Liquid Tesofensine

[Bizzark1]

Hi guys,

I have 1g of tesofensine id like to suspend.

I have a few options on hand:

DMSO
Glycerine
PEG400

Could anyone recommend the best option or combination of?

Many thanks

 

[Nunya]

I’m curious as well, hope somebody chimes in on this!

 

[direrisk]

Following

 

[Musmadar]

Tesofensine is typically used in microgram doses, so precise measurements and solubility are crucial.

A typical tesofensine dose ranges from 0.5 mg to 1 mg/dose:

1 mg/mL: Suitable for direct dosing with a small volume.

 

[direrisk]

Tesofensine is typically used in microgram doses, so precise measurements and solubility are crucial.

A typical tesofensine dose ranges from 0.5 mg to 1 mg/dose:

1 mg/mL: Suitable for direct dosing with a small volume.

Thank you - I'm wondering if there's a best option for suspension, given that in the literature the solubility of tesofensine in DMSO is only 1-2 mg/mL (even with warming and ultrasonic process). Given that, you'd need ~1L of DMSO to dissolve... Would glycerine or peg400 work better? Does anyone have experience with this?

 

[Musmadar]

Thank you - I'm wondering if there's a best option for suspension, given that in the literature the solubility of tesofensine in DMSO is only 1-2 mg/mL (even with warming and ultrasonic process). Given that, you'd need ~1L of DMSO to dissolve... Would glycerine or peg400 work better? Does anyone have experience with this?

After some reading peg400 seems to be the best option:

Warm PEG 400 to 40–50°C, add tesofensine powder while stirring continuously, slowly mix in ethanol (15-20%) , gradually add distilled water or propylene glycol while stirring to reach the desired final volume, add a small amount of glycerin for sweetness or a non-sugar sweetener like sucralose.

If necessary, filter the solution through a 0.22-micron filter for sterility purpose.

These are recommendations based on different sources, I haven't try it, just yet.

 

[direrisk]

Thanks for your response! I'm thinking I might try it out, however the smallest amount of teso I can obtain is 1 gram (about 6 years worth of what I need). I don't think it would last that long....

 

[Musmadar]

Good Luck, don't forget to post with results.

 

[narta]

Don't. If you get the dosing wrong you will have a nasty ride

 

[direrisk]

Don't. If you get the dosing wrong you will have a nasty ride

Thanks for the warning - I am a trained chemist and understand the risks.

 

[Musmadar]

Narta is right: the biggest of issues in this project is to make the exact measurements of Teso....

 

[narta]

Thanks for the warning - I am a trained chemist and understand the risks.

Keep us updated if you manage to make a suitable recipe for suspending it

 

[direrisk]

If you don't hear from me I made an error lol