Histamine and Weight Loss

[corageon]

The science has been around for a while that histamine plays a pivotal role in our appetite and metabolism (1), and it is well-documented that drugs with high H(1) receptor antagonism demonstrate appetite stimulant and obesogenic effects(2)(3)(4).

In addition, drugs that stimulate Histamine release tend to decrease appetite and promote weight loss (such as modafanil and betahistine)(5)((6)(7).

I guess there is some moral to the story below...​

Is your anti-histamine making you fat? | THE LOW HISTAMINE CHEF


The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients.


Abstract
Histamine antagonism has been implicated in antipsychotic drug-induced weight gain. Betahistine, a histamine enhancer with H1 agonistic/H3 antagonistic properties (48 mg t.i.d.), was coadministered with olanzapine (10 mg/day) in three first-episode schizophrenia patients for 6 weeks. Body weight was measured at baseline and weekly thereafter. Clinical rating scales were completed at baseline and at week 6. All participants gained weight (mean weight gain 3.1+/-0.9 kg) and a similar pattern of weight gain was observed: an increase during the first 2 weeks and no additional weight gain (two patients) or minor weight loss (one patient) from weeks 3 to 6. None gained 7% of baseline weight, which is the cut-off for clinically significant weight gain. Betahistine was safe and well tolerated and did not interfere with the antipsychotic effect of olanzapine. Our findings justify a placebo-controlled evaluation of the putative weight-attenuating effect of betahistine in olanzapine-induced weight gain.

 

[corageon]

Also histamine plays a pretty devious role in Testosterone production as well.

NEUROCHEMICAL/ENZYMATICAL FACTORS INVOLVED IN TESTOSTERONE PRODUCTION
​

!.Histamine.!


Histamine acting via H1 receptors triggers GnRH (Gonadotropin-Releasing-Hormone), and thus triggers within the hypothalamus, production of LH (Luteinizing Hormone) and FSH (Follicle-Stimulating-Hormone) (1). LH signals the testes to increase the production of testosterone while, FSH, signals the production of enzymes like aromatase, stAR (steroidogenic-acute-regulatory-protein)(3) (4). Both LH, and FSH, are heavily involved in sperm production, fertility and general well-being (5) (6).

Histamine acting via H2 receptors; stimulates adenylyl cyclase, just like Forskolin extract; this increases cyclic AMP and subsequently, just like forskolin, increases testosterone production(7) (8) (9). H2 receptors also increase Ca2+ (Calcium Voltage Channels) (10) (11). This leads to increases in many neurotransmitters; AcH (Acetylcholine), GABA (Gamma-Amino-Butyric-Acid), Glut (Glutamate), Serotonin, and Dopamine (12) (13).


Histamine acting via H3 receptors, decreases histamine release as an autoreceptor, this decreases the effects mentioned above(14)(15).

So, how do we optimize histamine-induced testosterone production ?
By keeping histamine levels moderate, but yet not too high, not enough to cause allergic problems.
Make sure you are getting enough Folic Acid, Vitamin B12, L-Histidine, and protein in general in your diet. Also keep enough Zinc in your diet so you are zinc dominant. Zinc opposes Copper, and Copper can decrease histamine(16) (17).​

 

[Dr JIM]

You know Contagion you should be embarassed to post crap like this, as legitimate support for Histamine and/or it's receptors having an direct or indirect impact on testosterone levels or having ANY INFLUENCE on skeletal muscle anabolism.

IT'S UTTER NONSENSE

 

[corageon]

You know Contagion you should be embarassed to post crap like this, as legitimate support for Histamine and/or it's receptors having an direct or indirect impact on testosterone levels or having ANY INFLUENCE on skeletal muscle anabolism.

IT'S UTTER NONSENSE

I was actually referring to the first part, on appetite and weight loss. The second part was just a neat addition,