IGF1 got lower on cjc dac

[Proud Pangolin]

I ordered cjc dac from qsc in 2024 mid december, it came as red caps. Ive been using it twice weekly for some time, did a blood test and my igf1 came lower by 20%. Does anyone know why this could be? Im concerned its not cjc dac. Im on a cut right know, but not a crazy one(+150g protein, 2000 calories)

Injecting a GHRH on its own is not very effective since you are unable to know when your bodies somatostatin is active. Because of this you'll need to pick a GHRP to be paired with your GHRH of choice. This ensures that
Somatostatin, if present, will be suppressed and the two peptides will synergistically amplify the natural GH pulse.

CJC-1293 is GRF(1-29) with 1 amino acid swap plus the Drug Affinity Complex (DAC). DAC acts as a velcro holding the amino acids together for a longer period of time. The
single amino acid swap makes the analog peptide stronger but not by enough. The half-life is maybe double GRF(1-29)in humans. So 5 minutes of half-life.
CJC-1295 is GRF(1-29) with 4 amino acid alterations and
the Drug Affinity Complex (DAC). This version is extra
strong and will last more than 30 minutes and the DAC
increases the half-life even more by preventing breakdown
by blood enzymes.

Here is the interesting part: You do not want to use any of
the CJC's. The first (CJC-1293) does not survive long
enough after injection and the second (CJC-1295) survives for too long and is always around preventing Somatostatin from stopping GH release resulting in a GH bleed.
What do you want to use? You want an analog that utilizes those 4 amino acid swaps and mantains the ability to still be broken down after those 30 or so minutes. This is
known as Modfied GRF(1-29).

 

[Middus]

Injecting a GHRH on its own is not very effective since you are unable to know when your bodies somatostatin is active. Because of this you'll need to pick a GHRP to be paired with your GHRH of choice. This ensures that
Somatostatin, if present, will be suppressed and the two peptides will synergistically amplify the natural GH pulse.

CJC-1293 is GRF(1-29) with 1 amino acid swap plus the Drug Affinity Complex (DAC). DAC acts as a velcro holding the amino acids together for a longer period of time. The
single amino acid swap makes the analog peptide stronger but not by enough. The half-life is maybe double GRF(1-29)in humans. So 5 minutes of half-life.
CJC-1295 is GRF(1-29) with 4 amino acid alterations and
the Drug Affinity Complex (DAC). This version is extra
strong and will last more than 30 minutes and the DAC
increases the half-life even more by preventing breakdown
by blood enzymes.

Here is the interesting part: You do not want to use any of
the CJC's. The first (CJC-1293) does not survive long
enough after injection and the second (CJC-1295) survives for too long and is always around preventing Somatostatin from stopping GH release resulting in a GH bleed.
What do you want to use? You want an analog that utilizes those 4 amino acid swaps and mantains the ability to still be broken down after those 30 or so minutes. This is
known as Modfied GRF(1-29).

In the Trials, the once weekly injections of CJC+DAC raised plasma GH by as much as 10 fold in some people and it remained elevated for 5-6 days. IGF-1 levels were as high as 6 fold for 8 days. It should work if he is injecting it in the right amounts. May just need to watch is pituitary gland as clinical trials never lasted long enough to evaluate that part in humans