GIP is not your friend. And why Tirzepatide is superior to Retatrutide

[trev55]

There isn't any good long term human data on these GLP-1/GIP agonist drugs, most of what we know comes from studies on rodents so I'm going to post my thoughts about why some of these drugs may be doing more harm than good, especially in lean, insulin sensitive individuals.
I'll break it into a few parts, and why Tirz is probably much safer and better over the long term than Reta.

1. GIP is not your friend.
GIP isn’t being discussed nearly as much as GLP-1 in fitness contexts, even though many of the newest incretin drugs now deliberately agonize the GIP receptor alongside GLP-1. I want to lay out why I’m not convinced this is automatically a good thing for those who aren't fat as fuck.

Before the current popularity of dual- and multi-agonist drugs — like tirzepatide and retatrutide — GIP was originally dubbed in the literature as the obesity hormone. GIP's normal physiological role after eating is to promote fat storage in adipose tissue.

In white adipose tissue, GIP signaling tends to suppress lipolysis and promote lipid storage, causing increases in white adipose fat mass under caloric excess.

There is evidence in rats that GIP shifts insulin sensitivity in a tissue specific way, reducing insulin sensitivity in muscle, liver and brown adipose tissue, and increasing insulin sensitivity in WAT.

In rodents, CNS GIP signalling has been linked to increased neuroinflammatory signalling, and reduced leptin responsiveness in appetite-regulating centers, so it is eventually de-sensitizing you to the master satiety hormone, a condition seen in obesity.

Finally GIP is described as supporting pancreatic beta-cell proliferation and survival, which is one of the reasons it’s viewed positively in diabetes treatment. However, there is also evidence that chronic overstimulation of the GIP pathway can lead to receptor desensitization and reduced effectiveness over time.

The point is that GIP's role is not a fat loss support hormone, it is a fat storage hormone which makes me question whether strong GIP agonism is helpful or actually harmful for people without existing obesity & insulin resistance.

 

[Country Club Hero]

I’ve used all 3 and determined a while back that I liked Tirz the best. Doesn’t make me feel trashy like Sema but provides way more appetite suppression than Reta. I guess I go by feelz with most things and am usually proven right after science comes out. And I’d be considered fairly lean before using any of them.

 

[gobig2]

so which is best if trying to get your fasted blood glucose down and shed some belly fat? Have horrible sugar cravings at night. A1C is fine but blood glucose always running in the low 100's.

 

[BabaJagga]

i think reta is overhyped by plenty of internet people trying to make profit of selling it. they buy it from china for cheap price, than make videos about how amazing it is, its the best thing in the world etc etc, then sell it with huge profit. they can do that cause its still grey zone. probably cant happen with tirz.

after that internet does its thing and people "parrots" same stuff over and over
"add reta for health"
"add reta to test & gh thats god stack"
"reta this reta that"
meanwhile most of them dont understand these drugs at all and all their knowleage comes from 10 second videos on social media

i think tirz is fine and its very effective. im even happy that people switched to reta mostly and tirz is even cheaper.
sema would work as well but i went for tirz cause it should have less sides. and i have 0
issues.

 

[Dohtem22]

So, what if you have lost a bunch of weight on Tirz and are now in a maintenance phase? Would you stick with high dose tirz or switch to reta?

Congrats on the weight loss… during that time did you learn more about diet and fix your relationship with food? Or are you just going to rely on the drug to “maintain” the rest of your life?

Everyone- “THE OTHER HEALTH BENEFITS THOUGH! “

 

[BabaJagga]

Congrats on the weight loss… during that time did you learn more about diet and fix your relationship with food? Or are you just going to rely on the drug to “maintain” the rest of your life?

Everyone- “THE OTHER HEALTH BENEFITS THOUGH! “

blood sugar control with gh is real.
ive found that slow tappering down works great. agter that just use gear amd bulk

 

[Sampei]

I think you all are missing a massive point on why reta is considered the favourite for most of bodybuilders. Yes you read it correctly: BODYBUILDERS.

not fat ppl, not ex obese with hunger issues that can't manage appetite on a cut for many reasons or whatever other categories you wanna fit in.

BODYBUILDERS aka ppl that when there was no reta sema tirz were able and are still able to diet down to low single digit bodyfat with mostly sheer willpower.

Now if we assume that we are in a bodybuilding forum (aahahahahahaha) and we are all practicing mostly this discipline why is reta the superior substance for a bodybuilder?

Is it that hard to understand?
LOW APPETITE SUPPRESION, exactly you got that perfectly right. A bodybuilder doesn't want and need strong appetite suppression, he wants all the other benefit of the glp-1 family. Higher insulin sensitivity, reduced systemic inflammation, better lipids, better BP etc.
Why? Because it fuckings let them use more GH first of all and optimize every other process BUT it lets them bulk while they maintain better insulin sensitivity and it lets them cut without the massive struggle of crazy hunger.

A REAL bodybuilder will laugh in the face of ppl saying oh but reta doesn't suppress as much as tirz I still want to eat here and there.

Brother these ppl starve themselves down to 5% BF while still training and working the life, do you really think they have issue managing a little less appetit suppression vs when they were doing the same without any appetite suppression at all?

One more thing, tirz gives to many ppl, fatigue, acid reflux, very slow gastric emptiness, a lot of hunger suppression, with amazing insulin sensitivity that... You can't use for shit because you can't slam food on it.

Yes this is the average experience of th average user so ON AVERAGE for a bodybuilder reta is superior.

For any other person it is a matter of choices.

 

[DigD]

There isn't any good long term human data on these GLP-1/GIP agonist drugs, most of what we know comes from studies on rodents so I'm going to post my thoughts about why some of these drugs may be doing more harm than good, especially in lean, insulin sensitive individuals.
I'll break it into a few parts, and why Tirz is probably much safer and better over the long term than Reta.

1. GIP is not your friend.
GIP isn’t being discussed nearly as much as GLP-1 in fitness contexts, even though many of the newest incretin drugs now deliberately agonize the GIP receptor alongside GLP-1. I want to lay out why I’m not convinced this is automatically a good thing for those who aren't fat as fuck.

Before the current popularity of dual- and multi-agonist drugs — like tirzepatide and retatrutide — GIP was originally dubbed in the literature as the obesity hormone. GIP's normal physiological role after eating is to promote fat storage in adipose tissue.

In white adipose tissue, GIP signaling tends to suppress lipolysis and promote lipid storage, causing increases in white adipose fat mass under caloric excess.

There is evidence in rats that GIP shifts insulin sensitivity in a tissue specific way, reducing insulin sensitivity in muscle, liver and brown adipose tissue, and increasing insulin sensitivity in WAT.

In rodents, CNS GIP signalling has been linked to increased neuroinflammatory signalling, and reduced leptin responsiveness in appetite-regulating centers, so it is eventually de-sensitizing you to the master satiety hormone, a condition seen in obesity.

Finally GIP is described as supporting pancreatic beta-cell proliferation and survival, which is one of the reasons it’s viewed positively in diabetes treatment. However, there is also evidence that chronic overstimulation of the GIP pathway can lead to receptor desensitization and reduced effectiveness over time.

The point is that GIP's role is not a fat loss support hormone, it is a fat storage hormone which makes me question whether strong GIP agonism is helpful or actually harmful for people without existing obesity & insulin resistance.

AM I allowed to expose lab selling fake reta in here?