MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Ghoul
Member
Have you checked thyroid function? That’s the metabolic master control, and when levels drop, as they often do in a caloric deficit, with seasonality, age, etc, you become more cold sensitive. Conversely when levels are high, you’re sweating in a snowstorm and it’s a battle to eat enough calories to maintain muscle.
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Ghoul
Member
There seems to be a point where receptors are saturated, and higher doses no longer have an effect, FYI, so there’s a ceiling.
But GLP receptor density seems to vary tremendously between individuals (though men generally have higher density) so where that ceiling is who knows.
One theory is that proportion of GLP receptors agonized determine amount of weight loss, which may be why women typically respond to very low doses, and men often require much higher doses for the same amount of loss.
Infernalmango
Member
Pretty shortly after increasing to 8mg myself I started getting orthostatic hypotension and just a general unwell feeling. Had to increase sodium/electrolytes aggressively to get them to subside. Still not 100% feeling great yet, but better than I was. Getting bloods Monday to see if anything looks weird as well.
I'm up now and don't feel as bad. Saturday is my off day so we'll see how much I can eat today. I'll give the electrolytes a go.
How did you get insurance to cover this?
Ghoul
Member
27 BMI and diagnosed with high blood pressure. Also had high cholesterol, but either one would qualify you.
Basically, most insurance companies in the US require:
Minimum 27 BMI and one other condition:
-High blood pressure
-High cholesterol
-Sleep apnea
(Even if these are being treated with other meds)
Or
Minimum 30 BMI even with no other conditions
To qualify for Wegovy (Sema) or Zepbound (Tirz).
and once on, you don’t lose coverage after dropping below the BMI. It’s considered a lifetime maintenance medication.
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I was on 4. Started at 2 for 1 month, 4, for 1 month. Maybe this was too fast.
koast123
Member
Im using 15mg Tirz as well in my lean bulk mesocycle. Ill change to 12mg Reta, ill tell you hows going, im interested in the superior hunger supression of Tirz in a cut and the metabolic and Gh sinergy in a bulk... At leat theorically.
Ghoul
Member
All the glucagon magic happens at the higher doses that use in test trials that so few seem ti get to here.
If Reta’s working well, and you’re not turning into a diabetic from glucagon boosting blood glucose levels and GH increasing Insulin resistance I wouldn’t change anything. With Tirz you could lose a few hundred calories glucagon is burning “for free”, and with Tirz you’d either have to eat less or do more cardio to make sure you don’t slowly start gaining. Unless you’re in a deficit now and want to stop losing. Then a switch to Tirz for maintenance may make sense. Better insulin sensitivity to avoid any issues from GH, and much easier on your wallet too.
Anyone has experience adding Cagri on top of Tirz?
tried 12.5mg Tirz but seems like 10mg is a upper celing for me and any higher does nothing more.
Got some Cagri on the way to try because of junk food cravings. every time I start eating it's like I can't stop unless I'm physically sick. even with plenty of protein and fiber
tried 12.5mg Tirz but seems like 10mg is a upper celing for me and any higher does nothing more.
Got some Cagri on the way to try because of junk food cravings. every time I start eating it's like I can't stop unless I'm physically sick. even with plenty of protein and fiber
Also what is the general consensus about once a week dosing vs mutliple doses?
Many online "influencers" make a case for microdosing, like if you have a a million GIP receptors and inject 3million particles of Tirz all once the rest is gettinf "wasted", so splitting the dose would be more effective?
Not my words, just what I heard, asking if it makes any sense and if so should I switch to like 3mg EOD instead of 10mg weekly?
like could that result in any tangible difference in appetite suppression?
I did notice massive diminishing returns going from 5mg to 10mg, and 12.5 did nothing more than 10. so wonder if the thing of the receptors being fully saturated is actually valid
fit2beking
New Member
I have added cagri to tirz and it seemed to cut out food noise at first. After about 6 weeks in I decided to cut it because after about 2 days after injection each week the food noise was back. Grant it this was used while blasting and I can generally eat past tirz at 15 and 20mg doses. I have since added in sema at .25mg and that has a much stronger impact on food noise and I am not able to eat past the tirz and sema combo. Cagri hits a different receptor than sema and tirz. It doesn’t seem as strong to me in terms of dialing down food noise or impact on how much I can eat as compared to sema. Adding that small bit of sema on top of tirz is yielding better results in terms of satiety and food noise for me. I can be mid meal and have to stop because I’m full. If you force feed past sema you will pay dearly. It’s really the less forgiving of the GLP’s. I do know people who had had good success with adding cagri though. Good luck with it.
Wow, ever since I started Reta, I’ve been craving sweets like crazy. I’m keeping it under control, but last night I actually woke up in the middle of the night wanting sugar so bad… and since I don’t keep any at home, I had to settle for eating my girlfriend instead. When I was on Tirz, sugar didn’t even cross my mind. This stuff hits different!
Jesintn
Member
View: https://youtu.be/6BwF5kMggCo?si=9IrYbP279zoclaG8
Start around 35-37 mins in where Chad talks about how glps may cause competing bodybuilders dissension
And how sema totally stops food moving. Im guessing this is dose dependent and anything orally taking can stay in there longer
There’s still much thats not known in competition preparation and glps. If a competitor can not handle them coming into a competition, or unsure until further facts are found out, then probably best to not dose too high , and best to cut them out a couple weeks out until more is known
SnowyMiami
Member
This years Olympia was the first where everyone was on GLPs and it was the most pathetic.
Liter O' Test
Member
it gets more pathetic every year because no one is taking DNP, Meth and deadly doses of diuretics
Liter O' Test
Member
two weeks of 6mg tirz,
now i just finished my second week of 7mg tirz
going to have to go back to 6mg,
i think im just tossing and turning at night with food in my gut.
I could try to eat more cals in the morning but idk
now i just finished my second week of 7mg tirz
going to have to go back to 6mg,
i think im just tossing and turning at night with food in my gut.
I could try to eat more cals in the morning but idk
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