in my appetite.
I feel as if it might just be a bit of a waste upping it more for very little appetite suppression.
So any other compounds that stack well with tirz and provide some extra appetite suppression? not sema because that made me feel horrible on 0.25mg.
I'm already doing everything I can diet wise. Fasting, high fiber, clean diet
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Why not try Reta?
 
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Ghoul said:
Diría que tienes un problema con Sema. Con 7,2 mg de Novo no se encontró ni un solo paciente que no respondiera.

Lo que estás describiendo es como si alguien dijera que se inyecta 2 gramos de testosterona a la semana y obtiene una respuesta débil o nula.

Quizás te haya tocado Tirz. No sería la primera vez que ocurre una confusión con el proveedor.
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Ghoul said:
En ensayos recientes de Novo Nordisk, se utilizaron dosis de hasta 7,2 mg con seguridad. Esto se hizo para pacientes que no respondieron al tratamiento.

Si este es el único kit de Sema que has probado, te recomiendo MUCHO cuidado al usar otro. Podrías haber obtenido un lote defectuoso o el péptido equivocado. Es extremadamente inusual que no haya respuesta a 2,4 mg. Es un GLP muy potente.
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Ghoul said:
In recent trials by Novo Nordisk, doses up to 7.2mg were used safely. This was for "non-responders".

If this is the only kit of Sema you've ever tried though, I'd be VERY cautious using another. You could have gotten a bad batch. or the wrong peptide. No response to 2.4mg is extremely unusual. It's a very potent GLP.
Click to expand...
Thanks, the previous kit was from QSC, the current one is from SSA
 
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Luke391 said:
I've asked this here in the past and you guys suggested I just up my dose of Tirzepatide from 10mg to 15mg and I get it's what makes the most sense but still I feel as I am getting significat diminishing results for Tirzepatide. 5mg initially was amazing, then after loosing weight and 5mg was no longer enough going to 10mg made barely a tiny difference in my appetite.
I feel as if it might just be a bit of a waste upping it more for very little appetite suppression.
So any other compounds that stack well with tirz and provide some extra appetite suppression? not sema because that made me feel horrible on 0.25mg.
I'm already doing everything I can diet wise. Fasting, high fiber, clean diet
Click to expand...
Cagri
 
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Luke391 said:
is it that powerfull? I know many were disappointed by CagriSema but never heard of it stacked with Tirz. Will look into it more, thanks
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I’ve been reading many ppl are loving the benefits of small dose of Cagri with Tirz or Reta for more appetite suppression. Sry has it at the moment for a good deal and that’s where a lot of ppl are speaking highly of the combo.
 
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phenominal34 said:
I’ve been reading many ppl are loving the benefits of small dose of Cagri with Tirz or Reta for more appetite suppression. Sry has it at the moment for a good deal and that’s where a lot of ppl are speaking highly of the combo.
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Sry? you mean SSA?
Also what's the dosage of Cargilintide? I know it's a Amyelin receptor agonist, but trough what mechaniam does it supress appetite?
 
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