Is reta over tir good idea?

[Kalinser]

hello, title

 

[GreenGains]

Would like to add my experience with Reta (instead of creating a whole new thread when there's plenty already here). Literally started 2mg Wednesday with the aim of titrating up.

I ran out of tirzepatide maybe 8 weeks ago (7.5.mg/week) and was pretty lean at that point, but had maybe 10 pounds (4.5kg) to go to get to my ideal. Figured I'd just white knuckle it. That did NOT work and went on a pretty heavy binge for the last month or so. Now instead of being 10 pounds down, I am 10 pounds up. WE LIVE AND WE LEARN. But why do I always learn the hard way??? Nipping it in the bud this week and said I'd try Reta instead of Tirz to see. As the studies say its more effective. Tirzepatide worked great for me but if there's something better, why not get that?

Now, I am a fat guy at heart and have been overweight most of my adult life. It is easy for me to eat a lot and it is my go to when I am stressed, and I had a rough day at work yesterday, and even though I wasn't hungry, I stuffed myself. To an uncomfortable level. I woke early this morning - about 4:30, to some mild nausea and a definite feeling of fullness. Is it weird that I think of this as a good thing? I don't want to eat anything! It's a great relief. Hoping now, that I've taught myself a lesson in forcefeeding on GLPs, to get myself back on track.

 

[syuri]

like others here, tirz made me depressed and feel like shit. reta does not. only downside i wake up after 6h on reta and have a hard time sleeping beyond, or its broken after 4am, but then i sleep at 9pm every day

been dealing with the same sleep issues. was there a dose you first noticed it on? or was it always since you’ve been on reta

 

[lamehack]

been dealing with the same sleep issues. was there a dose you first noticed it on? or was it always since you’ve been on reta

always, any fucking dose. i really wanted this to work. not just insomnia but restlessness, i recently stopped my 2mg/week dose, and within 2 weeks slept great. tried this for like the 10th time - maybe 1mg will work. nope. i sleep good till 3 am then its over. can't really relax. this is a permanent done with this for me, even no 100mcg.

 

[syuri]

always, any fucking dose. i really wanted this to work. not just insomnia but restlessness, i recently stopped my 2mg/week dose, and within 2 weeks slept great. tried this for like the 10th time - maybe 1mg will work. nope. i sleep good till 3 am then its over. can't really relax. this is a permanent done with this for me, even no 100mcg.

really!? i had made a post about wanting to swap BECAUSE of the sleep.

i deal with the exact same issue brother. i’m relieved to hear this isn’t only something that happens to me; but also upset you had the same issue too.

started reta and testosterone within the same timeframe, both of which affected my sleep, test makes me feel ready to go with less sleep, reta made me wake up earlier and not be able to go back to sleep. my eyes feel heavy, and if i do fall back asleep it’s the lightest sleep ever. terrible stuff.

which GLP did you swap to? tirz or sema?

 

[lamehack]

really!? i had made a post about wanting to swap BECAUSE of the sleep.

i deal with the exact same issue brother. i’m relieved to hear this isn’t only something that happens to me; but also upset you had the same issue too.

started reta and testosterone within the same timeframe, both of which affected my sleep, test makes me feel ready to go with less sleep, reta made me wake up earlier and not be able to go back to sleep. my eyes feel heavy, and if i do fall back asleep it’s the lightest sleep ever. terrible stuff.

which GLP did you swap to? tirz or sema?

Test did not cause any sleep issues for me, and I am a fairly sensitive guy/light sleeper. I did try Tirz - no sleep issues there. but stopped eventually. sem was hell, felt like dying. i am at something 20% BF (dexa) and need to lose like 20lb. i went from 30 to 20% BF with 0 glps's just tracking. at 20 i thought i will get a bit 'help'. it did not. problem with tirz was that it did not do a whole lot till about 7mg or so, but at that level i felt lethargic and unmotivated. plus my appetite switched from healthy cravings (beef, dairy etc) to sugar cravings. so i am done with glps permanently. back to tracking and doing a meat/fruit approach which worked wonders so far.

 

[Liter O' Test]

ive been on tirz for 3 months, not sure if im just lazy or its the tirz
thinking of switching to reta but on paper tirz is superior for insulin sensitivity

 

[syuri]

ive been on tirz for 3 months, not sure if im just lazy or its the tirz
thinking of switching to reta but on paper tirz is superior for insulin sensitivity

swapping to tirz/sema for insulin sensitivity, reta gave me good energy, too much to sleep

you’ll most likely enjoy it

and most people associate the laziness with the glp, i think half the time it’s due to the damn calorie deficit lol.

 

[Liter O' Test]

swapping to tirz/sema for insulin sensitivity, reta gave me good energy, too much to sleep

you’ll most likely enjoy it

and most people associate the laziness with the glp, i think half the time it’s due to the damn calorie deficit lol.

yeah thats what i thought, im not in a deficient though, i think its
1. brain related
or
2. slow digestion all the time just making me tired
or
3. just being lazy independent of glp.

 

[SlamSumTest]

Reta does have me slightly more wired and messed up my sleep.

I will say, I’ve made a conscious ever to eat ever so slightly more the last few days and it has got a lot better.

This is slowly affirming my theory that side effects are just coming from the steep caloric deficit. Especially when you’re averaging 2-4 lbs lost a week.

I am almost done with my Reta and have some tirz, interested to see the difference

 

[Bulldogge16]

Going through a very strict and aggressive deficit (supported with Reta), but very calculated (everything I eat gets tracked). I’ve been amazed about what I’ve learned about how much the lowered calories can affect, and what they affect.

 

[syuri]

Reta does have me slightly more wired and messed up my sleep.

I will say, I’ve made a conscious ever to eat ever so slightly more the last few days and it has got a lot better.

This is slowly affirming my theory that side effects are just coming from the steep caloric deficit. Especially when you’re averaging 2-4 lbs lost a week.

I am almost done with my Reta and have some tirz, interested to see the difference

eh, in my personal experience, my sleeps been fragmented since the start of reta, even on my maintence and bulk phases unfortunately, glad your sleep improved though

swapping to tirz aswell to see the difference

 

[wp_375]

I cut from the start of April to the middle of September on Reta. It worked, I lost a fuck load of weight, majority of the time it was 4mg/week with a few weeks at 8mg towards the end. Eventually the RHR increase was too much, I was just sitting on the couch at 90bpm and listening to my own heartbeat in my ears while I was sleeping. Also my fasting glucose was like high 90's to low 100's, in part I suspect due to the glucagon effect because I was doing daily cardio and eating less than 75mg of carbs a day most of the time.

I did a couple week washout where I stopped Reta and switched to Tirz. Started at 2.5mg/week for 4 weeks, then switched to 5mg/week which I've been running as a maintenance dose. I noticed I can actually sleep now whereas I slept like dogshit on Reta. My RHR is in the high 60's, low 70's instead of the 90's. My fasting glucose is back into the 80's as well... I will probably stick to Tirz for the foreseeable future even though I still have a 30mg kit of Reta in the freezer. I really can't discern a single negative side of the Tirz, it does reduce appetite at this dose but I can still eat 300g of protein a day without feeling like I'm splitting. I have a random day of fatigue that I can't really explain here and there but nothing consistent.

 

[syuri]

I cut from the start of April to the middle of September on Reta. It worked, I lost a fuck load of weight, majority of the time it was 4mg/week with a few weeks at 8mg towards the end. Eventually the RHR increase was too much, I was just sitting on the couch at 90bpm and listening to my own heartbeat in my ears while I was sleeping. Also my fasting glucose was like high 90's to low 100's, in part I suspect due to the glucagon effect because I was doing daily cardio and eating less than 75mg of carbs a day most of the time.

I did a couple week washout where I stopped Reta and switched to Tirz. Started at 2.5mg/week for 4 weeks, then switched to 5mg/week which I've been running as a maintenance dose. I noticed I can actually sleep now whereas I slept like dogshit on Reta. My RHR is in the high 60's, low 70's instead of the 90's. My fasting glucose is back into the 80's as well... I will probably stick to Tirz for the foreseeable future even though I still have a 30mg kit of Reta in the freezer. I really can't discern a single negative side of the Tirz, it does reduce appetite at this dose but I can still eat 300g of protein a day without feeling like I'm splitting. I have a random day of fatigue that I can't really explain here and there but nothing consistent.

very insightful. my RHR has been fuckin high as hell too. this situation of yours nearly lines up with mine.

can’t wait to try the tirz i ordered, thanks for sharing.

 

[Bulldogge16]

I cut from the start of April to the middle of September on Reta. It worked, I lost a fuck load of weight, majority of the time it was 4mg/week with a few weeks at 8mg towards the end. Eventually the RHR increase was too much, I was just sitting on the couch at 90bpm and listening to my own heartbeat in my ears while I was sleeping. Also my fasting glucose was like high 90's to low 100's, in part I suspect due to the glucagon effect because I was doing daily cardio and eating less than 75mg of carbs a day most of the time.

I did a couple week washout where I stopped Reta and switched to Tirz. Started at 2.5mg/week for 4 weeks, then switched to 5mg/week which I've been running as a maintenance dose. I noticed I can actually sleep now whereas I slept like dogshit on Reta. My RHR is in the high 60's, low 70's instead of the 90's. My fasting glucose is back into the 80's as well... I will probably stick to Tirz for the foreseeable future even though I still have a 30mg kit of Reta in the freezer. I really can't discern a single negative side of the Tirz, it does reduce appetite at this dose but I can still eat 300g of protein a day without feeling like I'm splitting. I have a random day of fatigue that I can't really explain here and there but nothing consistent.

I had similar issues with the RHR. I found that the day after refeed days my RHR would drop. Makes me wonder if the RHR was not more affected by the deficit. At the moment I’m taking 3mg weekly split EOD (never went higher dose). I’m slowly bumping up calories without adjusting dose just yet, and I’m finding my RHR is dropping rather quickly. I never tracked RHR in a caloric deficit before Reta so I’m not sure as to the magnitude of effect. That said, I’m sure that Reta does have a baseline impact on RHR , its just how much does it add vs the caloric defect.

 

[wp_375]

I had similar issues with the RHR. I found that the day after refeed days my RHR would drop. Makes me wonder if the RHR was not more affected by the deficit. At the moment I’m taking 3mg weekly split EOD (never went higher dose). I’m slowly bumping up calories without adjusting dose just yet, and I’m finding my RHR is dropping rather quickly. I never tracked RHR in a caloric deficit before Reta so I’m not sure as to the magnitude of effect. That said, I’m sure that Reta does have a baseline impact on RHR , its just how much does it add vs the caloric defect.

The studies for Reta showed around 3-5bpm increase for the participants IIRC, so I may just be hypersensitive to it. I wasn't on a bunch of gear at the time either, was around 150mg a week total at the low end and 280mg total per week at the high end. Running GH definitely made it even worse at fairly low doses, around 3-4iu a day.

 

[Bulldogge16]

The studies for Reta showed around 3-5bpm increase for the participants IIRC, so I may just be hypersensitive to it. I wasn't on a bunch of gear at the time either, was around 150mg a week total at the low end and 280mg total per week at the high end. Running GH definitely made it even worse at fairly low doses, around 3-4iu a day.

Give yourself a couple of back to back refeed days and and more carbs than normal with some before bed. Make sure your electrolytes/sodium intake are good, possible ashwaghanda. See if that helps. Also keep in mind… elevated RHR (sub 100bpm) within reason and BP still in a healthy range isn’t inherently a big concern. Especially when you know the likely causes. Sympathetic nervous system is also a culprit.
I get it though, it did bother me too. I just kept trying to look at the big picture and monitored BP daily. And it always stayed in a very healthy range so I didn’t get too worried. But we all have our own limits of tolerance.

 

[Luckylefty]

I found appetite suppression is lower with Reta than sema & tirz. A lot less side effects though. The day after a shot with tirz/sema or after a cheat day, I’d get terrible sulfur burps, bloat to the point of not being able to sit up, and huge hit to gym performance. I remember when I first started I couldn’t even drink water and would have to lay down mid-workout due to extreme fatigue and nausea. Never had any similar feeling with Reta other than a rumbling stomach and occasional indigestion.

Grey Reta is getting cheap enough that you can take it + cargi for a similar price you’d get Tirz about a year ago, so you’d have similar hunger suppression plus the benefits of glucagon. Or at least that’s what I’ve found.

 

[syuri]

I found appetite suppression is lower with Reta than sema & tirz. A lot less side effects though. The day after a shot with tirz/sema or after a cheat day, I’d get terrible sulfur burps, bloat to the point of not being able to sit up, and huge hit to gym performance. I remember when I first started I couldn’t even drink water and would have to lay down mid-workout due to extreme fatigue and nausea. Never had any similar feeling with Reta other than a rumbling stomach and occasional indigestion.

Grey Reta is getting cheap enough that you can take it + cargi for a similar price you’d get Tirz about a year ago, so you’d have similar hunger suppression plus the benefits of glucagon. Or at least that’s what I’ve found.

when you took tirz and sema and experienced those issues, were you heavily fatigued? and what dosing did you take of each? thanks

 

[Luckylefty]

when you took tirz and sema and experienced those issues, were you heavily fatigued? and what dosing did you take of each? thanks

I started at standard dosing protocol for each, titrating up. 0.25 a month, .5 a month, etc. I didn’t feel crazily fatigued but overall, but gym performance was impacted. I was also recovering from a neck fracture so it’s hard to know how much that had to play into fatigue and nausea vs. the GLP1, but I’d say the nausea was more impactful than the fatigue

 

[Liter O' Test]

I cut from the start of April to the middle of September on Reta. It worked, I lost a fuck load of weight, majority of the time it was 4mg/week with a few weeks at 8mg towards the end. Eventually the RHR increase was too much, I was just sitting on the couch at 90bpm and listening to my own heartbeat in my ears while I was sleeping. Also my fasting glucose was like high 90's to low 100's, in part I suspect due to the glucagon effect because I was doing daily cardio and eating less than 75mg of carbs a day most of the time.

I did a couple week washout where I stopped Reta and switched to Tirz. Started at 2.5mg/week for 4 weeks, then switched to 5mg/week which I've been running as a maintenance dose. I noticed I can actually sleep now whereas I slept like dogshit on Reta. My RHR is in the high 60's, low 70's instead of the 90's. My fasting glucose is back into the 80's as well... I will probably stick to Tirz for the foreseeable future even though I still have a 30mg kit of Reta in the freezer. I really can't discern a single negative side of the Tirz, it does reduce appetite at this dose but I can still eat 300g of protein a day without feeling like I'm splitting. I have a random day of fatigue that I can't really explain here and there but nothing consistent.

yeah you had double the glucagon effect because low carb diets create glucagon aswell. when I did keto (no glp) my FBG was high 90s in a big deficiet.

thank you for your experience and detail.