High blood presure (after COVID19?!)

BarbarianGainz

New Member
Hi all, I think this is my first post real post and phuuu I dont know where to start.

First of all, I´ve taken steroids since 3 years now and never inject more than 1g of steroids per week (Test, Mast, Primo, Npp and this year I tried Tren A)
During "cycle" I do 3-6 month of TRT. I start early with HGH after 1 year (max. 4 IU) during knee problems. And first of all my blood pressure at the begining was 120/80 and going up to 140/80 after 375mg Test on my first "year". I´ve taken 20mg Telmisartan, later 40mg Telmisartan. And later on, I´ve added 1,25mg Nebivolol up to 5mg Nebivolo. During "cycles" depens about the amunt of steroids I´ve injected I´ve mainly adjust the BP with Nebivolol (min. 1,25mg)

My problem is now, that I tried this year from april - july (175mg Test, 300mg Mast P, 300mg Tren A, 4IU HGH in combination with 40mg Telmisartan + 2,5mg Nebivolol) somehow my BP went up to 140/150 after it was in range and I´ve extend the dosis from 2,5mg nebivolol to 5mg which does the "trick" to lower the BP to 125/130. Alongside of that, I´ve noticed not much side effects of Tren. However, im on TRT since mid of July and Covid19 catched me (3rd time in my life) at the begining of august. Normally no side effects and was able to train after 2 weeks. Aftter 20 days, since I´ve revocerd from covid19 my problems started.

I´ve had some shortness of breath,strange behaviour of my heartrate (some days I was laying on my couch and had 100bpm for hours, and somedays I´ve runing with 40-50bpm around. And the biggest problem was I´ve notived some light dizziness and consciousness problems. But the strange behavour is, that the symptoms appeared completely unexpectedly and could not be deduced from anything.
However, now most of the symptomes are reduced and I´ve fight with the Bloodpresure which I am not able to get in range even that I am 4 month in TRT (150mg Test + 4IU HGH) I´ve tried to switch from 40mg Telmisartan to 16mg Candensartan, and I have the feeling that the BP gets up a little bit...

I´ve done multiple test with my doctor and till now im standing here with a big question mark since every investigation seems to be fine and in range.

-> Bloodwork (E2, hemoglobin, Hematocrit in Range) normaly fine
--> Hemoglobin was end on august at 16.7 (range 15.5-17.5) and mid september on other doctor it was by 18 (Range 15.5 - 17.1)
-> cardiologist which did an ultrasonic and checked everything.

My BP is on TRT higher than it was after 6month with 375mg Test, 300mg Primo, 300mg NPP on my bulk at 112kg at the end.
Im currently on 102kg@186cm.

Sorry for my bad english, maybe I´ve translated some words wrong. But im really thankfull for each hint you guys can give me...
 
Even after adjustment for relevant competing risk factors, DBP [+4.7 mmHg, 95% confidence interval (95% CI) 3.97–5.7, P < 0.001] was significantly higher in individuals after COVID-19. For SBP, a trend towards increased values was observed (+1.4 mmHg, 95% CI -0.4 to 3.2, P = 0.120). Hypertensive blood pressures at least 130/80 mmHg (according to the ACC/AHA guideline) and at least 140/90 mmHg (ESC/ESH guideline) occurred significantly more often in individuals after COVID-19 than matched controls (odds ratio 2.0, 95% CI 1.5–2.7, P < 0.001 and odds ratio 1.6, 95% CI 1.3–2.0, P < 0.001, respectively), mainly driven by changes in DBP.


 
This one is from way back in 2022.

The RAAS plays a key role in the cardiovascular system.<a href="Does COVID-19 Cause Hypertension? - PMC">19</a> It is well known that the hyperactivation of RAAS and increases in ANG 2 levels are related with adverse outcomes (via the ANG 1 receptors) in cardiovascular diseases including heart failure, hypertension, myocardial infarction, and diabetic cardiovascular complications.<a href="Does COVID-19 Cause Hypertension? - PMC">20</a> On the other hand, ACE 2 is an enzyme has a negative regulator role in RAAS activation mainly by converting ANG 1 and ANG 2 into ANG 1–9 and ANG 1–7, respectively. There is a balance between the protective arm ACE 2/ANG 1–7/Mas receptor axis and pathogenic arm ACE/ANG 2/ANG 2 receptor type 1 receptor axis.<a href="Does COVID-19 Cause Hypertension? - PMC">21</a> ACE 2 is also the cellular receptor for the SARS-CoV-2 that is responsible the infectivity of COVID-19. ACE 2 is widely expressed in the cardiovascular system and in the lung, as well. Considering that ACE 2 plays a negative role in RAAS, a decrease in the ACE 2 and an increase in the ANG 2 level may lead to increase in BP. In a cohort study circulating, ANG 2 levels were significantly elevated in COVID-19 patients when compared with healthy individuals and increase of ANG 2 was linearly correlated with virus load.<a href="Does COVID-19 Cause Hypertension? - PMC">22</a> Therefore, a direct link between ACE 2 down regulation and systemic RAAS imbalance may lead to increase ANG 2 levels and BP. Accordingly, the present study showed that both systolic and diastolic BP were significantly increased in COVID-19 patients in short term follow-up period. The new onset hypertension was observed in 18 patients at the end of the follow-up period.

 
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