MESO-Rx
Anabolic Steroids
HGH, IgF and Metformin
- Thread starter Bammdk
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MA11
Member
Thread 'hGH + Metformin: A Good Thing (Metformin does not lower, but rather increases IGF-1)' hGH + Metformin: A Good Thing (Metformin does not lower, but rather increases IGF-1)
Are er sure? Everybody else is saying the oppositite
AlexDavis43
Member
Seems like you got your answer.
I dont. I asked in the first place, because I like to hear different View. Lots of clever people here, so you Can learn new things.
29trt
Well-known Member
The answer is nobody actually knows if metformin affects AAS users in regards to hypertrophy,it may lower or increase IGF but so what? There are guys with 250 igf that are 250lbs lean and guys around here with 600igf at 180lbs wet....
Fact is professional level bodybuilders use metformin and don't worry ... So if metformin keeps your BG in check on high dose GH and food than I would use it and see the results....
If it bloats you like shit and you can't eat than tou have your answer ....
Like all drugs the effects and side effects are very individual and you have to try it out and monitor
All the guys quoting studies are just using them to help make decisions instead of relaying on experience sometimes the answer is the same sometimes not... Depends on how close the study was to reality...
MA11
Member
I think there's no much risk in trying metformin for yourself. I myself will try it for (potential) insulin resistance from HGH. I do not take any AAS.
Experience from tiger users vary a lot.
Thread 'Personal Experiences with Metformin Use and its Training Adaptation Effects' Personal Experiences with Metformin Use and its Training Adaptation Effects
Experience from tiger users vary a lot.
Thread 'Personal Experiences with Metformin Use and its Training Adaptation Effects' Personal Experiences with Metformin Use and its Training Adaptation Effects
ZyzzReincarnate
Member
Metformin lowers IGF-1 significantly
No it doesn't. Been taking it for years and has never lowered my IGF-1 while taking AAS and GH. Most of the studies showing it lowered IGF-1 were in people that didn't weight train and obviously didn't use AAS.
ZyzzReincarnate
Member
Tell that to vigorous steve. I hope he is wrong here but i dont think he is
MA11
Member
Dear mother of God.
why don't you do your own blood? My IGF-1 has never been lower on Metformin... Of course I take AS + GH
ZyzzReincarnate
Member
Because that would only be one point of data.
MyNameIsJeff
Well-known Member
See below (yes, the authors use the wrong inequality sign, but it is clear from their discussion that the '18>' row is supposed to represent the age>18 group. And the minus sign is missing from the lower bound, very sloppy).
Last edited:
iris
Well-known Member
MA11
Member
And the only data point that counts for you.
ZyzzReincarnate
Member
Well, there are a lot of other variables at play. I'm not saying it would be useless though.
UncleBuns
Well-known Member
What evidence do you have to back this claim up besides Vigorous Steve? Using Vigorous Steve as a reference is like submitting a research paper referencing Wikipedia aka not worth much.
ZyzzReincarnate
Member
Well, I've also asked chatGPT this question in the past and it confirmed this as well. I'll ask it to provide sources this time as I know ChatGPT isnt exactly the gold standard.
Metformin's impact on IGF-1 appears to be more pronounced in hyperinsulinemic individuals or those with metabolic disorders, where insulin levels are elevated. In such cases, lowering insulin reduces hepatic IGF-1 production since IGF-1 synthesis is insulin-dependent. This reduction may be beneficial for longevity and conditions involving excessive IGF-1 signaling.
While these findings are supported by clinical and preclinical research, specific impacts vary depending on individual physiology and context of use .
www.mdpi.com
Metformin has been shown to lower IGF-1 levels through several mechanisms. By activating the AMPK pathway, Metformin reduces insulin and glucose levels, which can downregulate the IGF-1/IGF-1R signaling pathway. This reduction in IGF-1 activity is associated with Metformin's ability to inhibit the mTOR pathway, which influences cell growth, proliferation, and aging processes. These effects may contribute to Metformin's potential anti-aging and anti-cancer properties by lowering IGF-1's role in promoting cell proliferation and survival.
Metformin's impact on IGF-1 appears to be more pronounced in hyperinsulinemic individuals or those with metabolic disorders, where insulin levels are elevated. In such cases, lowering insulin reduces hepatic IGF-1 production since IGF-1 synthesis is insulin-dependent. This reduction may be beneficial for longevity and conditions involving excessive IGF-1 signaling.
While these findings are supported by clinical and preclinical research, specific impacts vary depending on individual physiology and context of use .
Metformin: The Winding Path from Understanding Its Molecular Mechanisms to Proving Therapeutic Benefits in Neurodegenerative Disorders
Metformin, a widely prescribed medication for type 2 diabetes, has garnered increasing attention for its potential neuroprotective properties due to the growing demand for treatments for Alzheimer’s, Parkinson’s, and motor neuron diseases. This review synthesizes experimental and clinical...
www.mdpi.com
iris
Well-known Member
Vigorous Steve + chat gpt + a resurrected Zyzz.
What could go wrong
What could go wrong
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