High oestradiol and prolactin

[Dog8999]

So I was on 1ml x2 a week (my last blast 4 months ago) now I’m cruising (not TRT before anyone shouts at me) my blood work came back fine other than hormones above (liver, kidney, red blood cells, white blood cells, clotting, cholesterol all good etc) now I’m going back to a blast 1ml twice a week. So I will take some Aromasin and get my hormones tested in another few weeks. Worried more about prolactin that Estrogen, but don’t want to jump the gun and take caber if Aromasin will bring them both down.

 

[Dog8999]

I’m also taking HCG x 2 a week would that affect anything?

 

[-Maui-]

I’m also taking HCG x 2 a week would that affect anything?

Yes, it is.
You have to worry about prolactin first. Aromasin will lower it, but not enough.
You should take caber 0.25mg once a week.
Take Aromasin 25mg twice a week until your next tests in 2-3 weeks ))

 

[Jin23]

Yes, it is.
You have to worry about prolactin first. Aromasin will lower it, but not enough.
You should take caber 0.25mg once a week.
Take Aromasin 25mg twice a week until your next tests in 2-3 weeks ))

Why wouldn't it be enough? Why do you think his prolactin is high?

If prolactin isn't an issue for the OP with normal physiological serum estrogen levels, it's safe to assume he hasn't an issue with prolactin hypersecretion - which seldom happens with high estrogen, due to it's dampening of dopaminergic neurons inhibitory action on prolactin release.

Estrogen also has some direct actions at stimulating prolactin release, as lactotrophes express estrogen receptors.

Giving out advice to use dopamine receptor agonists, prior to seeing what happens when e2 falls in range, is unwarranted.

 

[Dog8999]

Thanks, I didn’t want to jump the gun and take unnecessary caber. I’ll take 12.5mg a day of aromasin for this week and reduce to EOD next week and get bloods in 3/4 weeks and see where I am.

 

[Jin23]

reduce

Why

 

[Dog8999]

Why

Assumed ED would be too much would crash my e2?

 

[-Maui-]

Why wouldn't it be enough? Why do you think his prolactin is high?

If prolactin isn't an issue for the OP with normal physiological serum estrogen levels, it's safe to assume he hasn't an issue with prolactin hypersecretion - which seldom happens with high estrogen, due to it's dampening of dopaminergic neurons inhibitory action on prolactin release.

Estrogen also has some direct actions at stimulating prolactin release, as lactotrophes express estrogen receptors.

Giving out advice to use dopamine receptor agonists, prior to seeing what happens when e2 falls in range, is unwarranted.

Estradiol is not the only trigger of prolactin rise. This level of prolactin is atypical for this level of estradiol.
We'll wait and see. He's already started taking AI

 

[Dog8999]

Estradiol is not the only trigger of prolactin rise. This level of prolactin is atypical for this level of estradiol.
We'll wait and see. He's already started taking AI

No Ai taken in that blood work

 

[Jin23]

Estradiol is not the only trigger of prolactin rise. This level of prolactin is atypical for this level of estradiol.
We'll wait and see. He's already started taking AI

Normal levels are 2 - 18 ng/ml and he is at 37 ng/ml. Prolactinoma, if that is what you are referring to, is usually associated with much higher levels. While his levels are a bit higher then what you'd typically see, they still are in the realm of possibility. You have to account for genetic variability/susceptibility.

Op hasn't mentioned what his prolactin levels are with normal physiological estrogen levels, but I presume they are normal. (Op have you measured prolactin otherwise?) If this is true, then estrogen is the most likely culprit, especially if estrogen has been high for some time as it can not just stimulate prolactin release but also cause an increase in prolactin releasing cells.

However, measuring prolactin is a slight issue as the body releases prolactin as a stress response once the vein gets punctured, so levels can appear to be elevated when in reality they are not. It's the reason why you'd want multiple draws to determine proper levels. But at "such high levels", I'd discount this as a possibility.

There are lots of reason why prolactin can be somewhat elevated, stress being one of them but what other (likely) causes are you referring to?

 

[Dog8999]

No only had testosterone and all other blood work they didn’t test for estrogen/prolactin

 

[BigTomJ]

Iether your test is severly overdosed or you are bot injecting the right amount.

It's in nmol/l

That equates to over 2500ng/dl off of 200mg tear a week.


His trt is far too high

 

[BigTomJ]

Yes, it is.
You have to worry about prolactin first. Aromasin will lower it, but not enough.
You should take caber 0.25mg once a week.
Take Aromasin 25mg twice a week until your next tests in 2-3 weeks ))

This is bad advice. Plain and simple

 

[ThinkDeroid]

I had the same issue, now taking 0.25 caber e5d and it solved the issue.

 

[Dog8999]

It's in nmol/l

That equates to over 2500ng/dl off of 200mg tear a week.


His trt is far too high

Yep noted for future. How much aromasin I need to take to get down to reasonable levels is the evident question now I guess

 

[Dog8999]

I had the same issue, now taking 0.25 caber e5d and it solved the issue.

That wouldn’t bring estrogen down?

 

[ThinkDeroid]

That wouldn’t bring estrogen down?

No, but the prolactin.

 

[Dog8999]

No, but the prolactin.

Both are too high and I assume prolactin is the result of the high estrogen, will see after a few weeks of aromasin

 

[BigTomJ]

Yep noted for future. How much aromasin I need to take to get down to reasonable levels is the evident question now I guess

How much aromasin did you take during your blast? And what did your estrogen look like on blast.

Everyone responds differently. You can start with 12.5mg twice a week and retest in a couple weeks to see where that puts you.
There is no one size fits all answer. 12.5 x2 might be enough for you, it might not

 

[Dog8999]

How much aromasin did you take during your blast? And what did your estrogen look like on blast.

Everyone responds differently. You can start with 12.5mg twice a week and retest in a couple weeks to see where that puts you.
There is no one size fits all answer. 12.5 x2 might be enough for you, it might not

Didn’t have bloods done on blast, just after my cruise to make sure everything was ok before I blasted again. Will check again in few weeks. I took 12.5 e3d on last blast.