Hexarelin vs ipamorelin vs tesamorelin...

[Nidus]

IIRC... the body produces close to "2iU" and the secretegogue(s) add another "1-1.5iU." And see below...

Wasn't it one of Type-II's pieces, or can't remember where I read, but... combining is possible, but only when its low dosed hGH (about 1-2iU). Above 2iU and the hGH cancels out the secretagogue(s). I'll have to find that, my apologies for not posting the data at this time.

Below, are some of Type-II's posts regarding "interference effect" between r-hGH and secretagogues. I'm still—when time permits—reading his book... it's likely covered there as well.

So they key-takeaway here is, dont spend money on GH and 4x GH peptide blends. Just buy a good chunk of GH, run 3-4iu ed right before bed.

Wouldn't turn this into rocket science for OP, keeping it simple and straightforward.

 

[bigMoJo]

So they key-takeaway here is, dont spend money on GH and 4x GH peptide blends. Just buy a good chunk of GH, run 3-4iu ed right before bed.

Wouldn't turn this into rocket science for OP, keeping it simple and straightforward.

I agree with you here. As a practical matter, it makes sense to run r-hGH.

But, we live in a world where you can have a latte on the sidewalk in the morning, lunch at the sushi bar, and hit the strip club at night. Or, however way you want to put together your day.

If OP sees benefits to this approach after gathering the accurate data... why not?

Nonetheless, you and I both know the "power of the dark side" and we must obey.

 

[dropout]

Yes, peptides and HGH can be taken together, but you should consult your local health authority for more information.
Studies on peptides and HGH

• A study found that combining growth hormone-releasing hormone (GHRH) and hexapeptide GH-releasing peptide-6 (GHRP-6) can cause a large increase in plasma GH levels.
• Another study found that coadministration of GH-releasing peptide-2 (GHRP-2), TRH, and GnRH reactivated the GH, TSH, and LH axes in prolonged critically ill men.
• A study found that hexarelin plus GHRH are synergistic and have potent GH-releasing activity.
• A study found that pretreatment with BPC 157 can enhance the effect of growth hormone in a dose- and time-dependent manner

Did you even read your ChatGPT generated answer before posting it here? None of these bullet points are about taking exogenous HGH along with HGH stimulating peptides (GHRH/GHRP).

 

[Nidus]

I agree with you here. As a practical matter, it makes sense to run r-hGH.

But, we live in a world where you can have a latte on the sidewalk in the morning, lunch at the sushi bar, and hit the strip club at night. Or, however way you want to put together your day.

If OP sees benefits to this approach after gathering the accurate data... why not?

Nonetheless, you and I both know the "power of the dark side" and we must obey.

Trying to still educate people, if they want to burn their money sure but at least educate yourself.

Did you even read your ChatGPT generated answer before posting it here? None of these bullet points are about taking exogenous HGH along with HGH stimulating peptides (GHRH/GHRP).

I mean, the fact that his Clinic even prescribes those 4-5 combined is very questionable.

 

[UncleBuns]

So they key-takeaway here is, dont spend money on GH and 4x GH peptide blends. Just buy a good chunk of GH, run 3-4iu ed right before bed.

Wouldn't turn this into rocket science for OP, keeping it simple and straightforward.

No, It depends on your goals. For many it is ideal to just use GH, but some people get benefit from using peptides as well. A missing piece in the discussion is that once you get about 16 hours away from the administration of GH peptides are not as much inhibited and can produce more endogenous GH. The benefits they can have on sleep are also very valuable for some people. It really depends on the individual's goals.

 

[UncleBuns]

Either way, it makes sense to only run. Even when taking GH and the GH peptides apart, still takes 24h to fully restore the owns GH production as far as i know. Plus when by the time you have 3-4iu GH in the system i could imagine that there is a decent level of somatostatin (the counter part of GH from the body to down regulate GH production) that your 4x GH blends together wont do anything.

Also GH Peptides require you to be fasted otherwise their effects are little to none, eating and causing insulin&glucose spikes downregulate GH production on top afaik.

To achieve a great boost you would need to run 400-500mcg of each GH peptide and that just for what, 1iu more? 1.5-2iu?

Just go with 3-4iu GH.

It does not require 24 hours. About 16 hours. You seem to be solely focused on mass building for bodybuilding purposes. In that case, yes, just use more GH. There are other use cases where the peptides can be helpful though. You are looking at this from one mindset and 1 goal.

 

[Type-IIx]

IIRC... the body produces close to "2iU" and the secretegogue(s) add another "1-1.5iU." And see below...

Wasn't it one of Type-II's pieces, or can't remember where I read, but... combining is possible, but only when its low dosed hGH (about 1-2iU). Above 2iU and the hGH cancels out the secretagogue(s). I'll have to find that, my apologies for not posting the data at this time.

Below, are some of Type-II's posts regarding "interference effect" between r-hGH and secretagogues. I'm still—when time permits—reading his book... it's likely covered there as well.

I’m going to announce a symposium I’m doing next Saturday about RhGH vs. GH Secretagogues: When, How, Why; worked examples for men and women who really get a lot more out of Secretagogues than GH, or men!

 

[AlexDavis43]

I mean, the fact that his Clinic even prescribes those 4-5 combined is very questionable.

Good call.

Please explain, @fw190jd

 

[Sampei]

It does not require 24 hours. About 16 hours. You seem to be solely focused on mass building for bodybuilding purposes. In that case, yes, just use more GH. There are other use cases where the peptides can be helpful though. You are looking at this from one mindset and 1 goal.

If I'm not mistaken studies shows suppression well over 24hr after one HGH injection your have data to prove the opposite? I would love to read it

 

[AlexDavis43]

If I'm not mistaken studies shows suppression well over 24hr after one HGH injection your have data to prove the opposite? I would love to read it

I take hGH 5 IU twice a day. Problem solved.

 

[UncleBuns]

If I'm not mistaken studies shows suppression well over 24hr after one HGH injection your have data to prove the opposite? I would love to read it

It is not an on/off switch. Obviously suppression is strongest closer to the injection and as time goes on, the amount of suppression decreases. The further away you get the less suppression there is in peptides are able to break through the suppression to different degrees depending on how far away from the injection you are.

References I can get are out of Bolus book. #70 and 73. Don't have time right now but maybe if I do I will try to find them

So long as the Ipamorelin & CJC-129... DAC/without is being used primarily for sleep because it is the drug that aids in your sleep better than anything else, then it makes good sense.

By 16 h there is often (significant) escape from suppression of pulsatile endogenous GH secretion, with some dose dependency (i.e., higher rhGH doses suppress GH secretion more fully than lower) but usually not restoration to full GH secretion. The time-course respect to restoration of endogenous GH secretion post-rGH bolus differs between (inter-) and within (intra-) individuals on the basis of factors like injection depth and dose. The mean for this in non-GHD subjects is usually basically 1 day (~ 22 h mean value).

You'll likely get a small-moderate GH secretion in the nighttime by doing this, and the same effect on sleep quality that you get from the combined GH secretagogues.

 

[fw190jd]

I’m going to announce a symposium I’m doing next Saturday about RhGH vs. GH Secretagogues: When, How, Why; worked examples for men and women who really get a lot more out of Secretagogues than GH, or men!

I just found your podcast yesterday and started listening to it. I was listening to the reference on sleep, my doctor has me on Ambien cuz I can't sleep at night despite all this other stuff that I'm doing to stay healthy, weight training, peptides HGH Etc.
Could never get Beyond 5 and 1/2 to 6 hours not even great quality sleep so for the first time after listening to your podcast in 4 years I went to bed with no ambient at all last night and took a simple 3 mg pill of melatonin. I had the best night's sleep that I've had in years I hope it will continue and I'm looking forward to your next Symposium on HGH

 

[Type-IIx]

I just found your podcast yesterday and started listening to it. I was listening to the reference on sleep, my doctor has me on Ambien cuz I can't sleep at night despite all this other stuff that I'm doing to stay healthy, weight training, peptides HGH Etc.
Could never get Beyond 5 and 1/2 to 6 hours not even great quality sleep so for the first time after listening to your podcast in 4 years I went to bed with no ambient at all last night and took a simple 3 mg pill of melatonin. I had the best night's sleep that I've had in years I hope it will continue and I'm looking forward to your next Symposium on HGH

Glad to hear it brother. I'll make an announcement tomorrow about the Symposium Saturday, Mar 22