thinking about giving a try. my right bicep is still lagging a bit from the nerve damage 9 months ago. anyone use this before? if so what was the dosage/protocol
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MGF
- Thread starter flexx89
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Yes I have. I didn't notice to much of a difference cause my muscles were full from the gear I was running. I think if your off cycle you may have better results. That's just my option tho. I would load up a slin pin (31g) and bring it to the gym. It's important to pin while muscles are still pumped cause the half life is very short. Within 15 mins if I remember correct. I pinned 100-150 mcgs bi lateral using micro injections into the muscle I trained. I've read that you may be better off using a pegylated mgf just cause it increases the half life so much more. Good luck
Worthless!
Scientists want to learn about the inner workings of the natural world; as biomedical research scientists, our goals are to understand the mechanisms that regulate normal human physiology, to discern how things may go awry in disease, and to devise effective and specific treatments. When a potential new discovery is made that may facilitate achieving these objectives, it is an admittedly natural tendency to favor the supporting information and dismiss confounding or contradictory data. This psychological phenomenon is termed confirmation bias (1) and is implicit in attempts to prove rather than test hypotheses. The saga of the mechanogrowth factor (MGF) is instructive because it illustrates the dangers of confirmation bias.
...
What can we learn from these admittedly negative data and from the entire MGF story? First, as scientists we must fight against confirmation bias. In the case of MGF, it appears that confirmation bias was evident in the initial idea that correlation (increase in mRNA levels after muscle injury) was equivalent to causation (biological effects of endogenous MGF peptide on satellite cell proliferation) when this had not been established. Second, independently performed follow-up studies are critically needed to confirm or refute novel observations and the resultant hypotheses, and the scientific literature needs to provide a forum for publication of such studies. And third, as acknowledged by the title of this editorial, the last word about MGF has not been written yet. We should maintain an open mind and a healthy skepticism about the possibility that a peptide exists with the postulated biological properties of MGF and as a scientific community demand experiments that critically and objectively test the MGF hypothesis. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896639/
Scientists want to learn about the inner workings of the natural world; as biomedical research scientists, our goals are to understand the mechanisms that regulate normal human physiology, to discern how things may go awry in disease, and to devise effective and specific treatments. When a potential new discovery is made that may facilitate achieving these objectives, it is an admittedly natural tendency to favor the supporting information and dismiss confounding or contradictory data. This psychological phenomenon is termed confirmation bias (1) and is implicit in attempts to prove rather than test hypotheses. The saga of the mechanogrowth factor (MGF) is instructive because it illustrates the dangers of confirmation bias.
...
What can we learn from these admittedly negative data and from the entire MGF story? First, as scientists we must fight against confirmation bias. In the case of MGF, it appears that confirmation bias was evident in the initial idea that correlation (increase in mRNA levels after muscle injury) was equivalent to causation (biological effects of endogenous MGF peptide on satellite cell proliferation) when this had not been established. Second, independently performed follow-up studies are critically needed to confirm or refute novel observations and the resultant hypotheses, and the scientific literature needs to provide a forum for publication of such studies. And third, as acknowledged by the title of this editorial, the last word about MGF has not been written yet. We should maintain an open mind and a healthy skepticism about the possibility that a peptide exists with the postulated biological properties of MGF and as a scientific community demand experiments that critically and objectively test the MGF hypothesis. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896639/
@Michael Scally MD do you have any recommendations or suggestions? I slept on my arm and woke up unable to move it for about 6 weeks. rehab was 6 weeks so after 12 i was pretty functional again. its now been 9 months - the strength is back, but the right bicep and delt arent as full and the shoulder is lacking the striations my left one has.
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