How long does HGH last once mixed at room temp?

[rsmainz]

Ive seen the Janoshik report of GH losing almost 50% potency after being reconstituated and left at room temperature for 6 days, but do you think 12-16 hours @ room temp will have much of a degradation effect? Cant really find any info on how quickly it starts degrading

 

[boiwalker6548]

room temp = death, why dont you refrigerte it, 16 hours should be fine imo

 

[rsmainz]

room temp = death, why dont you refrigerte it, 16 hours should be fine imo

Not sure guess I'll start doing it again. Used to run 20-30iu daily so never really bothered with the fridge

 

[Ateam2023]

bump

 

[Ateam2023]

Not sure guess I'll start doing it again. Used to run 20-30iu daily so never really bothered with the fridge

20-30 iu daily? yeah right!

 

[rsmainz]

20-30 iu daily? yeah right!

Not sure why thats hard to believe, many people have done so and continue to do it, cut back to 15 due to funds

 

[Ateam2023]

Not sure why thats hard to believe, many people have done so and continue to do it, cut back to 15 due to funds

so your taking a minimum of 15 ius of hgh daily?

 

[Ateam2023]

whats your fbg on that much hgh? Do you take anything like metformin for bg control?

 

[rsmainz]

so your taking a minimum of 15 ius of hgh daily?

Yes...Im not sure why this is relevant at all, pm me if you want to continue this discussion, just want my main question answered haha

 

[Ateam2023]

Yes...Im not sure why this is relevant at all, pm me if you want to continue this discussion, just want my main question answered haha

good luck with that original question

 

[BuildABro]

Reconstituted peptides, per Jano, need to go in the fridge and have about a 30 day shelf life.

 

[FuriousGrill]

Looking for an answer here as well; I'm going to be traveling on train soon and will be carrying some prefilled HGH syringes with me (in an insulin cooler bag). I wonder how long I have before it starts to deteriorate...

 

[AlexDavis43]

bump

you bumped a thread 3 hours after it was posted

 

[Ateam2023]

you bumped a thread 3 hours after it was posted

it was a ridiculous question imo , but then again if people did "more research " they would most likely answer there own questions

 

[Ateam2023]

slightly early bump i agree , carry on boys lemme know the outcome please , tia ,,,,,

 

[rsmainz]

it was a ridiculous question imo , but then again if people did "more research " they would most likely answer there own questions

If its so ridiculous i'd be more than happy to hear your answer, considering theres another thread running on a somewhat similar topic it seems its a question that people want an answer too

 

[Ateam2023]

If its so ridiculous i'd be more than happy to hear your answer, considering theres another thread running on a somewhat similar topic it seems its a question that people want an answer too

i obviously don't have an answer, as it appears no one else does either , limited at best anyway, im eager for learning more about this too,,,,,

 

[readalot]

Ive seen the Janoshik report of GH losing almost 50% potency after being reconstituated and left at room temperature for 6 days, but do you think 12-16 hours @ room temp will have much of a degradation effect? Cant really find any info on how quickly it starts degrading

Fig.1
hGH stability in Tris and phosphate buffers (0.05 M, pH=7.4) analyzed by HPLC and ELISA tests. A. At 5 ± 2℃ and B. At 37 ± 1℃. hGH; Human growth hormone, HPLC; High performance liquid chromatography, and ELISA; Enzyme-linked immunosorbent assay


See the phosphate buffer data sets at 5 deg C and 37 deg C:

Figure - PMC

It is so difficult to formulate human growth hormone (hGH) in a solution with high stability and new drug delivery system (NDDs) due to physiochemical instability. The purpose of this study was to investigate the possibility of using Tris as a hGH ...

www.ncbi.nlm.nih.gov

Cool data as they give you the HPLC and ELISA responses.

You could try to interpolate these data to get an effective rate constant at 25 deg C for both physical and chemical degradation (try typical Arrhenius plot and it's a straight line as only two data points).

 

[readalot]

i obviously don't have an answer, as it appears no one else does either , limited at best anyway, im eager for learning more about this too,,,,,

See those bumps work. If I get a chance I will do the 25 deg C analysis for that above and beyond service I know Meso has come to expect.

 

[readalot]

but do you think 12-16 hours @ room temp will have much of a degradation effect?

See above. Long story short...not too bad without doing a bunch more work. Nonlinear Eyeballing.