GLP-1 peptide with best insulin sensitivity?

[Delux]

I'm curious if anyone knows definitively which GLP-1 drug (semaglutide, tirzepatide, or retatrutide) has the biggest effect on insulin sensitivity? I'm guessing its semaglutide as that was its primary use for a long time, but I wasn't sure if tirzepatides effect on GIP or retatrutides effect on glucagon make either of those even more effective at insulin sensitivity?

 

[sushak]

I'm curious if anyone knows definitively which GLP-1 drug (semaglutide, tirzepatide, or retatrutide) has the biggest effect on insulin sensitivity? I'm guessing its semaglutide as that was its primary use for a long time, but I wasn't sure if tirzepatides effect on GIP or retatrutides effect on glucagon make either of those even more effective at insulin sensitivity?

This might help, might as well just use tirz when looking at hb1ac

 

[Middus]

I'm curious if anyone knows definitively which GLP-1 drug (semaglutide, tirzepatide, or retatrutide) has the biggest effect on insulin sensitivity? I'm guessing its semaglutide as that was its primary use for a long time, but I wasn't sure if tirzepatides effect on GIP or retatrutides effect on glucagon make either of those even more effective at insulin sensitivity?

The effectiveness and value of tirzepatide for type 2 diabetes mellitus: A Summary from the Institute for Clinical and Economic Review’s New England Comparative Effectiveness Public Advisory Council - PMC

pmc.ncbi.nlm.nih.gov

Just go for Tirz. You won't find definitive studies for Reta, and Tirz is easier on the wallet.

 

[UncleBuns]

View attachment 309923

The effectiveness and value of tirzepatide for type 2 diabetes mellitus: A Summary from the Institute for Clinical and Economic Review’s New England Comparative Effectiveness Public Advisory Council - PMC

pmc.ncbi.nlm.nih.gov

Just go for Tirz. You won't find definitive studies for Reta, and Tirz is easier on the wallet.

The odd thing about that study is that 15mg tirz is roughly equivalent to 2.4mg sema. So, they compared Max dose tirz to ~40% Max dose sema. That doesn't seem like a fair comparison. Those result numbers don't mean much.

 

[Type-IIx]

I'm curious if anyone knows definitively which GLP-1 drug (semaglutide, tirzepatide, or retatrutide) has the biggest effect on insulin sensitivity? I'm guessing its semaglutide as that was its primary use for a long time, but I wasn't sure if tirzepatides effect on GIP or retatrutides effect on glucagon make either of those even more effective at insulin sensitivity?

With respect to insulin sensitizing effects, retatrutide > tirzepatide > semaglutide. Not so with respect to effects on fat loss, however.

 

[Middus]

With respect to insulin sensitizing effects, retatrutide > tirzepatide > semaglutide. Not so with respect to effects on fat loss, however.

There is a study in mice that said Reta didn't outperform tirz in glucose control for diabetic mice

 

[Middus]

The odd thing about that study is that 15mg tirz is roughly equivalent to 2.4mg sema. So, they compared Max dose tirz to ~40% Max dose sema. That doesn't seem like a fair comparison. Those result numbers don't mean much.

The context when this study was done was 'available data'. They did a direct comparison of 5, 10 and 15mg Tirz vs Semaglutide 1mg as Sema 1mg was the established diabetes control regimen (in 2021). The same group also carried out another study they released latter that same year, comparing sema 1mg to sema 2mg.
They letter released yet another article showing there was no difference in A1c control between 5mg vs 2mg sema (indirect comparison)
And at higher doses, Tirz did better than 2mg sema.
Now that 7.2 sema has been trialed for safety and results are being awaited, they will surely get funding for yet another comparison.

 

[Type-IIx]

There is a study in mice that said Reta didn't outperform tirz in glucose control for diabetic mice

Oh, no shit??? Fuck, I must have just been totally off base having formed my view on the basis of the totality of the literature, bolstered as well by empirical data working with clients that basically all use GLP-1s, or combined incretin drugs.

 

[Middus]

Oh, no shit??? Fuck, I must have just been totally off base having formed my view on the basis of the totality of the literature, bolstered as well by empirical data working with clients that basically all use GLP-1s, or combined incretin drugs.

This could have been politely stated, instead you chose to take a study finding as a direct attack on your anecdotal experience(s).
As it happens I did find a litt review which i didn't post because I didn't see the benefit. I'm just going to post it anyway

https://www.sciencedirect.com/science/article/pii/S0196978124000020/pdfft?md5=05fca609d6a50eb0b28c9ea65fd7d0fa&pid=1-s2.0-S0196978124000020-main.pdf

 

[readalot]