HGH inhibiting weight loss suppression of GLP-1’s

[bigtom343]

I use WebMD to check my meds and gear for interactions. The interaction that I’m most interested in is my 3-4 IU/ day HGH and 10mgTriz 0.6 mg Cagri weekly regimen.

WebMD states that HGH reduces the effectiveness of Triz and Sema. I’ve been on GLP’s for weight loss for over a year and managed to drop 50lbs. I’m now at a weight where I can consistently incorporate long distance running into my fitness regimen.

I started getting in on the QSC GB’s and their Discord this year. Their marketing was very catchy and had a lot of consumer enthusiasm around their products. It got me interested in doing HRT and TRT to help me reduce my physical pain from heavy exercise at age 40 as well as the anti-aging/biohacking benefits.

I’ve been doing the 2-4 IU HGH for about 6 weeks and I have noticed some benefits such as less knee pain and better rest at night.

I’ve been holding at the 10mg Tirz for 3months while slowly adding the Cagri to maintain the appetite suppression. My concern is that the HGH might interfere with the peptide regimen for weight loss. I’m starting to eat a little more everyday and took my son to a Korean bbq hotpot tonight

I’m concerned I’m about to break thru the hunger threshold on the Tirz. In the winter I broke thru the hunger threshold on 3-4 mg Semaglutide and switched over to Tirz. 10mg Tirz with the Cargi seemed like a good cruising maintenance dose for not gaining weight untill just now.

The question I’m asking myself is which direction do I need to go? Do I stop the low dose HGH? Do up the Tirz to 15mg & 2.4 mg Cargi? Add some Metformin? Go even harder (I wish) on the exercise? Switch to Reta?

If possible I’d like to wait till winter to switch to Reta because I’ve heard it helps you stay warm.
The discord bros insist that HGH and Triz and TRT together are the perfect combo for a lean physique. I’m not convinced and I’d like to get some more input.

 

[HB_22]

I don't feel like these drugs interact in any way. I tried rHGH with semaglutide, rHGH with tirzepatide. I couldnt feel any weakening effect of the glp-1 drugs.

 

[songsofpyramids]

Hgh and glp1 is like the hip new combo I thought? Glp1 keeps the hgh from screwing your insulin sensitivity, and the hgh keeps the glp1 from causing excess muscle wasting. I haven’t pulled the trigger on glp1 yet cause I hate stuff that messes with my stomach, but there’s seemingly a zillion ppl on that combo. Genuinely curious what others more informed think.

 

[mochul]

Hgh and glp1 is like the hip new combo I thought? Glp1 keeps the hgh from screwing your insulin sensitivity, and the hgh keeps the glp1 from causing excess muscle wasting. I haven’t pulled the trigger on glp1 yet cause I hate stuff that messes with my stomach, but there’s seemingly a zillion ppl on that combo. Genuinely curious what others more informed think.

You said it youself. Glp mitigates hgh insuline resistance. From a medical perceptive hgh makes the effects of glp1 less effective. Think as a doctor or a medicine researcher while reading scientific research.

 

[songsofpyramids]

You said it youself. Glp mitigates hgh insuline resistance. From a medical perceptive hgh makes the effects of glp1 less effective. Think as a doctor or a medicine researcher while reading scientific research.

Yeah, I get it, but that doesn’t make it ineffective, no? I’d rather lose no muscle and lose fat a little slower, than lose fat a little faster. Isn’t that partially why the cargj is in his stack too, for the muscle sparing? I guess it’s dependent on personal goals. It does sound like dropping weight asap if op’s goal so you’re right what I said might sound dumb.

On a separate note, could it help with the lose skin while loosing weight fast too? That could just be an assumption of mine based on my wrinkles getting better on hgh.

@op are you working out and have muscles to preserve now while also dropping weight? Are you just getting into exercise? Are you getting back into exercise after a long time? Where are you at in your journey? I think that’ll make it easier for people to give you suggestions of whether to save the gh for later in your progress or not.

 

[mochul]

Yeah, I get it, but that doesn’t make it ineffective, no? I’d rather lose no muscle and lose fat a little slower, than lose fat a little faster. Isn’t that partially why the cargj is in his stack too, for the muscle sparing? I guess it’s dependent on personal goals. It does sound like dropping weight asap if op’s goal so you’re right what I said might sound dumb.

On a separate note, could it help with the lose skin while loosing weight fast too? That could just be an assumption of mine based on my wrinkles getting better on hgh.

@op are you working out and have muscles to preserve now while also dropping weight? Are you just getting into exercise? Are you getting back into exercise after a long time? Where are you at in your journey? I think that’ll make it easier for people to give you suggestions of whether to save the gh for later in your progress or not.

Depends on your goal. Loosing fat? Yes they are effective together. Diabetes? They work against each other.
For fat loss the most important thing is calories in and out. Glp1 helps with appetite and hgh helps with muscle loss prevention and helps freeing fatty acids to be used as energy.

 

[songsofpyramids]

Depends on your goal. Loosing fat? Yes they are effective together. Diabetes? They work against each other.

From everything I’ve read the glp1 is so effective on the insulin sensitivity front that it would render the super moderate dose of hgh op is taking basically meaningless. Am I ignorant on that? My blood sugar didn’t change super drastically until I got to 8iu hgh personally. Genuinely interested because the reason I’ve eyed glp1 would be to push my hgh up to that level for longer than a month and see what happens, potentially with my first blast.

 

[AlexDavis43]

Am I ignorant on that?

No, GLP1's and hGH makes sense for the reasons mentioned above.

Although resistance training & good sleep hygiene will do a better job at preserving muscle than hGH. Others: testosterone & a higher protein diet.

 

[mjkt7311]

Anecdotally, on that exact stack with 3-4IU GH, it does not. Tirz + cagrilintide work almost a little too well.

 

[xrayphoton13]

I feel like some hunger came back after I started hgh

 

[Canuck83]

I use WebMD to check my meds and gear for interactions. The interaction that I’m most interested in is my 3-4 IU/ day HGH and 10mgTriz 0.6 mg Cagri weekly regimen.

WebMD states that HGH reduces the effectiveness of Triz and Sema. I’ve been on GLP’s for weight loss for over a year and managed to drop 50lbs. I’m now at a weight where I can consistently incorporate long distance running into my fitness regimen.

I started getting in on the QSC GB’s and their Discord this year. Their marketing was very catchy and had a lot of consumer enthusiasm around their products. It got me interested in doing HRT and TRT to help me reduce my physical pain from heavy exercise at age 40 as well as the anti-aging/biohacking benefits.

I’ve been doing the 2-4 IU HGH for about 6 weeks and I have noticed some benefits such as less knee pain and better rest at night.

I’ve been holding at the 10mg Tirz for 3months while slowly adding the Cagri to maintain the appetite suppression. My concern is that the HGH might interfere with the peptide regimen for weight loss. I’m starting to eat a little more everyday and took my son to a Korean bbq hotpot tonight

I’m concerned I’m about to break thru the hunger threshold on the Tirz. In the winter I broke thru the hunger threshold on 3-4 mg Semaglutide and switched over to Tirz. 10mg Tirz with the Cargi seemed like a good cruising maintenance dose for not gaining weight untill just now.

The question I’m asking myself is which direction do I need to go? Do I stop the low dose HGH? Do up the Tirz to 15mg & 2.4 mg Cargi? Add some Metformin? Go even harder (I wish) on the exercise? Switch to Reta?

If possible I’d like to wait till winter to switch to Reta because I’ve heard it helps you stay warm.
The discord bros insist that HGH and Triz and TRT together are the perfect combo for a lean physique. I’m not convinced and I’d like to get some more input.

You broke through a hunger threshold on 4mg of sema ?? You realize the safe weekly recommended dose is 2mg. You don't need drugs you need a muzzle

 

[Ghoul]

You broke through a hunger threshold on 4mg of sema ?? You realize the safe weekly recommended dose is 2mg. You don't need drugs you need a muzzle

Wait, you mean jumping around to different GLPs, combining them, probably dosing multiple times a week, has once again resulted in failure despite the plain old, boring, once a week, single Tirz or Sema protocol used in the pharma trials being effective at eliminating major weight and keeping it off for years for 95%+ of participants?

I'm shocked another "reddit protocol" user can't achieve what plain old once a week Sema does for the vast majority.

Well, we all know pharma doesn't know shit, so what you should try now is microdose daily, rotating .25mg Sema, 2.5mg Tirz, 2mg Reta, 1mg Cagri, then for three days combine all in a syringe as a single dose and restart the pattern.

I know someone who successfully lost 8lbs on that protocol, although despite doubling the dose of everything and going to twice a day injections it's slowly creeping back on.

The sizzling you may hear at night are your receptors frying and the hot spot that moves around your body is your immune system, now an expert on clearing these compounds, setting every GLP class molecule it can find on fire in a cytokine storm, including some of your endogenous GLP (whoops!).

 

[UncleBuns]

I use WebMD to check my meds and gear for interactions. The interaction that I’m most interested in is my 3-4 IU/ day HGH and 10mgTriz 0.6 mg Cagri weekly regimen.

WebMD states that HGH reduces the effectiveness of Triz and Sema. I’ve been on GLP’s for weight loss for over a year and managed to drop 50lbs. I’m now at a weight where I can consistently incorporate long distance running into my fitness regimen.

I started getting in on the QSC GB’s and their Discord this year. Their marketing was very catchy and had a lot of consumer enthusiasm around their products. It got me interested in doing HRT and TRT to help me reduce my physical pain from heavy exercise at age 40 as well as the anti-aging/biohacking benefits.

I’ve been doing the 2-4 IU HGH for about 6 weeks and I have noticed some benefits such as less knee pain and better rest at night.

I’ve been holding at the 10mg Tirz for 3months while slowly adding the Cagri to maintain the appetite suppression. My concern is that the HGH might interfere with the peptide regimen for weight loss. I’m starting to eat a little more everyday and took my son to a Korean bbq hotpot tonight

I’m concerned I’m about to break thru the hunger threshold on the Tirz. In the winter I broke thru the hunger threshold on 3-4 mg Semaglutide and switched over to Tirz. 10mg Tirz with the Cargi seemed like a good cruising maintenance dose for not gaining weight untill just now.

The question I’m asking myself is which direction do I need to go? Do I stop the low dose HGH? Do up the Tirz to 15mg & 2.4 mg Cargi? Add some Metformin? Go even harder (I wish) on the exercise? Switch to Reta?

If possible I’d like to wait till winter to switch to Reta because I’ve heard it helps you stay warm.
The discord bros insist that HGH and Triz and TRT together are the perfect combo for a lean physique. I’m not convinced and I’d like to get some more input.

Can you post a link to the source of information claiming HGH interferes with GLP 1 drugs? I haven't heard this before and am curious.

 

[Grey Spartan]

I feel like some hunger came back after I started hgh

Same. Albeit I am on a low dose (1mg sema) and the hunger is still easy to ignore even though I can hear Little Debbie calling to me. lol

 

[xrayphoton13]

Same. Albeit I am on a low dose (1mg sema) and the hunger is still easy to ignore even though I can hear Little Debbie calling to me. lol

Ha! When I was naturally hypogonadal tirzepatide worked so well. I lost over 100 lbs in under a year. Once I found out and started trt the hunger got worse. Then HGH made it worse. Now I've found running full on big cycles really brings the hunger back. I can be miserable bc semaglutide/tirz/reta is doing its thing and making gastric emptying super slow so I'm stuffed and gassy from both ends and have sulfur burps but I still want to eat more.

 

[Ghoul]

The only compound that works on the psychological portion of hunger is GLP. We may discover Sema is the best for suppressing appetite while on appetite stimulating compounds like AAS and HGH.

It's a shame to lose the health benefits and nausea reduction of GIP.

We can thank obamacare for this, incentivizing pharma developers to limit peptides to 39 amino acids or less. Tirz would've likely had more GLP affinity were it not for the obscure rule that makes peptides with over 40 amino acids less profitable.

 

[29trt]

Ha! When I was naturally hypogonadal tirzepatide worked so well. I lost over 100 lbs in under a year. Once I found out and started trt the hunger got worse. Then HGH made it worse. Now I've found running full on big cycles really brings the hunger back. I can be miserable bc semaglutide/tirz/reta is doing its thing and making gastric emptying super slow so I'm stuffed and gassy from both ends and have sulfur burps but I still want to eat more.

Sema is the same for me.... Higher AAS ,more workouts more intense appetite is not suppressed significantly until I feel so bloated that i cannot stuff my face anymore usually by meal 4.... 1.5mg max of sema ..but I am 200lbs well under 10% fat so there is that...

HGH actually helps with appetite for me , deca makes me eat the house mostly sweets

 

[bigtom343]

Can you post a link to the source of information claiming HGH interferes with GLP 1 drugs? I haven't heard this before and am curious.

Can you post a link to the source of information claiming HGH interferes with GLP 1 drugs? I haven't heard this before and am curious.

Drug Interaction Report: Mounjaro, somatropin

View detailed report of drug-drug and drug-food interactions for Mounjaro, somatropin

www.drugs.com

They seem to be working fine to me.

 

[AlexDavis43]

Can you post a link to the source of information claiming HGH interferes with GLP 1 drugs? I haven't heard this before and am curious.

GLP1 drugs improve insulin sensitivity. hGH does the opposite.

 

[UncleBuns]

GLP1 drugs improve insulin sensitivity. hGH does the opposite.

I'm aware of one causing insulin resistance in one causing insulin sensitivity. They actually pair together well for that. I was referring to the original poster saying they read that HGH REDUCES the effects of tirz and sema. I've never heard of HGH diminishing GLP 1 drugs appetite suppression.

I use WebMD to check my meds and gear for interactions. The interaction that I’m most interested in is my 3-4 IU/ day HGH and 10mgTriz 0.6 mg Cagri weekly regimen.

WebMD states that HGH reduces the effectiveness of Triz and Sema. I’ve been on GLP’s for weight loss for over a year and managed to drop 50lbs. I’m now at a weight where I can consistently incorporate long distance running into my fitness regimen.

I started getting in on the QSC GB’s and their Discord this year. Their marketing was very catchy and had a lot of consumer enthusiasm around their products. It got me interested in doing HRT and TRT to help me reduce my physical pain from heavy exercise at age 40 as well as the anti-aging/biohacking benefits.

I’ve been doing the 2-4 IU HGH for about 6 weeks and I have noticed some benefits such as less knee pain and better rest at night.

I’ve been holding at the 10mg Tirz for 3months while slowly adding the Cagri to maintain the appetite suppression. My concern is that the HGH might interfere with the peptide regimen for weight loss. I’m starting to eat a little more everyday and took my son to a Korean bbq hotpot tonight

I’m concerned I’m about to break thru the hunger threshold on the Tirz. In the winter I broke thru the hunger threshold on 3-4 mg Semaglutide and switched over to Tirz. 10mg Tirz with the Cargi seemed like a good cruising maintenance dose for not gaining weight untill just now.

The question I’m asking myself is which direction do I need to go? Do I stop the low dose HGH? Do up the Tirz to 15mg & 2.4 mg Cargi? Add some Metformin? Go even harder (I wish) on the exercise? Switch to Reta?

If possible I’d like to wait till winter to switch to Reta because I’ve heard it helps you stay warm.
The discord bros insist that HGH and Triz and TRT together are the perfect combo for a lean physique. I’m not convinced and I’d like to get some more input.