I use dudasteride to prevent hair loss, but I heard that using dudasteride with nandrolone can worsen hair loss. Is this true?
Nandrolone is normally converted by 5α‑reductase into 5α‑dihydronandrolone (5α‑DHN), which is a much weaker androgen in skin and hair follicles than nandrolone itself.
Dutasteride strongly inhibits both type 1 and type 2 5α‑reductase, cutting serum and tissue DHT by roughly 90–95%, and is very effective for androgenetic alopecia when used with testosterone‑based physiology. With nandrolone, that same 5α‑reductase block prevents conversion to 5α‑DHN, leaving a higher fraction of parent nandrolone, which is more androgenic at the follicle than 5α‑DHN and in this special case can increase skin/scalp androgenicity compared to nandrolone without a 5α‑reductase inhibitor.
Im highly averse to 5α‑reductase inhibitors. Dutasteride is like using a grenade to cut your fingernails. Total overkill. Downstream, DHT turns into very important hormones responsible for a myriad of essential functions, critical for health.
I would resort to minoxidil topical with retinoic acid, and a ketoconazole shampoo with microneedling. If that doesnt work, I would stack a topical dutasteride.
If that doesnt work, lower your AAS doses.
If that doesnt work, try oral dutasteride, but once every ten days on top of topical dut and mino.
If that doesnt work, shave it off.
