High Estrogen and Itching

[Noneya14]

User name checks out.

 

[OldGHGuy]

Dry,cracked skin is literally open for histamine to reach tissue that reacts to it worse than the outside layer of your skin.

I have pretty severe allergies and it makes for constant itching in the winter.
High estrogen might cause some bloat, said bloat stretches your dry and brittle skin, there's the itching.

Might not be the case at all, but do moisturise before jumping on medication.

I, too, have a tendency to blame gear for all that ails me. But every once in a while, an issue isnt related at all. Good luck with it

 

[malomkarom]

I, too, have a tendency to blame gear for all that ails me.

Don't we all. It's the source of all good and evil.

Last time I had to make fun of myself publically cause I was convinced my energy and motivation is gone cause my test is bunk.

Turned out I just bought caffeine free coffee. I went from 500mg+ to 0 for 2 weeks.

 

[Itchyballs26]

Dry,cracked skin is literally open for histamine to reach tissue that reacts to it worse than the outside layer of your skin.

I have pretty severe allergies and it makes for constant itching in the winter.
High estrogen might cause some bloat, said bloat stretches your dry and brittle skin, there's the itching.

Might not be the case at all, but do moisturise before jumping on medication.

Yes but I get dry skin on my hands and scalp only (and always have). This itching is everywhere, I feel the dry air may exacerbate it but it's not the root cause.

 

[malomkarom]

Yes but I get dry skin on my hands and scalp only (and always have). This itching is everywhere, I feel the dry air may exacerbate it but it's not the root cause.

Everywhere else you have clothes on normally, atleast I hope.
It's the middle of winter, so unless you are from Uganda or Mordor, allergens don't really touch skin around there.

Also, when stretchmarks are created they itch like a motherfucker. Don't need to be huge either. Thats for both you and the marks.

 

[Itchyballs26]

Everywhere else you have clothes on normally, atleast I hope.
It's the middle of winter, so unless you are from Uganda or Mordor, allergens don't really touch skin around there.

Also, when stretchmarks are created they itch like a motherfucker. Don't need to be huge either. Thats for both you and the marks.

This doesn't explain why I have itching everywhere if dry skin was the cause.

Again your suggestion could well be the cause but I feel it's fairly low on the hierarchy of probable causes.

 

[Itchyballs26]

User name checks out.

Thankfully the symptoms don't actually affect said body part.

 

[malomkarom]

This doesn't explain why I have itching everywhere if dry skin was the cause.

Again your suggestion could well be the cause but I feel it's fairly low on the hierarchy of probable causes.

If histamine was the problem, histamine would have to reach the skin to cause serious ithching. For that do happen to a large enough degree the skin would have to be eexposed way more than it is in winter clothing.

For allergy symptoms to go systematic it has to be pretty severe and it sure as hell that itching would be the least of your concern.

Most oldschool antihistamines do a lot more than just block allergy symptoms which might also explain it going away after popping one, depending on the exact substance.

 

[Itchyballs26]

If histamine was the problem, histamine would have to reach the skin to cause serious ithching. For that do happen to a large enough degree the skin would have to be eexposed way more than it is in winter clothing.

For allergy symptoms to go systematic it has to be pretty severe and it sure as hell that itching would be the least of your concern.

Most oldschool antihistamines do a lot more than just block allergy symptoms which might also explain it going away after popping one, depending on the exact substance.

Histamine is released by mast cells in the blood stream big man lol. Therefore it can easily 'reach my skin'.

 

[OldGHGuy]

Don't we all. It's the source of all good and evil.

Last time I had to make fun of myself publically cause I was convinced my energy and motivation is gone cause my test is bunk.

Turned out I just bought caffeine free coffee. I went from 500mg+ to 0 for 2 weeks.

Hahaha now THATS funny!! Thanks for sharing

 

[malomkarom]

Histamine is released by mast cells in the blood stream big man lol. Therefore it can easily 'reach my skin'.

Would be an oustandingly weird reaction to get itching before serious shit.

 

[Itchyballs26]

Would be an oustandingly weird reaction to get itching before serious shit.

Who said anything about serious, systemic just means widespread as opposed to localised injection site itching.

 

[malomkarom]

Who said anything about serious, systemic just means widespread as opposed to localised injection site itching.

I know exactly what it means.

Before most people start itching enough to be a major symptom from a systematic reaction their airways and esophagus will start closing, they get serious eye, nasal and ear irritation, have a bad stomach, get minor circulatory problems and the list goes on.

If itching is all you can really describe, it's not allergies almost definitely.

I wish I wasn't educated on allergies but I wouldn't be alive if I wasn't. There aren't many things that couldn't kill me in quantities some of you are exposed to daily, probably not even knowing it's alergens.

Anyways, I won't argue with you over nothing, you aren't in danger and I've yet to say anything worthy of an argument, the most I said was it would be weird.

Afterall I exist, weird shit happens sometimes even though it isn't supposed to.

TLDR: You aren't alergic to estrogen.

It's either the dry skin being britle and stretching, or you might be bloated enough to pinch tiny vessels. You are fine. If you wanna take a mild antihistamine, feel free to take one that isn't dangerous.

 

[Itchyballs26]

I know exactly what it means.

Before most people start itching enough to be a major symptom from a systematic reaction their airways and esophagus will start closing, they get serious eye, nasal and ear irritation, have a bad stomach, get minor circulatory problems and the list goes on.

If itching is all you can really describe, it's not allergies almost definitely.

I wish I wasn't educated on allergies but I wouldn't be alive if I wasn't. There aren't many things that couldn't kill me in quantities some of you are exposed to daily, probably not even knowing it's alergens.

Anyways, I won't argue with you over nothing, you aren't in danger and I've yet to say anything worthy of an argument, the most I said was it would be weird.

Afterall I exist, weird shit happens sometimes even though it isn't supposed to.

TLDR: You aren't alergic to estrogen.

It's either the dry skin being britle and stretching, or you might be bloated enough to pinch tiny vessels. You are fine. If you wanna take a mild antihistamine, feel free to take one that isn't dangerous.

Thanks for the help Einstein. I didn't think I was "allergic to estrogen", I said the elevated estrogen MIGHT be causing the itching due to its effect on mast cells and histamine.

 

[Superchicken]

I plugged this into ChatGPT recently because it’s something two of my teen sons started dealing with. My husband mentioned that it happened to him in puberty, with infrequent recurrence since starting trt. I’ve had it my whole life varying in frequency, progressing to wheals and rash in my late 30s. I didn’t specifically ask about estrogen in men, but it’s in the summary since the mechanism is different for men and women.

Husband and the more severe son both have hyperhidrosis which contributes. The younger son has severe environmental and anaphylactic food allergies, and flares can be worse when system is overloaded with allergen exposure, but is likely to stabilize with age. 1 kid + me both have ehlers danlos, and explains why this will be an ongoing thing. Mentioning in case any apply. All of us are properly moisturized. The only advice it gave was to do more frequent test doses which my husband already does his eod, or to take an antihistamine since I’d said it helps. Mine doesn’t need a heat trigger.

AI summary
Heat‑Triggered Itch / Cholinergic Urticaria: Hormonal Mechanisms

1. Androgens (Testosterone / DHT): Sweat Signaling

• Androgens increase eccrine and apocrine sweat gland responsiveness.
• This amplifies acetylcholine signaling during heat or early exercise.
• Lower heat thresholds more easily trigger mast‑cell activation.

Effect: earlier and stronger prickly itch with warming or exertion.

2. Androgens: Sympathetic Nervous System Tone

• Testosterone increases sympathetic (adrenergic) tone.
• Core temperature rises faster with exertion or stress.
• Neural signaling to mast cells is intensified.

Effect: pins‑and‑needles itch during early exertion or anticipation of activity.

3. Estrogen: Mast Cell and Vascular Amplification

• Estrogen directly enhances mast‑cell histamine release.
• Increases vascular permeability and wheal formation.
• Slows histamine breakdown.

Effect: progression from itch alone to visible hives, especially with age or hormonal fluctuation.

Summary

• Androgens amplify heat and nerve triggers.
• Estrogen amplifies histamine effects and wheals.
• Antihistamines work because histamine is the final common pathway.