nope you just take it whenever.. same with Viagra... heres the deal with that... a few years back women started experimenting with Viagra.. they did some studies on it and found that some.. not all women have increased sexual benefits after taking Viagra... increased blood flow to the clit.. increased arousal... ect.... but some women don't like Viagra for the same reason men don't... the sides..... stuffed up nose, headache, blurry vision.... it makes me feel like I cant breath through my nose.. so I tried Cialis.. same concept but Cialis is more mild ... like a longer ester testosterone.. Viagra is intense but lasts 4 hours.. Cialis is more mild and lasts up to 36 hours... hope this helps...