Lose Dose Tirz for Binge Eating

12468jma

New Member
Edit: Title should say Lowest* not Lose

I searched and found a lot of questions as to maximum dosages on GLPs for maintenance but found limited info on lowest doses possible. Apologies in advance for wordiness.

In my case, I am about 5'5 and started at 160#, female. Grey market tirz at 2.5mg once a week kicked my ass and successfully reached my pre-COVID weight of 130# in a span of <4 months. This body weight is where my body tends to feel "good" and healthy. There was never a need to increase dose as it seemed I was super responsive to the lowest recommended dose but I did stop taking it and maintained w/o for about 6 months.

After discontinuing the GLP I was able to keep all the mental benefits of lessened food noise but only so long as I kept eating clean and healthy. Then came my self-afflicted THC dependency. Started smoking heavily and caved into the severe munchies, for me when I expose my body to junk food I then NEED more and can.not.stop. Food noise? Back with a fucking vengeance. I got up to maybe 140# by the time I realized, so only 10 lbs but on my small frame it's easily noticed with joint pain and swelling.

I decided I needed to nip it but remembered how strong the effects were on 2.5. I lowered my dose to 1-1.5mg Tirz and that was perfect. That unbearable food noise was once again completely gone. I have gone back to eating majority of homecooked meals and avoiding junk/sugary food. Did not repeat injection. That was about a month ago, still feeling the lack of food noise.

My concern NOW is that in my searches I saw Ghoul mentioned that we can develop issues when we start and stop these meds as they are meant for continuous use. Now I'm concerned I'm setting myself up for failure in the future due to my clear misuse of this medication.

Would it be best to continue on a very low dose once a week to continue the exposure and avoid resistance? In my case it's more to control my tendency to binge eat. On 2.5mg, I absolutely could not eat much more than a cup of food per meal and long term I would not be getting enough nutrients, as my nails were starting to get weak. In my not smart brain, I'm thinking I can begin to do weekly injections at 1mg indefinitely so long as my food noise is eliminated and I can get enough nutrients by eating appropriately sized meals.

Please advise.

GG
 
Edit: Title should say Lowest* not Lose

I searched and found a lot of questions as to maximum dosages on GLPs for maintenance but found limited info on lowest doses possible. Apologies in advance for wordiness.

In my case, I am about 5'5 and started at 160#, female. Grey market tirz at 2.5mg once a week kicked my ass and successfully reached my pre-COVID weight of 130# in a span of <4 months. This body weight is where my body tends to feel "good" and healthy. There was never a need to increase dose as it seemed I was super responsive to the lowest recommended dose but I did stop taking it and maintained w/o for about 6 months.

After discontinuing the GLP I was able to keep all the mental benefits of lessened food noise but only so long as I kept eating clean and healthy. Then came my self-afflicted THC dependency. Started smoking heavily and caved into the severe munchies, for me when I expose my body to junk food I then NEED more and can.not.stop. Food noise? Back with a fucking vengeance. I got up to maybe 140# by the time I realized, so only 10 lbs but on my small frame it's easily noticed with joint pain and swelling.

I decided I needed to nip it but remembered how strong the effects were on 2.5. I lowered my dose to 1-1.5mg Tirz and that was perfect. That unbearable food noise was once again completely gone. I have gone back to eating majority of homecooked meals and avoiding junk/sugary food. Did not repeat injection. That was about a month ago, still feeling the lack of food noise.

My concern NOW is that in my searches I saw Ghoul mentioned that we can develop issues when we start and stop these meds as they are meant for continuous use. Now I'm concerned I'm setting myself up for failure in the future due to my clear misuse of this medication.

Would it be best to continue on a very low dose once a week to continue the exposure and avoid resistance? In my case it's more to control my tendency to binge eat. On 2.5mg, I absolutely could not eat much more than a cup of food per meal and long term I would not be getting enough nutrients, as my nails were starting to get weak. In my not smart brain, I'm thinking I can begin to do weekly injections at 1mg indefinitely so long as my food noise is eliminated and I can get enough nutrients by eating appropriately sized meals.

Please advise.

GG

There's no minimum. If you can find a dose that works for you, staying at that level is fine.

It's an intersting, obscure topic, because there are cases where too little exposure to a protein therapeutic drug can, paradoxically, create immunogenicity while high exposure "normalizes" the immune system to its presence.

This was thought to be the case with Sema and Tirz, which both required reaching certain high "maintainance" doses within 6 months or treatment was supposed to be stopped,

It turned out with more data this wasn't a concern with these compounds so pharma changed the guidance, and staying on any dose as long as it works is acceptable,

It'll also, at the least, give you improved insulin sensitiyivity, and likely other long term health benefits.
 
There's no minimum. If you can find a dose that works for you, staying at that level is fine.

It's an intersting, obscure topic, because there are cases where too little exposure to a protein therapeutic drug can, paradoxically, create immunogenicity while high exposure "normalizes" the immune system to its presence.

This was thought to be the case with Sema and Tirz, which both required reaching certain high "maintainance" doses within 6 months or treatment was supposed to be stopped,

It turned out with more data this wasn't a concern with these compounds so pharma changed the guidance, and staying on any dose as long as it works is acceptable,

It'll also, at the least, give you improved insulin sensitiyivity, and likely other long term health benefits.
I appreciate you taking the time to answer my question and I thank you!
 
I can say from my own experience that you develop tolerance to it with continious use eventually. 15mg reta stopped doing anything for me pretty much. I'm sure it would work properly again after giving my body a break for a few months. That's also what I've seen other people report.
 
Grey market tirz at 2.5mg once a week kicked my ass and successfully reached my pre-COVID weight of 130# in a span of <4 months. This body weight is where my body tends to feel "good" and healthy. There was never a need to increase dose as it seemed I was super responsive to the lowest recommended dose but I did stop taking it and maintained w/o for about 6 months.


THC dependency. Started smoking heavily and caved into the severe munchies, for me when I expose my body to junk food I then NEED more and can.not.stop. Food noise? Back with a fucking vengeance.


Please advise.

Seems you answered your own question here...

Captain obvious here, but the logical solution seems you need to stop smoking dope.

If something is having a dramatic negative effect on your health perhaps that is the problem you need to address.

taking one medication to counter the effects of another...

"The greatest medicine of all is teaching people how not to need it"
 
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I can say from my own experience that you develop tolerance to it with continious use eventually. 15mg reta stopped doing anything for me pretty much. I'm sure it would work properly again after giving my body a break for a few months. That's also what I've seen other people report.

When you say "tolerance", do you mean 15mg stopped working and you've been regaining weight?
 
Seems you answered your own question here...

Captain obvious here, but the logical solution seems you need to stop smoking dope.

If something is having a dramatic negative effect on your health perhaps that is the problem you need to address.
Oh absolutely! It was the kick in the pants I needed. I "thought" I was relaxing but really I was being avoidant of my responsibilities, goals and was eating myself to sleep. In the moment it's very very easy to make excuses. Hello addiction, it's me. Re-triggered my food addiction with excessive THC use.

To answer @bigMoJo, after that injection I started being able to come home from work and actually say nah I'm good. I would say it has a very noticeable effect on my desire to use substances.

In the last month I have reduced my usage from multiple bowls and joints a day to a single evening bowl which doesn't trigger my binge eating AND I can take it or leave it. I do not want to quit THC as it has been a major contributor to helping my CPTSD but I also don't want to abuse it.
 
Oh absolutely! It was the kick in the pants I needed. I "thought" I was relaxing but really I was being avoidant of my responsibilities, goals and was eating myself to sleep. In the moment it's very very easy to make excuses. Hello addiction, it's me. Re-triggered my food addiction with excessive THC use.

To answer @bigMoJo, after that injection I started being able to come home from work and actually say nah I'm good. I would say it has a very noticeable effect on my desire to use substances.

In the last month I have reduced my usage from multiple bowls and joints a day to a single evening bowl which doesn't trigger my binge eating AND I can take it or leave it. I do not want to quit THC as it has been a major contributor to helping my CPTSD but I also don't want to abuse it.
you consider edibles to really dial in your thc dosage? as opposed to smoking it. probably a healthier option also.
 
you consider edibles to really dial in your thc dosage? as opposed to smoking it. probably a healthier option also.
You're not wrong, it would be beneficial to know exactly how many mgs I actually require to get the stillness of mind I'm looking for. Tried my hand at AVB baked goods once and ofc I was baking stoned so that was a dud. Deliciously dank flavored duds though. Using distillate to create the edibles will be the next step.

The goal is to use it as a tool to allow my body to process my shit, thank it profusely and leave it behind. I just cannot allow myself to abuse it again. I appreciate the advice!
 
You're not wrong, it would be beneficial to know exactly how many mgs I actually require to get the stillness of mind I'm looking for. Tried my hand at AVB baked goods once and ofc I was baking stoned so that was a dud. Deliciously dank flavored duds though. Using distillate to create the edibles will be the next step.

The goal is to use it as a tool to allow my body to process my shit, thank it profusely and leave it behind. I just cannot allow myself to abuse it again. I appreciate the advice!
easy to make overpowering baked goods that will ruin your life after one bite. Made a batch using a couple kgs of outdoor that were devastating.

Things have come a long way with distillates where you can walk into a store and buy some gummies with the exact dosing. the ones I've seen are quite weak but perhaps that is all thats needed.
 
When you say "tolerance", do you mean 15mg stopped working and you've been regaining weight?
I was only talking about appetite suppression. I don't feel it anymore. I could stuff my face (and gain weight) if I didn't follow a diet. The urge is there. I forgot I needed to eat and drink when I first started it.
 
I used to enjoy smoking Marijuana now later in life it causes me extreme paranoia. It comes with many negative side effects and may be difficult to give up but it's worth trying.
from my experience, i was long time smoker woth stupid high tolerance. i could smoke 5-7g per evening alone and could function in life high all the time without issues. it was never strong for me, even edibles, but i always needed much more of everything than other people.

one day, i found out it wasnt pleasent feeling anymore. no negative feelings appeared but positives disappeared. stopped cold turkey without any cravings etc. weird.

but i know many people that have simillar experieces as you describe, basicly from daily smoker to anxiety/paranoia/unoleasent experience.
 
from my experience, i was long time smoker woth stupid high tolerance. i could smoke 5-7g per evening alone and could function in life high all the time without issues. it was never strong for me, even edibles, but i always needed much more of everything than other people.

one day, i found out it wasnt pleasent feeling anymore. no negative feelings appeared but positives disappeared. stopped cold turkey without any cravings etc. weird.

but i know many people that have simillar experieces as you describe, basicly from daily smoker to anxiety/paranoia/unoleasent experience.

I believe for these kind of things there is currently a combination of Tirza and PT141 in trial.
 
easy to make overpowering baked goods that will ruin your life after one bite. Made a batch using a couple kgs of outdoor that were devastating.

Things have come a long way with distillates where you can walk into a store and buy some gummies with the exact dosing. the ones I've seen are quite weak but perhaps that is all thats needed.
reminds me of my killer butter. 100g of indoor topbuds with 100g of butter, had to use load of water with it during cooking.

after it was done, my house smelled like weed for week and everybody was scared to try it, until friend came with heroic attitude "im immune to it"... well, after one toast he wasnt. called me 3 days later...

dosing was interesting, basicly piece smaller than nail on pinky was enough for 24h. i still have plenty of it in freezer...
 
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