Yes this is exactly what I did and it works perfectly, It's 10 g of powder total.. you can mix up the glutathione and bac water first and have the stir bar turned on, It just looks like a snow globe because it doesn't dissolve worth of shit, then as soon as you add the six grams of carnitine, It will turn crystal clear, then you can top it off with bac to get exactly 20 ml, I forget how many mils of bac I started with.. 8 or 10 maybe.. you have to factor in the displacement of the powder so you don't just start with 20 mils of bac water, you start with less, make it hold into the solution, then top it off
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Injectable Glutathione Recipe
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Photon
Member
I don't know either, it dissolves.
If you scroll up, others are using 600/ml too.
It does take awhile to dissolve.
You can google how an insulin pen works, you basically fill it up with a liquid of your choice, up to 3ml and inject when you want to by inserting a needle into the pen and jabbing yourself. Same as how diabetics handle insulin.
@Photon is using a ready made product from a Korean cosmetic lab, which is buffered (ph-balanced) before being lyophilised. You are using raw reduced glutathione powder.
I would presume it’s like adding NAoH or sodium bicarbonate before being made into a puck.
Room temperature, I never turned the heat on once. Like I said, It looks like a snow globe when you throw the 4 grams of glutathione in bac water with stir on. As soon as you start adding L-Carnitine, It will begin to clear up little by little, or almost instantaneously If you just dump all six grams in it once. I tried both ways to see if I could use less L-Carnitine. So yeah in theory, you could just get a glass jar and something to stir with, sterilize everything first, and mix it up, you shouldn't need any special equipment. Before I bought a hot plate, I used to love mason jars like you use for canning, you can buy a box of them under 10 bucks at the store with brand new lids, they are damn tough in heat or cold. I still struggle to stop using them even though I bought proper lab glassware. You can take one full of something, shake it, swirl it ,or sit it right down in boiling water with the lidd screwed on tight, and they won't crack, they're extremely tough.
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Okay that makes complete sense... Thanks for the reply.
Photon
Member
I did wonder if it was bunk since everyone was complaining about
Its not about buffered (or not), he's asking about the concentration of the gluthathione (300 mg/ml vs 600mg/ml).
L-Carnitine (600 mg/ml) is actually pretty thick..maybe thats why you cant increase the gluthathione concentration. Try using something else to buffer.
Its not about buffered (or not), he's asking about the concentration of the gluthathione (300 mg/ml vs 600mg/ml).
L-Carnitine (600 mg/ml) is actually pretty thick..maybe thats why you cant increase the gluthathione concentration. Try using something else to buffer.
I have sodium hydroxide that came in today,I'm going to do it that way and skip the l carnitine all together,now that I have a decent ph meter to work with, I should be able to get a fairly high concentration that way.. I will know this week exactly how strong I can push it.. I imagine 600mg just like everybody else is doing
I did 400mg/ml my last batch of glutathione with NaOH and its completely painless. It shoots just fine with a 29g slin pin too. I will probably try 600mg/ml next time.
Photon
Member
I just finished my second batch, and this time I added hydroxocobalamin (vitamin B12).
17 ml of bacteriostatic water
17 g of L-carnitine base
6 g of reduced glutathione
2 ml (10 mg) of hydroxocobalamin
1.2 g of sodium bicarbonate
Final pH: 6.5
Total volume: 36 ml
Final concentrations:
Carnitine: 470 mg/ml
Glutathione: 170 mg/ml
Vitamin B12: 0.28 mg/ml
I added the B12 ampoule at the very end of the preparation.
will inject 2 ml on the days I target large muscles, and 1 ml on the days I inject into smaller muscles.
17 ml of bacteriostatic water
17 g of L-carnitine base
6 g of reduced glutathione
2 ml (10 mg) of hydroxocobalamin
1.2 g of sodium bicarbonate
Final pH: 6.5
Total volume: 36 ml
Final concentrations:
Carnitine: 470 mg/ml
Glutathione: 170 mg/ml
Vitamin B12: 0.28 mg/ml
I added the B12 ampoule at the very end of the preparation.
will inject 2 ml on the days I target large muscles, and 1 ml on the days I inject into smaller muscles.
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JustJoe
New Member
Glutaone brand Korean Glutathione is buffered with sodium bicarb
JustJoe
New Member
Buffering with Bicarb is preferred over NaOH, because buffering with NaOH can rarely cause kidney stones or Stevens Johnsons syndrome.
NaOH can be used to change the pH rapidly but doest actually buffer the solution, and can cause oxidation or degradation of the glutathione, whereas bicarbonate will help keep it stable in solution on the shelf.
Also, buffering with NaHCO3 has synergistic effects
Administering glutathione in a buffered solution with bicarbonate may explain its improved tolerance to epithelia and provide synergistic efficacy via two complementary mechanisms: antioxidation of disulfide bonds combined with improved mucin processing by bicarbonate
but working with bicarb takes patience bc it's sometimes hard to dissolve and it doesnt change the pH of a solution as quickly as NaOH
pmc.ncbi.nlm.nih.gov
NaOH can be used to change the pH rapidly but doest actually buffer the solution, and can cause oxidation or degradation of the glutathione, whereas bicarbonate will help keep it stable in solution on the shelf.
Also, buffering with NaHCO3 has synergistic effects
Administering glutathione in a buffered solution with bicarbonate may explain its improved tolerance to epithelia and provide synergistic efficacy via two complementary mechanisms: antioxidation of disulfide bonds combined with improved mucin processing by bicarbonate
but working with bicarb takes patience bc it's sometimes hard to dissolve and it doesnt change the pH of a solution as quickly as NaOH
Novel Therapy of Bicarbonate, Glutathione, and Ascorbic Acid Improves Cystic Fibrosis Mucus Transport - PMC
Defective airway mucus clearance is a defining characteristic of cystic fibrosis lung disease, and improvements to current mucolytic strategies are needed. Novel approaches targeting a range of contributing mechanisms are in various stages of ...
pmc.ncbi.nlm.nih.gov
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JustJoe
New Member
also, Glutathione itself will buffer ascorbic acid, so if youre making a big Vitamin shot, throw some in there haha
So I did some experimenting myself tonight.. And what I've come to the realization is,
That's not 100% fact It might be with that particular brand, but I actually researched it a little bit and several brands actually do use NAOH , So I'm going to go with not every manufacturer uses the same buffer... If you actually follow a link somebody has on here to a place in China that sells 10 vials in a kit, there are instructions linked on the website and if you read them carefully it explains how to make a buffered solution with NAOH, to prepare the vials in the kit. Some kits do you not come buffered and I tracked down several places that sell the vials , because I considered buying them before I decided to make my own.Buffering with Bicarb is preferred over NaOH, because buffering with NaOH can rarely cause kidney stones or Stevens Johnsons syndrome.
NaOH can be used to change the pH rapidly but doest actually buffer the solution, and can cause oxidation or degradation of the glutathione, whereas bicarbonate will help keep it stable in solution on the shelf.
Also, buffering with NaHCO3 has synergistic effects
Administering glutathione in a buffered solution with bicarbonate may explain its improved tolerance to epithelia and provide synergistic efficacy via two complementary mechanisms: antioxidation of disulfide bonds combined with improved mucin processing by bicarbonate
but working with bicarb takes patience bc it's sometimes hard to dissolve and it doesnt change the pH of a solution as quickly as NaOH
Novel Therapy of Bicarbonate, Glutathione, and Ascorbic Acid Improves Cystic Fibrosis Mucus Transport - PMC
Defective airway mucus clearance is a defining characteristic of cystic fibrosis lung disease, and improvements to current mucolytic strategies are needed. Novel approaches targeting a range of contributing mechanisms are in various stages of ...
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I also did some experimenting tonight.. And what I came to the realization was, 200 mg/ml is damn easy to pull off, 600mh/ml or higher is not, And you will never do it with 10% naoh, I spent several hours and did several batches until I got it down.. when you reach that concentration it does lose the watery consistency and start to get thicker, and it simply will not dissolve until you get it above a pH of 5, and 10% sodium hydroxide solution doesn't even touch it when it's that strong what you end up doing is adding so much of it, to bring the pH up that you end up watering the living f*** out of it and you lose your concentration completely. I did get the process down fairly well, you have to get The tip of a knife or something very small and put very tiny crystals of food grade sodium hydroxide in it while it's stirring and continuously check it with the pH meter, And that prevents you from watering the living f*** out of it and keeping your high concentration, I was able to get a perfect 7.0 pH and a completely clear solution at 600 or 700 mg/ ml.. honestly it might be higher, because I did slightly pass 7.0, so I added a little bit more glutathione to it to drop it back down, and settled on 6.8... you can pretty much play with it like that bringing it up or down with one or the other, but I basically got a perfectly clear solution just like I did with the L-Carnitine but way stronger and I'm pretty happy with the results. I'm glad I bought a couple pounds of food grade sodium hydroxide and not just a solution because I would have been fucked, My whole point in doing this was to get a high concentration like the pharmaceutical places are selling, not just 200mg. I don't know if this helps anybody but that's the best way I can explain it... I tried the baking soda method like he suggesting above several weeks ago and the only thing I ended up with was a bunch of wild ass fizzing and bubbling, And it actually made everything really cloudy, because the baking soda wouldn't dissolve.... It also had no effect on the pH which was what I was adding it for anyways... perhaps somebody else might have better luck with that but that's not something I want to try again I'm pretty satisfied with what I've figured out.
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I forgot to add ,It starts to go into solution really well as soon as you get around a pH of 5.0 ... You will start out at 3 something, And it's not very soluble at that point but as soon as you get around 5.0, that's when it really starts to clear up.. It's not necessary to take it to a 7.0 to get it crystal clear but I did anyways because that seems like the most neutral solution as far as injecting something..I don't know if it's necessary to use food grade sodium hydroxide but I did anyways since it's something we are injecting, If it's safe enough to eat I'm sure it's safe enough to inject. You still have to add Crystal's probably.. five times I'm guessing.. you only add a few beads at a time, And it'll bring the pH up about .5 each time.. you just have to be careful The very first time I did it, I was trying to get a feel for how much it would take and I over shot it up to a 10.0 and had to toss that batch out. If I was guessing by eyeballing it, I would say like 10 or 20 mg at a time
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I suppose the next thing that I would like to figure out.. what percentage of NAOH will buffer a concentration of glutathione that is this high.. It would be nice to be able to pull a milliliter of solution up in a syringe and drip a few drops to adjust the pH..if somebody decides to figure that out, please post your results up I would love to see what you come up with!! I have 25 mL of glutathione already made up, It's going to take me a little bit to use that much up so I probably won't be making any more for a bit. I'm thinking of starting at 50% at least next time. I suppose sodium bicarbonate could be used, It has a pH of 8.3 and could be removed through filtering once it was pH balanced out... It is something worth trying I suppose...
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