Injectable Glutathione Recipe

[Sampei]

What type of source of it?
UGL? Made in China? Retail?

I'm planning to do lab work to check plasma glutathione levels in a few months to see if my glut is degrading after 6 months of use. Would be interesting to see how it compares to lipo.

3g lipo vs 700mg IM?

Shoot me a message when you do it, I'll contribute to the test cost.

Or we could send a gluta vial to check if it has degraded into GSSH

 

[Photon]

Shoot me a message when you do it, I'll contribute to the test cost.

Or we could send a gluta vial to check if it has degraded into GSSH

Its bloodwork, not Jano tho

 

[Sampei]

Its bloodwork, not Jano tho

Well if its expensive I'll gladly chime in

 

[MapleAUS]

What type of source of it?
UGL? Made in China? Retail?

I'm planning to do lab work to check plasma glutathione levels in a few months to see if my glut is degrading after 6 months of use. Would be interesting to see how it compares to lipo.

3g lipo vs 700mg IM?

Made in china

 

[MapleAUS]

Here’s it all

 

[Deadpool99]

I was referring to his statement of using premade glutathione lyophilized vials and not being able as you clearly stated to have 600-700mg/ml solution. it's utter nonsense we both just stated it

I well know that when we do our own glutathione the solution can be more or less concentrated depending on the buffer we use, I have tested buffered glutathione and at 30 days there was 0 degradation. Not sure past 30 days tho.

Not sure we can achieve the same buffer tho... I'm conflicted on what kind of buffer use, maybe a mix of NaOH and sodium bicarbonate?

If I can''t achieve 600mg/ml it becomes kinda useless to brew it myself, as I don't like to pin everyday so those 600mg/ml x2 a week is what I wanna achieve.

So I’m trying to reach a conclusion on the best practices for glutathione.

Lots of information to discover and get right.

I hope you guys don’t mind me asking some questions. I have read this entire forum but still a bit confused.

Question 1: So have you or anyone tried diluting Korean Glutathione 1200mg kits with 1.3ml of bac water? Which would total at 2ml after displacement of 0.7ml. (600mg/ml)

I wanted to keep my concentration around 600mg/ml as I would like to do 600mg daily.

Question: Subq vs IM, does it affect frequency, tho I plan to do daily anyways?

First wanted to go subq but now I think using a 1inch 30g into my quad as it seem to be just better to avoid any absorption or pip issues.

And I think it’s overall better, well I’m not very knowledgeable but I think the literature suggests + chatgpt that:

- 2-3x IM 600-1200mg injections per week could equate to 200-400mg subq daily due to IM better bioavailability so daily IM would do wonders from the basis of chatgpt.

 

[Sampei]

So I’m trying to reach a conclusion on the best practices for glutathione.

Lots of information to discover and get right.

I hope you guys don’t mind me asking some questions. I have read this entire forum but still a bit confused.

Question 1: So have you or anyone tried diluting Korean Glutathione 1200mg kits with 1.3ml of bac water? Which would total at 2ml after displacement of 0.7ml. (600mg/ml)

I wanted to keep my concentration around 600mg/ml as I would like to do 600mg daily.

Question: Subq vs IM, does it affect frequency, tho I plan to do daily anyways?

First wanted to go subq but now I think using a 1inch 30g into my quad as it seem to be just better to avoid any absorption or pip issues.

And I think it’s overall better, well I’m not very knowledgeable but I think the literature suggests + chatgpt that:

- 2-3x IM 600-1200mg injections per week could equate to 200-400mg subq daily due to IM better bioavailability so daily IM would do wonders from the basis of chatgpt.

600mg/ml is doable but its gonna hurt a bit and you must do it IM.

Its a lot tho 600mg daily IMHO

Do 300mg and dilute it down to 300mg/ml pipless

 

[Deadpool99]

600mg/ml is doable but its gonna hurt a bit and you must do it IM.

Its a lot tho 600mg daily IMHO

Do 300mg and dilute it down to 300mg/ml pipless

you mean painful IM as well?

Do you believe IM would require less aggressive dosing so maybe less than 600mg or maybe even lesser frequency?

This is whats intrigues me the most, however many success stories like @Photon’s bloodwork was based on daily shots at high concentrations (although he started subq then went IM and Idk if frequency changed), so that’s what lead me to my high dosages.

Also idk if chasing the “IM = less frequency” is accurate, as I said not the most knowledgeable here. The though process was maybe 4x a week instead of going daily if its IM, could just be another ChatGpt myth/propaganda. But clinically speaking IM is superior.

I guess I can go 400mg/ml for convenience of dosing.

FYI bot asking for ppl to just hand out the answers, I’d like to gather everyone thoughts and experiences and reach my own conclusions and test for myself.

I have been dealing with 50-60s, sometimes 70s liver enzymes even as a natural, so trying to get it to normal would be a breakthrough. (Always low GGT tho). Never got drawn to orals for it’s risk to reward in terms of pure lean muscle gain, so thankfully it’s not a major issue for me. But chasing better liver support and possibly dumping useless liver supplements is worth it.

 

[Sampei]

I have been doing 2x shot of 600mg/ml twice a week when not using any toxic substance and I'm doing now 300mg daily using anadrol and tren.

In my opinion 300mg/ml will be more than enough. Daily is better as gluthatione is short lived in the body for what I have gathered but I'm not a doctor neither an expert on the matter.

Yes at 600mg/ml it is painful not craze painful but it will hurt for a bit like 30 minutes.

300 is painless I would prefer to do 2ml of 300mg/ml instead of 1ml 600mg
But that's me, try for yourself

 

[Deadpool99]

I have been doing 2x shot of 600mg/ml twice a week when not using any toxic substance and I'm doing now 300mg daily using anadrol and tren.

Mind asking if you have bloods/liver enzymes pre and post glutathion and if u use any other oral supplements for liver like tudca/nac/sam-e?

Yes at 600mg/ml it is painful not craze painful but it will hurt for a bit like 30 minutes.

Gotcha, cheap ass = conserving my bac water supply.

Holy shit Imma need to order a 25pack of bac water at this point, shit ain’t cheap.

Daily is better as gluthatione is short lived in the body for what I have gathered but I'm not a doctor neither an expert on the matter.

Yeah, well not the best source but ChatGpt’s assumption based ok clinical data was:

• IM: gives a short but strong pulse → flips hepatic antioxidant systems fully “ON” → benefit persists 2–3 days even after GSH clears.
• SubQ: gives slow, small inputs → never fully activates that switch → so effect only lasts while levels are slightly elevated → needs daily repetition.

Clinical takeaway

The reason IM lasts longer functionally even though it clears faster is because it hits hard enough to induce a biological adaptation — not because it lingers in blood.

SubQ doesn’t cause the same level of activation; it’s like dripping water onto a switch instead of flipping it.

Real clinical difference​

Parameter	IM pulse	SubQ trickle
Plasma GSH rise	Sharp, large (~2–3× baseline)	Mild, slow (~1.2–1.5× baseline)
Enzyme response (Nrf2, GPx, GR)	Full activation, lasts 2–3 days	Partial activation, fades faster
Injection frequency	2–3×/week	Daily or EOD to maintain steady effect
Use case	Hepatic recovery, liver enzyme normalization	Maintenance antioxidant support

 

[Deadpool99]

Mind asking if you have bloods/liver enzymes pre and post glutathion and if u use any other oral supplements for liver like tudca/nac/sam-e?



Gotcha, cheap ass = conserving my bac water supply.

Holy shit Imma need to order a 25pack of bac water at this point, shit ain’t cheap.



Yeah, well not the best source but ChatGpt’s assumption based ok clinical data was:

• IM: gives a short but strong pulse → flips hepatic antioxidant systems fully “ON” → benefit persists 2–3 days even after GSH clears.
• SubQ: gives slow, small inputs → never fully activates that switch → so effect only lasts while levels are slightly elevated → needs daily repetition.

Clinical takeaway

The reason IM lasts longer functionally even though it clears faster is because it hits hard enough to induce a biological adaptation — not because it lingers in blood.

SubQ doesn’t cause the same level of activation; it’s like dripping water onto a switch instead of flipping it.

Real clinical difference​

Parameter	IM pulse	SubQ trickle
Plasma GSH rise	Sharp, large (~2–3× baseline)	Mild, slow (~1.2–1.5× baseline)
Enzyme response (Nrf2, GPx, GR)	Full activation, lasts 2–3 days	Partial activation, fades faster
Injection frequency	2–3×/week	Daily or EOD to maintain steady effect
Use case	Hepatic recovery, liver enzyme normalization	Maintenance antioxidant support

Ik many hate ChatGpt, not citing it as a valid source but trying to understand the thought process and Pharmacokinetics.

 

[MapleAUS]

So nobody has a solid reason for the use of injectable, rather than liposomal?

 

[Photon]

So nobody has a solid reason for the use of injectable, rather than liposomal?

unknown absorption rate.
normal glut has oral bioavailability <5%.

liposomal improves it, but it's not going to be anywhere near 100%.
it depends on how it's made etc, too many unknown factors.
it may be 10%, less, or more.
the websites that write of liposomal having high absorption rates are all selling it and have no proof etc. it's just marketing.

injectable is close to 100% absorption.

 

[Sampei]

Liposomal is for pussy ass bitch

 

[gainslol]

Ik many hate ChatGpt, not citing it as a valid source but trying to understand the thought process and Pharmacokinetics.

You ask great questions but I can guarantee to you that ChatGPT is just hallucinating because there simply isn't enough data on your question. Nobody has ever studied specifically for glutathione whether IM or SubQ is better.

And it's also completely wrong unfortunately, and I'll try to explain to you why.

It's best to take a step back and look at what glutathione is. But even before that, look here first: Peptides PK/PD study

Notice the part I put in bold:

The absorption of drugs through subcutaneous and intramuscular injections is highly molecule-dependent. After subcutaneous or intramuscular injection, peptide drugs can enter the systemic circulation through capillaries or lymphatic vessels. As the molecular weight of the drug increases, the proportion of drug absorption through convective transport into the lymphatic system increases. Lymphatic absorption is the primary absorption pathway for therapeutic protein macromolecules. After subcutaneous injection, drugs with a molecular weight below 1 kDa are primarily absorbed by capillaries, while proteins with a molecular weight of 16 - 22 kDa or higher are mainly absorbed through the lymphatic system. The molecular weight of most therapeutic peptides falls between 1 and 10 kDa, and they are generally absorbed through both the lymphatic system and blood vessels, although the extent of absorption through convective transport into the lymphatic system is usually limited. Diffusion into capillaries is the primary absorption mechanism for the majority of peptide drugs

So now take into consideration that glutathione is very small and it's also only 3 amino acids. More specifically it's only 307 daltons. So if you look above to what I pasted, you now know that it's not even 1 kDa.

This means that regardless on whether you're injecting it IM or SubQ, it's going to mostly be rapidly absorbed by the capillaries in your body. This actually goes for most peptides but it's even more so with glutathione because of how small it is. In other words, the difference in absorption is going to be minuscule.

Will it be absorbed faster IM? Sure, but it's really not a big difference (with glutathione that is).

 

[Deadpool99]

You ask great questions but I can guarantee to you that ChatGPT is just hallucinating because there simply isn't enough data on your question. Nobody has ever studied specifically for glutathione whether IM or SubQ is better.

And it's also completely wrong unfortunately, and I'll try to explain to you why.

It's best to take a step back and look at what glutathione is. But even before that, look here first: Peptides PK/PD study

Notice the part I put in bold:


So now take into consideration that glutathione is very small and it's also only 3 amino acids. More specifically it's only 307 daltons. So if you look above to what I pasted, you now know that it's not even 1 kDa.

This means that regardless on whether you're injecting it IM or SubQ, it's going to mostly be rapidly absorbed by the capillaries in your body. This actually goes for most peptides but it's even more so with glutathione because of how small it is. In other words, the difference in absorption is going to be minuscule.

Will it be absorbed faster IM? Sure, but it's really not a big difference (with glutathione that is).

Why I deem myself dumb and ChatGpt pointless, I did 3 deep research with ChatGpt.

However u basically debunked it entirely, took you one post , Kudos to u.
Your analysis debunks the notion that IM is superior for glutathione.
For a 307 Da molecule, IM and SubQ are pharmacokinetically equivalent, so the best route is simply the one you tolerate and can perform consistently.

Thank you <3

 

[Photon]

Why I deem myself dumb and ChatGpt pointless, I did 3 deep research with ChatGpt.

However u basically debunked it entirely, took you one post , Kudos to u.
Your analysis debunks the notion that IM is superior for glutathione.
For a 307 Da molecule, IM and SubQ are pharmacokinetically equivalent, so the best route is simply the one you tolerate and can perform consistently.

Thank you <3

The only reason I switched to IM was because subq at high concentration was leaving behind hard lumps (like candy) which took ages to clear. You'll understand once u start pinning it...its thick

 

[Deadpool99]

Think I'll use 2.3ml bac water to get 400mg/ml and do 1ml Subq and see how it goes.

I think a good time to re-test liver enzymes should be 4 weeks.

 

[Deadpool99]

The only reason I switched to IM was because subq at high concentration was leaving behind hard lumps (like candy) which took ages to clear. You'll understand once u start pinning it...its thick

I used to do 2 injections a day, 1ml (500mg) L-carn subq. Is it any similar?
It was ready to inject, ordered from Researchem at the time

 

[Photon]

I used to do 2 injections a day, 1ml (500mg) L-carn subq.

Alot thicker at same mg/ml