HMG as opposed to HCG

masterpp

New Member
does any one out there use HMG. is it advantagiouse to hcg (with regards to mainting testicular function whilst on trt)
also i dont really understand how using hcg alone can maintain fertility, as it is only an LH analogue.
su
 
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Actually, I have found articles stating it actually has properties of both LH and FSH. If I can find it again I'll post the link.
 
Found em again!

From http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/SexHormones.html
"HCG is a glycoprotein. It is a dimer of the same alpha subunit (of 89 amino acids) used by TSH, FSH, and LH) and a unique beta subunit (of 148 amino acids). HCG behaves much like FSH and LH with one crucial exception: it is NOT inhibited by a rising level of progesterone."

From http://www.ferringusa.com/fertility_products/insert_novarel.htm
"Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta, is composed of an alpha and a beta sub-unit. The alpha sub-unit is essentially identical to the alpha sub-units of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human thyroid-stimulating hormone (TSH). The beta sub-units of these hormones differ in amino acid sequence."

From http://www.dpcweb.com/medical/reproductive_endocrinology/molecular_dimers.html
"Molecular dimers are compounds containing two noncovalently associated molecular constituents: subunits A and B. Glycoproteins HCG, FSH, LH and TSH all share an identical subunit A."

From http://health.yahoo.com/ency/healthwise/hw201764
"Human chorionic gonadotropin (hCG) is similar to LH; it contains equal amounts of LH and FSH."

Yeah, they all pretty much say the same thing.
 
SPE said:
Yep. That's a good thread, thanks for the link.

masterpp: hCG is inexpensive and sufficient for the vast majority of men. If later in life you are trying to reproduce and you have trouble, then at that time it might be appropraite to try adding HMG to the mix.

HMG is usually prescribed on top of existing hCG therapy when it is prescribed.
 
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