GLP difference

[Here2Learn]

TLDR:
No GLP+ working out +tracking food=no WL 1 year
GLP+low calories=very small WL Oct 1- Oct 15 .8lb loss
GLP+more food+weight training=fast WL Oct 15-30 4.8lb loss


I used to workout all the time, then went undiagnosed with scarlet fever for a couple of years and almost died. It’s been 24 years and I still don’t feel like my body has fully recovered.

Couple years ago I got back into weight training and tracking all of my food. I felt good but the scale would go up and down 5lbs and I never lost weight. My inflammation was so high and never got relief. Stuck with it for a year and then we had a big cross country move and I didn’t get things going again.

Now I started taking Sema the end of April which really helped my inflammation so my joint pain was a lot better. I was exhausted on it all the time though, non function barely getting through work. Scale moved but very slowly. Switch to Tirz and felt a lot better so I started lifting weights again, tracking food and all just the way I had before. On just Tirz the scale moved slowly. Adding in the workouts and the extra food the scale has really been moving.

I’ve enjoyed learning and tracking my data points. I have some healing peptides in the mail and hope to get some more long term things addressed.

 

[Ghoul]

What protocol on Tirz?

 

[Here2Learn]

What protocol on Tirz?

I’m only up to 4mg right now. Started 09/20 on 2.5mg

 

[Here2Learn]

I’m only up to 4mg right now. Started 09/20 on 2.5mg

Also, had been dosing Reta .5mg for boost to energy.

Have no real appetite suppression or GI issues.

 

[Ghoul]

Also, had been dosing Reta .5mg for boost to energy.

Have no real appetite suppression or GI issues.

When you look at the Tirz trials, as weekly doses are titrated up, 2.5-5-7.5-10-12.5-15, the number of "non responders" shrinks. There's a big drop off around 7.5, and by 15mg there are nearly no non responders, less than 1%.

The appetite suppression effects appear dependent on the total proportion of GLP receptors agonized. Everyone has a different amount, men having more dense concentrations, and larger body mass typically having more. But much of this is also based on genetics.

So don't lose heart over your non response. 7.5 would be the next stop after 5 on the pharma protocol. Since 4 is ineffective, I'd go straight to 7.5. There's no risk of getting severe sides with this jump, Tirz is so much more mild than Sema. If you still feel nothing after TWO weeks, two doses, go to 10mg. It's almost certain you'll find that dose effective.. After plateauing, to lose more, titrate to 12.5, then 15 if necessary.

I'd avoid stacking, try to stick to once a week dosing, and only after failing to respond at 15mg would I change the plan.

 

[Here2Learn]

When you look at the Tirz trials, as weekly doses are titrated up, 2.5-5-7.5-10-12.5-15, the number of "non responders" shrinks. There's a big drop off around 7.5, and by 15mg there are nearly no non responders, less than 1%.

The appetite suppression effects appear dependent on the total proportion of GLP receptors agonized. Everyone has a different amount, men having more dense concentrations, and larger body mass typically having more. But much of this is also based on genetics.

So don't lose heart over your non response. 7.5 would be the next stop after 5 on the pharma protocol. Since 4 is ineffective, I'd go straight to 7.5. There's no risk of getting severe sides with this jump, Tirz is so much more mild than Sema. If you still feel nothing after TWO weeks, two doses, go to 10mg. It's almost certain you'll find that dose effective.. After plateauing, to lose more, titrate to 12.5, then 15 if necessary.

I'd avoid stacking, try to stick to once a week dosing, and only after failing to respond at 15mg would I change the plan.

I don’t feel like I need to go up right now as I am losing. Yea I don’t get appetite suppression but honestly that isn’t a huge deal for me. Seems like it is working at 4mg being the scale is moving. I personally would prefer to keep my hunger to build my habits on normal living.

 

[karmasutras]

I got up to 7.5 before I couldn't stand eating anymore

 

[canes]

10mg was the sweetspot for me. Split between two dosages

 

[FoulPlay]

Just started 10mgs of prescription Tirz last week. I’ve had 0 appetite suppression the entire time, HOWEVER, without changing my diet or exercise regimen I have lost 34 lbs since first getting prescribed Tirz inJune (278lbs-244lbs.) So the medicine is clearly doing something but I still have hunger pains and think about food all day. I’m also eating between 3100-3200 calories a day. I track everything that goes in my mouth and weigh/portion all my food right now. I lift at the gym 6 days a week, go to physical therapy 3 days a week and do no cardio currently. Tirz clearly works. I just wish I got the appetite suppression everyone else gets.

 

[Ghoul]

Just started 10mgs of prescription Tirz last week. I’ve had 0 appetite suppression the entire time, HOWEVER, without changing my diet or exercise regimen I have lost 34 lbs since first getting prescribed Tirz inJune (278lbs-244lbs.) So the medicine is clearly doing something but I still have hunger pains and think about food all day. I’m also eating between 3100-3200 calories a day. I track everything that goes in my mouth and weigh/portion all my food right now. I lift at the gym 6 days a week, go to physical therapy 3 days a week and do no cardio currently. Tirz clearly works. I just wish I got the appetite suppression everyone else gets.

Stay the course, The "one size fits all" doses are, unfortunately a crude way of prescribing these. Effectiveness is hypothesized to be determined by the total proportion of GLP receptors hit, and since being male, and large, means you have far more than a 5' woman being given the same dose, it can take a while to get to the dose where you finally "feel" it.

 

[Here2Learn]

I personally feel like it is working out that tips the balance on GLP’s. There are definitely those who get instant results without it but those not seeing movement on the scale it seems to really change with the added movement. Not even so much the calories in making the difference.

Just started 10mgs of prescription Tirz last week. I’ve had 0 appetite suppression the entire time, HOWEVER, without changing my diet or exercise regimen I have lost 34 lbs since first getting prescribed Tirz inJune (278lbs-244lbs.) So the medicine is clearly doing something but I still have hunger pains and think about food all day. I’m also eating between 3100-3200 calories a day. I track everything that goes in my mouth and weigh/portion all my food right now. I lift at the gym 6 days a week, go to physical therapy 3 days a week and do no cardio currently. Tirz clearly works. I just wish I got the appetite suppression everyone else gets.

 

[FoulPlay]

Stay the course, The "one size fits all" doses are, unfortunately a crude way of prescribing these. Effectiveness is hypothesized to be determined by the total proportion of GLP receptors hit, and since being male, and large, means you have far more than a 5' woman being given the same dose, it can take a while to get to the dose where you finally "feel" it.

Yeah that’s my plan. Like I said, it’s working so I’m still going to ride it out. Especially since my insurance completely covers it. So I’m paying nothing out of pocket.

 

[FoulPlay]

I tore my pec back in May, so I’m just finally starting to really train hard again. I agree, the harder I train, the more I notice the difference. Not even so much the scale but more so the mirror. I don’t mind being 240lbs if I was around 12-15% body fat. But being probably 25-30% at 240 is too much. But I’ve dropped 1 pants size from June-Sep and 2 more since October. But weight only went down about 9 lbs since October. I’m loving it.

I personally feel like it is working out that tips the balance on GLP’s. There are definitely those who get instant results without it but those not seeing movement on the scale it seems to really change with the added movement. Not even so much the calories in making the difference

 

[Ghoul]

I personally feel like it is working out that tips the balance on GLP’s. There are definitely those who get instant results without it but those not seeing movement on the scale it seems to really change with the added movement. Not even so much the calories in making the difference.

Technically all the insurance companies require an exercise and diet plan to be in place for coverage. Seems like every doc just lies about that.

Pro Tip:

I took advantage of that requirement to get Telehealth consults with a nurse practitioner dietician paid by insurance.

She's been immensely helpful with tips on how to maximize health by tweaking my diet. It's not for weight loss, just a pro.'s tips on how to use food to achieve my health goals for my particular circumstances. She's a consultant for sports teams, and I get her $275/session consults at no charge.

 

[FoulPlay]

Technically all the insurance companies require an exercise and diet plan to be in place for coverage. Seems like every doc just lies about that.

Pro Tip:

I took advantage of that requirement to get Telehealth consults with a nurse practitioner dietician paid by insurance.

She's been on immensely helpful with tips on how to maximize health by tweaking my diet. It's not for weight loss, just a pro.'s tips on how to use food to achieve my health goals for my particular circumstances. She's a consultant for sports teams, and I get her services at no charge.

I did a similar thing. I go to an in person dietician though. Insurance covers everything. They asked me if I had a diet regime and an exercise plan. I did so I was honest but there was no checking in on it. My dietician is into bodybuilding so he’s definitely the guy for me. I have no desire to ever compete or look like the pros, but still want to be the biggest 8u baseball coach you know. He tried being my plug for AAS lol. Before seeing him though, I never realized how little protein I was eating. I typically didn’t even get 120g a day. But in my head I was easily over 200g. I was way wrong.

 

[Ghoul]

I did a similar thing. I go to an in person dietician though. Insurance covers everything. They asked me if I had a diet regime and an exercise plan. I did so I was honest but there was no checking in on it. My dietician is into bodybuilding so he’s definitely the guy for me. I have no desire to ever compete or look like the pros, but still want to be the biggest 8u baseball coach you know. He tried being my plug for AAS lol. Before seeing him though, I never realized how little protein I was eating. I typically didn’t even get 120g a day. But in my head I was easily over 200g. I was way wrong.

I have my trainer talk to her for some good fitness goal synergy