Nad+ vs NMN oral

[Nflz63]

What’s up guys,

Trying to figure out if injectable NAD+ is actually on another level compared to oral NMN, or if it’s mostly hype.

I get that NAD+ shots go straight in and skip digestion, so in theory it should hit harder. But NMN is supposed to convert into NAD+ anyway if you dose it right.

For those who’ve run both:

Did you notice a REAL difference in things like:

• daily energy
• mental sharpness / focus
• recovery from training
• overall “feel younger” / anti-aging type benefits

Or is injectable NAD+ just a more expensive, more complicated way to get similar results to high-dose NMN?

Also curious about:

• what doses you used (both NAD+ and NMN)
• how long you stayed on each
• was the difference obvious or pretty subtle?

Not looking for theory — more interested in actual experience from people who’ve tried both.

Thanks boys

 

[Swedishsteel]

I got the new NMN, wich raise nad+ 10x higher then nmn n riboside. but its a shadow of a 100-200mg nad+ injection

 

[Nflz63]

I got the new NMN, wich raise nad+ 10x higher then nmn n riboside. but its a shadow of a 100-200mg nad+ injection

Where did you buy it ?

 

[Swedishsteel]

Where did you buy it ?

the oral? china

 

[nullandvoid]

Injectable NAD+ just gives me kind of an anxious energy and that's it. Not even a kind of energy that was usable in the gym. I was already on sublingual NMN's for quite some time, so I just always figured my NAD pool was already topped off. Not sure if IV would be on another level as you put it, but I found subcutaneous not worth it in my case. Still have nearly a whole kit of it. The NMN's are good enough for me. I think a lot is driven by marketing and greed, as usual. Look at all the clinics that have sprung up. They aren't doing it to be nice.

 

[Swedishsteel]

Injectable NAD+ just gives me kind of an anxious energy and that's it. Not even a kind of energy that was usable in the gym. I was already on sublingual NMN's for quite some time, so I just always figured my NAD pool was already topped off. Not sure if IV would be on another level as you put it, but I found subcutaneous not worth it in my case. Still have nearly a whole kit of it. The NMN's are good enough for me. I think a lot is driven by marketing and greed, as usual. Look at all the clinics that have sprung up. They aren't doing it to be nice.

NAD demands methyl donors and potassium for the creation of the new cells, this is why you feel anxious

 

[nullandvoid]

I have plenty of both, though. I take TMG and strictly control electrolytes to include taking Potrate 1080mg.

 

[Swedishsteel]

I have plenty of both, though. I take TMG and strictly control electrolytes to include taking Potrate 1080mg.

TMG is enough, but 1000mg potassium (i assume the potrate you wrote is) could be to low, do 2-3 grams and it should sort itself out. 4g per day is minimum RDA or what its called. i notice zero effect ot potassium under 2-3 grams

 

[Nidus]

I'd be careful supplementing Potassium in grams, you should be able to easily cover it all through normal food intake.

Even more reason to be cautious is when on a sartan, no need to artificially fuck around with your heart by adding huge amounts of potassium.

That stuff is really dangerous and should be done based on lab work when you have an actual deficiency too

 

[nullandvoid]

I'd be careful supplementing Potassium in grams, you should be able to easily cover it all through normal food intake.

Even more reason to be cautious is when on a sartan, no need to artificially fuck around with your heart by adding huge amounts of potassium.

That stuff is really dangerous and should be done based on lab work when you have an actual deficiency too

It's not supplemented on a whim. My diet is very tightly controlled, and I do not eat many vegetables. I absolutely hate them. I have all micros and macros on lockdown, and the Potrate helps me keep my K:Na ratio in proper range. The same goes for Sodium. Very little is obtained through diet, so I actually take salt tablets to supplement. I will eat potatoes and dynamically adjust my Potrate on the days I eat them. I also get very frequent labs and watch serum Potassium especially due to the Telmisartan.

 

[Swedishsteel]

I'd be careful supplementing Potassium in grams, you should be able to easily cover it all through normal food intake.

Even more reason to be cautious is when on a sartan, no need to artificially fuck around with your heart by adding huge amounts of potassium.

That stuff is really dangerous and should be done based on lab work when you have an actual deficiency too

Its prob the nr1 mineral except magnesium we are severly deficiant in. if you drink caffine you will flush your minerals out. the food you eat contain minimal amounts. if you work out your intake needs dramatically increase just like it do with magnesium n salt

Using steroids needs potassium as a cofactor for creation of new cells, being deficiant in it just like methyl donors is horrible for your organism. getting few 100mgs from food isent enough.

"my potatos contain potassium im fine" - Yeah how is it going with restoring high blood pressure with potatos, wont work

High blood pressure is potassium deficiancy. yet everyone got it

 

[Rawlifter198]

I’ve run both NMN and NAD+ and they felt very different for me.

NMN:

The biggest thing I noticed was a very clean, steady type of energy. Not stimulating, not edgy, just more consistent throughout the day. Recovery also seemed better. On nights where I only got around five hours of sleep, I often felt closer to how I normally would after seven. Nothing dramatic, but enough to notice. Mentally I felt a bit sharper too. Overall it was subtle but very “functional” if that makes sense.



NAD+:

Completely different experience. The best way I can describe it is like drinking a strong espresso. There was definitely an energy bump shortly after, but it was not smooth. It felt fast, almost jittery, and occasionally slightly anxiety-provoking. I also got headaches from it a few times.

I experimented with doses from about 50 mg up to 150 mg. At 150 mg I had a tight chest, racing heart, and it was honestly pretty uncomfortable. That was enough for me to realize more is not better with this compound. Personally I would not go above 100 mg again.

One thing that is probably relevant here is methylation.

NAD metabolism relies heavily on methyl donors because when your body processes nicotinamide, it has to be methylated so it can be safely cleared. If you already have reduced methylation capacity, this pathway can get strained. When that happens, some people experience symptoms that feel very “overstimulated” such as:

• anxiety or wired feeling


• headaches


• elevated heart rate


• blood pressure changes


• chest tightness


People with variants affecting methylation often have a smaller buffer for large NAD pushes, which is why slower precursors sometimes feel better tolerated.

That is one of the reasons NMN may feel smoother for certain individuals. It feeds the NAD pool more gradually instead of forcing a rapid spike, so it tends to create less metabolic stress.

Age may also play a role. NAD levels naturally decline over time, so people closer to their 40s, 50s, and beyond often report more noticeable benefits simply because they are correcting a larger deficit. If you are in your early 30s and already metabolically healthy, the ceiling for improvement is smaller.

Genetics absolutely matter too. Supplement responses are not universal, and NAD is a perfect example of that.

At this point I am not sure whether I will continue using NAD+. For me, NMN delivered more usable benefits with fewer side effects. NAD+ was not terrible, but it definitely did not live up to the hype in my case.