Is ethyl oleate approved for injectable use? Is it safe?

[Erin]

Is ethyl oleate currently approved by the U.S. Food and Drug Administration for injectable use?
Please cite references.

Wikipedia says no (uncited), but links to work by Laposata:
"FAEE were found to uncouple oxidative phosphorylation in isolated mitochondria a and to increase the fragility of isolated pancreatic lysosomes. In addition, studies from our laboratory provided the first demonstration that FAEE in a physiologic particle, low density lipoprotein, can exert a toxic effect on an intact cell. We demonstrated that FAEE within LDL can reduce the rate of replication of HepG2 cells and decrease their rate of protein synthesis. We subsequently demonstrated in vivo that rats receiving FAEE in reconstituted LDL, at FAEE concentrations which are physiologically attainable (10-30 gM) after ethanol ingestion, showed toxicity for pancreatic acinar cells after a single infusion. Taken together, it is now a compelling argument that FAEE contribute to the toxicity of ethanol abuse."

Water-Insoluble Drug Formulation, Second Edition is cited to say yes:

 

[high-octane]

Fuck EO. Pip from hell.

 

[master.on]

Is ethyl oleate currently approved by the U.S. Food and Drug Administration for injectable use?
Please cite references.

Wikipedia says no (uncited), but links to work by Laposata:
"FAEE were found to uncouple oxidative phosphorylation in isolated mitochondria a and to increase the fragility of isolated pancreatic lysosomes. In addition, studies from our laboratory provided the first demonstration that FAEE in a physiologic particle, low density lipoprotein, can exert a toxic effect on an intact cell. We demonstrated that FAEE within LDL can reduce the rate of replication of HepG2 cells and decrease their rate of protein synthesis. We subsequently demonstrated in vivo that rats receiving FAEE in reconstituted LDL, at FAEE concentrations which are physiologically attainable (10-30 gM) after ethanol ingestion, showed toxicity for pancreatic acinar cells after a single infusion. Taken together, it is now a compelling argument that FAEE contribute to the toxicity of ethanol abuse."

Water-Insoluble Drug Formulation, Second Edition is cited to say yes:
View attachment 69697

Ethyl oleate is not currently approved by the U.S. Food and Drug Administration for any injectable use. However, it is used by compounding pharmacies as a vehicle for intramuscular drug delivery, in some cases to prepare the daily doses of progesterone in support of pregnancy. Studies which document the safe use of ethyl oleate in pregnancy for both the mother and the fetus have never been performed.
Ethyl oleate - Wikipedia

"FAEE were found to uncouple oxidative phosphorylation in isolated mitochondria
Aint that the way DNP works?

Why risk it?
MCT instead
It may not increase solubility like EO does,
but MCTs are proven safe.

 

[Den84]

The pharma grade test cyp from spain (testex) contains EO among the excipients.. in eu is approved.

 

[Docd187123]

I've not seen anything that suggests it's approved for injectable use although some compounding pharmacies use it for PRG injections (and there was a FDA investigation into it due to stopper particulate found in the solution).

 

[Den84]

I've not seen anything that suggests it's approved for injectable use although some compounding pharmacies use it for PRG injections (and there was a FDA investigation into it due to stopper particulate found in the solution).

 

[MisterSuperGod]

Damn bro, charge your phone much?
You may need to translate, i'm 100% sure i cannot speak nor read that language... i really tried, too!

 

[Docd187123]

He asked about the US FDA specifically.

 

[Erin]

Damn bro, charge your phone much?
You may need to translate, i'm 100% sure i cannot speak nor read that language... i really tried, too!

Oleato de etilo = Ethyl oleate

 

[Erin]

"FAEE were found to uncouple oxidative phosphorylation in isolated mitochondria
Aint that the way DNP works?

That's exactly the way DNP works. Hopefully we won't have a bunch of guys trying to stack EO with their gear as part of a "cutting cycle".

Why risk it?
MCT instead
It may not increase solubility like EO does,
but MCTs are proven safe.

I agree with this completely. Laposata's early papers would seem to give cause for widespread concern. I'm mostly confused as to why this does not seem to have come to pass.

 

[notanothersnake]

Fuck EO! Id much rather just use Miglyol to achieve thinner gear. Its amazing and none of that bad reaction shit it seems like half the ppl who inject EO get...

 

[XKawN]

Fuck EO! Id much rather just use Miglyol to achieve thinner gear. Its amazing and none of that bad reaction shit it seems like half the ppl who inject EO get...

Actually, it's closer to 2-3 percent.

 

[notanothersnake]

Actually, it's closer to 2-3 percent.

I figured. And it most likely "seems like" so many ppl get reactions because the bad ones are the ones who always talk about it. I'm still a fan of the mig. Cheaper than EO too.

 

[pharmasource]

EO is in pharm grade Testosterone Propionate 50mg too, Farmak , Ukraine ( and must say that this is the best propionate ever , personaly injected 4ml many many times without any problems )

 

[XKawN]

I figured. And it most likely "seems like" so many ppl get reactions because the bad ones are the ones who always talk about it. I'm still a fan of the mig. Cheaper than EO too.

I was on a mission a while back in finding a source of Miglyol 840. Never found one. Is it available anywhere in less than a drum?

 

[cory]

EO is in pharm grade Testosterone Propionate 50mg too, Farmak , Ukraine ( and must say that this is the best propionate ever , personaly injected 4ml many many times without any problems )

I haven't got a reply through email on who to send funds to. Is your email pretty backed up?

 

[XKawN]

No whoring outside sources thread.

 

[Erin]

I was on a mission a while back in finding a source of Miglyol 840. Never found one. Is it available anywhere in less than a drum?

Consider that Miglyol 840 is not approved for injection.

125mL:
Miglyol 840*** 125ml ** Viscocity 9-12, thinner than GSO and MCT, great carrier. | eBay

500mL:
Miglyol 840*** .5L** Viscocity 9-12, thinner than GSO and MCT, great carrier. | eBay

 

[notanothersnake]

I was on a mission a while back in finding a source of Miglyol 840. Never found one. Is it available anywhere in less than a drum?

yeah, me.. seriously...