MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Well you know if you are at the right dose because your appetite is suppressed to the point that you are happy with. But also you should balance that with side effects like heart rate increase that typically kicks in after 3-4 weeks.
Ok that's helpful, not excited about the raised heart rate. Does it calm down over time?
I think it does, I dropped to 1mg and split the dose to every 3 days to help reduce the size of the peak and try and reduce that side effect. It worked well and after 4 weeks of that I’m increasing the dose again to 1.5 or 2 we’ll see. Nebivolol does work decently though if you need it at any point.
yes that is what I do usually (but maybe not enought?) it's usually a 0.75ml injection. I'll try to go more vertical with the needle and pinch better
tbh I haven't noticed much metabolic "slow down", a little yes, but way less than I did with diets without GLP1s. At this point I belive Tirz makes you hold less bodyfat trough some other mechanism on top of appettite suppression. Either it is significantly improved nutrient partitioning or less absorbtion of nutrients. Or some other thing I have no idea. I am 30lbs ligher but my average daily intake is about 500-800calories less than before? while before Tirz I probably would have had to drop 1000+ calories less to loose this weight
BrunoES
Member
How 2.5 felt like for you? Overall. Appetite, calories, etc
2.5 I felt nothing, maybe slightly lower digestion but it did nothing for appetite. 5mg worked great, eventually had to up to 10mg. I wanna up to 15mg now but with the shit goinf on with the china sources I'm not comfortable ordering more and don't wanna risk running out too soon. so I'll stay at 10mg for a while more.
Ghoul
Member
TLDR:
Conventional dieting creates an excessive metabolic slowdown. Far overshooting the reduction in energy needs of less body mass, along with intense hunger, as a way to force you back to the "set point" of body mass your biology seeks to keep you at.
Sema and Tirz slow metabolism down to the point expected to meet the needs of less body mass. without any "extra" reduction in resting energy expenditure. . GLP, on a dose dependent basis, essentially moves the "set point" of body mass lower, avoiding the starvation response above,
Reta slows metabolism less than Sema and Tirz. At larger doses metabolism is likely higher than you'd expect for a given body mass.
Ghoul
Member
They're used interchangeably in these mechanistic discussions. It's not exclusively one or the other.
Both fat and lean mass produce hormones that cumulatively "tell" the appetite regulation system what the caloric needs are for your current body composition and size.
BrunoES
Member
So, basically, people experience less metabolic adaptation with Tirz and Sema, and even less with Reta, compared to traditional dieting without GLPs?
yes, probably because they lower your weight "setpoint". So you don't get the lethargy and possible downregulatio of thyroid hormones/steroidogenesis you'd get when below your natural bodyweight
Ghoul
Member
Yes. Sema and Tirz essentially set a "normal" metabolic rate for the needs of your body size.
Reta sets it higher than your needs.
Regular dieting sets it far below, in part to weaken your conscious "willpower" and ability to resist the unconscious instinct to eat.
Ghoul
Member
The idea is of metabolism can be prevented from slowing as much as it would on a regular diet, you'll burn more calories just existing, which contributes to faster weight loss (and more energy than if metabolism was slowed more).
Reta was designed as an attempt to speed up metabolism and provide more weight loss faster than older GLPs.
I'm sure you've heard of people commenting on someone being thin due to a fast metabolism.
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