Methylene Blue. What do you guys think of it?

[Luke391]

I bought a vial off amazon and started taking 5mg just 5 days ago and the change is amazing. I am mentally much more lucid and quick thinking and my brainfog is almost completely gone. Only thing is my piss is blue. Like a bright blue colour, especially in the morning.
Do you guys have excperience with it? Do you have to "cycle off" every once in a while to resensitise to it or is it bs and I can just stay on it forever? Are there any long term side effects I should worry about? Most of the articles I find are about IV administration of methylene blue, not oral, and at much much higher doses than 5-10mg a day. They report pretty nasty side effects but again, I don't think 2mg/kg of bodyweight IV is comparable to 5-10mg orally.
Should I worry about possible long term problems or can I just enjoy the benefits without a care?

Also, is it true that mixing it with Vitamin C and DMSO makes it more bio-aviable and a stronger anti-oxidant? I found studies that should the synergy between Methylene Blue and vitamin C or DMSO but none that actually show the effects of these toghether in humans.

 

[BigTomJ]

this is a supplement that I have recently started to look into more detail on.

Id be interested to hear any input as well

 

[narta]

this is a supplement that I have recently started to look into more detail on.

Id be interested to hear any input as well

Second that. Found some raw powder locally for like a lifetime supply on 10mg/day for cheap

 

[BigTomJ]

Second that. Found some raw powder locally for like a lifetime supply on 10mg/day for cheap

any knowledge you collected on the stuff yet?
I only first heard about it in the last year, havent heard or seen much on it at all but it sounds super beneficial

 

[29trt]

Have been taking between 2 and 6mgper day for a month..... No effects whatsoever except my pee is blue.... Also i mix it with 1g of vit c per 2mg met blue.
I will keep taking it for other reasons apart from the somewhat bs claims of that snowflake Vig steve.

 

[narta]

any knowledge you collected on the stuff yet?
I only first heard about it in the last year, havent heard or seen much on it at all but it sounds super beneficial

Theoretically it's a cognitive and mitochondria enchancer. Not really deep dived into it, I know it was used for acute toxicity in the past. I recently came across a local chem company that has it for peanuts and considering to give it a go

 

[AlexDavis43]

I've messed around with MB on-and-off for around a decade.

Hoping maybe to preserve cognitive function in aging.

I've read people taking it around alcohol consumption - no idea how it works but alcohol messes with redox balance (NAD+ or something) which contributes to neurotoxicity.

Could be related to NADH.

Seems like a low risk compound, so either it does nothing other than turn your pee blue, or possibly beneficial.

 

[AlexDavis43]

Dosing note: methylene blue stains the shit out of everything. When it's used in your body, it turns clear. So you find the dose that makes your pee blue, then take a little less.

Blue pee isn't harmful or an indication of harm, it just means your taking more than your body can use so you excrete the rest unmetabolized in urine.

*this is all in theory

 

[juicebro]

Didn't do anything for me. Then again I don't feel any of the mitochondria drugs and peptides either no matter the dosage.

 

[AlexDavis43]

Didn't do anything for me. Then again I don't feel any of the mitochondria drugs and peptides either no matter the dosage.

Youtubers say you're supposed to feel a lot of things, but I don't think that's how this compound works.

 

[bigMoJo]

Didn't do anything for me. Then again I don't feel any of the mitochondria drugs and peptides either no matter the dosage.

Youtubers say you're supposed to feel a lot of things, but I don't think that's how this compound works.

For me, I do "feel" some of the peptides I've used...
- Glutathione - aside the control of liver values with toxic orals, I get a feeling of euphoria.
- BPC+TB combo - My knees have noticeable decrease in swelling... especially my right knee. Both knees have had multiple surgeries in the past, including ACL recon for both... Partial meniscus in left, no meniscus in right (its bone on bone). My right knee swells so much, can't see the quad separate from the knee. With BPC/TB, that swelling has subsided enough to where I can. Same effect as with strong anti-inflammatory meds like Prednisone. When using antis together with BPC/TB, swelling completely clears up. But, that's short lived because I don't play with those for more than a day or two. To give you an idea about that swelling, my ortho used to aspirate between 120 to 150cc from my right knee. 120 because he only has two 60cc syringes, 150 was the last time he had three.

Havn't tried any of the mitochondria peptides yet, but interested. I still have to start on other peptides I picked up... NAD+, MT2, and Epithalon (which I understand to have some sort of mitochondrial repair function).

 

[undersc0re]

I have used it a bit in the last couple months, 10 to 15 drops every 2 days seems to do me good, it can give me itchy armpits for some reason and also seems to give me erections a lot at night . Have not noticed much else.

 

[roofer22]

I know you're not supposed to take it with SSRI's which I don't take. I do take Wellbutrin and something else which has me concerned about interactions. I'd really like to give MB a try though.

 

[NewGuy756]

I've been wanting to try this at some point. I'm wondering how people figured out that it's some sort of nootropic.

I hear really 'loud' people saying it's the bees knees. and even more people in the comments saying it does nothing.

 

[Luke391]

I've been wanting to try this at some point. I'm wondering how people figured out that it's some sort of nootropic.

I hear really 'loud' people saying it's the bees knees. and even more people in the comments saying it does nothing.

I have been taking 5mg a day for 2 months at this point, I'd say that it does work. 5mg is not that much so you'd probably see more of a cognitive effect with 10-20mg, but I'm using it more for the long term health benefits for brain health and lowering oxidative stress.
I found that doses up to 0.5mg/kg of bw should be safe for long term use, and a minimum effects dose would be 0.08mg/kg, which is what I use.
At first a noticed a pretty significat cognitive boost, after a while I tought I didn't feel it anymore so I came off and I felt much less lucid and focused. It was just that I got used to being more mentally sharp that I forgot how I felt before. So I'd say it's worth it.

There are many studies of methylene blue on people with different neurodegenerative conditions (alzhaimer, parkinson, strokes, etc) and it always shows positive effects on brain health and cognition.

Negative effects, such as increased oxidative stress and possible liver damage, start to show @ doses of 2mg/kg (which is very high, nobody using it for cognitive enhanchment is using this much) and it is acutely toxic at 7mg/kg (again, nobody is recreationally using this much).
Also these studies are with IV infusion, so with oral methylene blue the tolerable dose/ minimum effective dose is probably higher.

 

[Luke391]

I know you're not supposed to take it with SSRI's which I don't take. I do take Wellbutrin and something else which has me concerned about interactions. I'd really like to give MB a try though.

I'd really think you should not mix it with SSRIs, seratonin syndrome is a serious thing. Messing with your body with Steroids and peptides is one thing, messing with your brain chemistry can be much more dangerous. I have really been liking MB so far and if you wanna try it please do it after coming off welbutrin

 

[Luke391]

Didn't do anything for me. Then again I don't feel any of the mitochondria drugs and peptides either no matter the dosage.

probably because you might already have good mithocondrial efficiency. Mithocondrial supps and peptides usually work best for people with some kind of mithocondrial disfunction, I got a pretty decent boost with Methyleme Blue + NAC + Taurine. Planning to start L-Carnitine and Mot-C in the next few months, as well as NAD+ for glutathione production.

 

[aljowa]

I know you're not supposed to take it with SSRI's which I don't take. I do take Wellbutrin and something else which has me concerned about interactions. I'd really like to give MB a try though.

According to Mayo Clinic (Methylene blue (intravenous route)) and Drugs.com (Methylene blue and Wellbutrin Interactions - Drugs.com), it is advised to not mix bupropion with Methylene Blue. I personally do, with no issues, but I'd still recommend against it in the name of harm-reduction.

I'd really think you should not mix it with SSRIs, seratonin syndrome is a serious thing. Messing with your body with Steroids and peptides is one thing, messing with your brain chemistry can be much more dangerous. I have really been liking MB so far and if you wanna try it please do it after coming off welbutrin

I'm not endorsing mixing Methylene Blue with bupropion, but just for the record, bupropion is not an SSRI, it's an NDRI (norepinephrine–dopamine reuptake inhibitor). Different class of drugs. Your warning is still warranted, though.

 

[Luke391]

According to Mayo Clinic (Methylene blue (intravenous route)) and Drugs.com (Methylene blue and Wellbutrin Interactions - Drugs.com), it is advised to not mix bupropion with Methylene Blue. I personally do, with no issues, but I'd still recommend against it in the name of harm-reduction.



I'm not endorsing mixing Methylene Blue with bupropion, but just for the record, bupropion is not an SSRI, it's an NDRI (norepinephrine–dopamine reuptake inhibitor). Different class of drugs. Your warning is still warranted, though.

exactly, bupropion is a NDRI, MB with these is fine, SSRIs are the issue.
Methylene Blue increase baseline Seratonin production, so an increased seratonin production + an hypersensitivity of the seratonin receptors from the SSRI is just asking for Seratonin Syndrome, which can be harfull to your brain and body at best, and fatal at worst.

Id you wanna mix these two try at your own risk and stick to low doses (2.5-10mg of MB max and a lower-end dose of the SSRI you are on)

 

[fw190jd]

I've been doing it now for a couple of weeks I've had no issues actually I find it Pleasant my cognitive function is better if I had to say anything off the get go. So far I like it very much, I feel like I can think clearer a little bit like living in HD