MESO "Specialized" Testing Group Fund

[readalot]

Yes but my comment was specific to site reactions caused by HGH not the bac water used or the BA it contains.

I've read the clinical dosing guidelines from the endocrinologist society and there is no mention of immunogenicity testing.

Unless there is a sub standard response in terms of IGF1 levels they wouldn't bother testing for immunogenicity unless there was a site or systemic immune response and BA was eliminated as the cause.

So my point is from a practical perspective the aggregates and the immune response they cause will generally be a site response and in rare cases a systemic reaction.

If the HGH molecule is misfolded it won't trigger an increase in IGF1.

That's why I recommended testing for non neutralising and neutralising antibodies. Unless I'm missing something that in combination with purity and contaminate testing should be sufficient...

I've definitely had a systemic itch with one "generic" I used without any site specific reaction.

I'd imagine host cell proteins also need to be considered.

 

[readalot]

Yes but my comment was specific to site reactions caused by HGH not the bac water used or the BA it contains.

I've read the clinical dosing guidelines from the endocrinologist society and there is no mention of immunogenicity testing.

Unless there is a sub standard response in terms of IGF1 levels they wouldn't bother testing for immunogenicity unless there was a site or systemic immune response and BA was eliminated as the cause.

So my point is from a practical perspective the aggregates and the immune response they cause will generally be a site response and in rare cases a systemic reaction.

If the HGH molecule is misfolded it won't trigger an increase in IGF1.

That's why I recommended testing for non neutralising and neutralising antibodies. Unless I'm missing something that in combination with purity and contaminate testing should be sufficient...

I believe we had narrowed potential testing to bioactivity, CD and/or NMR. I will keep mumbling about HCPs until I find a way to evaluate them or just get bored.

 

[bananafeet]

I believe we had narrowed potential testing to bioactivity, CD and/or NMR. I will keep mumbling about HCPs until I find a way to evaluate them or just get bored.

Ok sounds good. I have no idea what any of that means but I'll have a read into it.

I'm currently trying to distract myself with another hobby as this one is giving me anxiety

Seems like we are closer to a consensus.

 

[readalot]

Ok sounds good. I have no idea what any of that means but I'll have a read into it.

I'm currently trying to distract myself with another hobby as this one is giving me anxiety

Seems like we are closer to a consensus.

Go back through the above posts if interested. I basically lost interest / got a little demoralized when many put money in (at least offered) but there was one obvious person missing even after many invites. I probably took it too hard. I will be ok in time.

I have some tren e here and tren a coming. That may help.

 

[Ateam2023]

Go back through the above posts if interested. I basically lost interest / got a little demoralized when many put money in (at least offered) but there was one obvious person missing even after many invites. I probably took it too hard. I will be ok in time.

I have some tren e here and tren a coming. That may help.

Not the "upcoming Tren Train" #@readalot ,,

 

[BamaCrazy]

Go back through the above posts if interested. I basically lost interest / got a little demoralized when many put money in (at least offered) but there was one obvious person missing even after many invites. I probably took it too hard. I will be ok in time.

I have some tren e here and tren a coming. That may help.

I think you are going to love Tren A. I expected Mast to be a mood booster but it never really had that effect. But Tren does. And I’m sleeping better, not worse. Very unexpected benefits.

 

[readalot]

I think you are going to love Tren A. I expected Mast to be a mood booster but it never really had that effect. But Tren does. And I’m sleeping better, not worse. Very unexpected benefits.

I am thinking 5 or 10 mg/day Tren A on top of 100 mg/week Test Cyp (plain TRT). Always wanted to try 'TTRT". Thanks for sharing your experience.

Mast didn't cut it. Great gainz to the prostate though.

 

[readalot]

Not the "upcoming Tren Train" #@readalot ,,

 

[Spaceman Spiff]

I think you are going to love Tren A. I expected Mast to be a mood booster but it never really had that effect. But Tren does. And I’m sleeping better, not worse. Very unexpected benefits.

Been running Tren H for a few weeks. super impressed with the mental stability(for the most part).

250mg a week.

 

[BamaCrazy]

Been running Tren H for a few weeks. super impressed with the mental stability(for the most part).

250mg a week.

Have you used Tren A also and how do the two compare?

 

[cajunpauper]

I am thinking 5 or 10 mg/day Tren A on top of 100 mg/week Test Cyp (plain TRT). Always wanted to try 'TTRT". Thanks for sharing your experience.

Mast didn't cut it. Great gainz to the prostate though.

I've never heard of TTRT but I'm all about it.

 

[Spaceman Spiff]

Guess it's crickets up in this shit.

Let's test bioactivity from IGF testing, jano results, and responses.

More practical measurements. Kind of like, " did the weed make you high?"

 

[readalot]

Guess it's crickets up in this shit.

Let's test bioactivity from IGF testing, jano results, and responses.

More practical measurements. Kind of like, " did the weed make you high?"

I'm down. Working up my courage to inject 10 IU GH in one go and do serum GH. That's probably best bet given all the IGF-1 variability. I will cease my ramblings on imposter GH until I have a means of checking it. And I have no idea about the GH IA interference question if indeed the GH wasn't bioactive.

TLDR: you're right. I got disillusioned and have moved on to thinking about clear, colorless tren and its potential vs incumbent orange stuff.

 

[Ateam2023]

clear tren? i must have missed this, these are my tren vials, the vial on the right is 400 mg/ml tren e, all the others are 100 mg/ml tren a,,

 

[readalot]

clear tren?

One can dream...

R

Post in thread 'Tren . . . the nectar of the gods'

Aug 5, 2025

So bumping this. There may be a better thread. If there is let me know.

Anyone gone down the rabbit hole of tren color and the oxidation chemistry upon heating tren raws in oil with O2 headspace? @Type-IIx?

The chemistry is pretty straight forward with conjugated C-C double bonds (I will spare the numbering) reacting to form quinones which are known chromophores.

The rub is these benzoquinone tren derivatives are decently studied in cancer research for their ability to increase ROS and speed up cell death. So my hypothesis is that when you run darkly colored tren you are...

• readalot

• 

Would be cool side by side comparison of reported sides. Love to hear your thoughts.

 

[Ateam2023]

I'm down. Working up my courage to inject 10 IU GH in one go and do serum GH. That's probably best bet given all the IGF-1 variability. I will cease my ramblings on imposter GH until I have a means of checking it. And I have no idea about the GH IA interference question if indeed the GH wasn't bioactive.

TLDR: you're right. I got disillusioned and have moved on to thinking about clear, colorless tren and its potential vs incumbent orange stuff.

i have a gh serum test tomorrow morning, so it will be 1 vial (10 iu) of @TheLobster hgh orange top, , stay tuned

 

[Ateam2023]

One can dream...

R

Post in thread 'Tren . . . the nectar of the gods'

Aug 5, 2025

So bumping this. There may be a better thread. If there is let me know.

Anyone gone down the rabbit hole of tren color and the oxidation chemistry upon heating tren raws in oil with O2 headspace? @Type-IIx?

The chemistry is pretty straight forward with conjugated C-C double bonds (I will spare the numbering) reacting to form quinones which are known chromophores.

The rub is these benzoquinone tren derivatives are decently studied in cancer research for their ability to increase ROS and speed up cell death. So my hypothesis is that when you run darkly colored tren you are...

• readalot

• 

Would be cool side by side comparison of reported sides. Love to hear your thoughts.

i can't handle the tren , even at @75 mg tren a week, i get road rage when i drive, i havent tried running Masteron with it as Mast seems to help me personally with 19 nor sides from npp, (npp blues) so tbd if i will try tren again, with the Mast,,

 

[readalot]

i can't handle the tren , even at @75 mg tren a week, i get road rage when i drive, i havent tried running Masteron with it as Mast seems to help me personally with 19 nor sides from npp, (npp blues) so tbd if i will try tren again, with the Mast,,

But could you handle 75 mg/wk of colorless tren. Colored "tren" ain't just tren.

Could we decouple some of the negative sides from positive anabolic effects by brewing the quality tren raws in a non-oxidizing environment?

Best color achievable in N2 environment with right antioxidant package? A new age of tren injectables? Probably some iterations with Janoshik as well looking at quinone reactive impurities.

He has shown more color does give more impurity peaks, obviously. Can we correlate low color with better outcomes?

 

[Ateam2023]

But could you handle 75 mg/wk of colorless tren. Colored "tren" ain't just tren.

Could we decouple some of the negative sides from positive anabolic effects by brewing the quality tren raws in a non-oxidizing environment?

Best color achievable in N2 environment with right antioxidant package? A new age of tren injectables? Probably some iterations with Janoshik as well looking at quinone reactive impurities.

He has shown more color does give more impurity peaks, obviously. Can we correlate low color with better outcomes?

so you think its in the raw impurities, and not necessarily the brew method/carrier oil , as that would make sense to me , im unfamiliar with tren really, and really at this age in my life i don't really think its what im really after, ,

 

[readalot]

so you think its in the raw impurities, and not necessarily the brew method/carrier oil , as that would make sense to me , im unfamiliar with tren really, and really at this age in my life i don't really think its what im really after, ,

my argument above was oxidation impurities created during the "brewing" of raws with oil. We could test that hypothesis using right brewing method. No oxygen around. Should yield much better color. Does it matter? The chemistry seems to say yes. Practically speaking in terms of sides? IDK.