Nandrolone with Dutasteride?

[Var4theHuzz]

Effects vs without and if it is a good idea to use.
I have RU for hair and Accutane for acne.
This would in theory prevent conversion into DHN and preserve nandrolones anabolicity by preventing the convesrion
Has anyone used this?
Thank you

 

[BP_6]

Effects vs without and if it is a good idea to use.
I have RU for hair and Accutane for acne.
This would in theory prevent conversion into DHN and preserve nandrolones anabolicity by preventing the convesrion
Has anyone used this?
Thank you

Dhydronandrolone is actually a rather weak androgen. That is one thing that is unique about it. Normally the 5 alpha reductase enzyme makes something more androgenic, but in the case of nandrolone it is the opposite.

DHN is not likely going to be an issue for hair loss. At least compared to everything else.

 

[Var4theHuzz]

Dhydronandrolone is actually a rather weak androgen. That is one thing that is unique about it. Normally the 5 alpha reductase enzyme makes something more androgenic, but in the case of nandrolone it is the opposite.

DHN is not likely going to be an issue for hair loss. At least compared to everything else.

I read that it is also a lot less anabolic compared to Nandrolone so would inhibiting its conversion in a stack therefore increase the anabolicity of NPP/Deca?
I read that an estimated 20-40% is converted so would this not create a significant boost to the cycle?

 

[null88]

Using a 5-ARI with nandrolone would in theory increase its androgenicity probably keep the same level of anabolism, I don't think there is any human clinical data measuring this though. 5-AR is expressed inside the cell of certain tissues (skin, prostate, brain,..etc) so when nandrolone is converted to DHN, it should reduce AR signaling in those tissues. Muscle tissue has very little 5-AR, so the muscle building effects of nandrolone shouldn't really be affected if taking a 5-ARI. Of course given enough AAS, you will fully saturate the 5-AR.

 

[Sicsemptyran]

I read that it is also a lot less anabolic compared to Nandrolone so would inhibiting its conversion in a stack therefore increase the anabolicity of NPP/Deca?
I read that an estimated 20-40% is converted so would this not create a significant boost to the cycle?

As @null369 mentioned, you mostly just get more androgenic effects, not really an anabolic boost. The nandrolone just won't convert to DHN in the tissues with high 5AR (NOT MUSCLE), so it will be a stronger androgen in things like the skin/prostate/brain as he calls out.

You may theoretically get more nandrolone floating around to be used by the muscle because it's not being converted into DHN in those tissues, but you're talking about on the margins. Mostly just higher androgenicity.

For what it's worth, I ran NPP for a bit with dutasteride just because I take dutasteride to begin with and was pretty underwhelmed in general.

 

[Var4theHuzz]

Using a 5-ARI with nandrolone would in theory increase its androgenicity probably keep the same level of anabolism, I don't think there is any human clinical data measuring this though. 5-AR is expressed inside the cell of certain tissues (skin, prostate, brain,..etc) so when nandrolone is converted to DHN, it should reduce AR signaling in those tissues. Muscle tissue has very little 5-AR, so the muscle building effects of nandrolone shouldn't really be affected if taking a 5-ARI. Of course given enough AAS, you will fully saturate the 5-AR.

As @null369 mentioned, you mostly just get more androgenic effects, not really an anabolic boost. The nandrolone just won't convert to DHN in the tissues with high 5AR (NOT MUSCLE), so it will be a stronger androgen in things like the skin/prostate/brain as he calls out.

You may theoretically get more nandrolone floating around to be used by the muscle because it's not being converted into DHN in those tissues, but you're talking about on the margins. Mostly just higher androgenicity.

For what it's worth, I ran NPP for a bit with dutasteride just because I take dutasteride to begin with and was pretty underwhelmed in general.

Okay, thank you. This has been very helpful

 

[marsupial]

OP prove to me you’re not a looksmaxer part of clavicular’s cult

 

[Var4theHuzz]

OP prove to me you’re not a looksmaxer part of clavicular’s cult

Clavicular is a retard, I just care enough about my hair and acne to have those measures in place.

 

[brutalbxx]

OP prove to me you’re not a looksmaxer part of clavicular’s cult

bro is name it s

Var4theHuzz what u think?​

 

[james13]

Dhydronandrolone is actually a rather weak androgen. That is one thing that is unique about it. Normally the 5 alpha reductase enzyme makes something more androgenic, but in the case of nandrolone it is the opposite.

DHN is not likely going to be an issue for hair loss. At least compared to everything else.

As you know: nandrolone is normally converted by 5α‑reductase into 5α‑dihydronandrolone (5α‑DHN), which is a much weaker androgen in skin and hair follicles than nandrolone itself.
Dutasteride strongly inhibits both type 1 and type 2 5α‑reductase, cutting serum and tissue DHT by roughly 90–95%, and is very effective for androgenetic alopecia when used with testosterone‑based physiology. With nandrolone, that same 5α‑reductase block prevents conversion to 5α‑DHN, leaving a higher fraction of parent nandrolone, which is more androgenic at the follicle than 5α‑DHN and in this special case can increase skin/scalp androgenicity compared to nandrolone without a 5α‑reductase inhibitor.

Im highly averse to 5α‑reductase inhibitors. Dutasteride is like using a grenade to cut your fingernails. Total overkill. Downstream, DHT turns into very important hormones responsible for a myriad of essential functions, critical for health.
I would resort to minoxidil topical with retinoic acid, and a ketoconazole shampoo with microneedling. If that doesnt work, I would stack a topical dutasteride.
If that doesnt work, lower your AAS doses.
If that doesnt work, try oral dutasteride, but once every ten days on top of topical dut and mino.
If that doesnt work, shave it off.

 

[IceSkates]

OP prove to me you’re not a looksmaxer part of clavicular’s cult

Clavicular basically advises blasting Dutasteride because he says DHT is a terrible and the male body doesn't need it.

 

[james13]

Clavicular basically advises blasting Dutasteride because he says DHT is a terrible and the male body doesn't need it.

Dihydrotestosterone (DHT) is the most potent endogenous androgen at the androgen receptor in many tissues and is essential for male sexual differentiation, sexual function, some aspects of muscle and fat metabolism, and CNS signaling via its neurosteroid metabolites. Its downstream 5α‑reduced metabolites—especially 3α-androstanediol, 3β-androstanediol, androsterone, and etiocholanolone—have important androgenic and non‑androgenic actions, particularly in the brain as neurosteroids modulating GABAsubA and ERβ signaling.
Collectively, DHT and its 5α‑reduced diols exert neuroprotective and promyelinating actions, influence neurotransmission and seizure thresholds, and likely mediate a large fraction of testosterone/DHT’s mood, cognition, and stress‑buffering effects in the CNS.
I cannot empasize enough how important DHT is for overall health.
Too much and too little is bad news. Bad news.

 

[IceSkates]

Dihydrotestosterone (DHT) is the most potent endogenous androgen at the androgen receptor in many tissues and is essential for male sexual differentiation, sexual function, some aspects of muscle and fat metabolism, and CNS signaling via its neurosteroid metabolites. Its downstream 5α‑reduced metabolites—especially 3α-androstanediol, 3β-androstanediol, androsterone, and etiocholanolone—have important androgenic and non‑androgenic actions, particularly in the brain as neurosteroids modulating GABAsubA and ERβ signaling.
Collectively, DHT and its 5α‑reduced diols exert neuroprotective and promyelinating actions, influence neurotransmission and seizure thresholds, and likely mediate a large fraction of testosterone/DHT’s mood, cognition, and stress‑buffering effects in the CNS.
I cannot empasize enough how important DHT is for overall health.
Too much and too little is bad news. Bad news.

I know. Can't imagine how many young men Clavicular has duped into nuking their DHT.

 

[the_pope]

I'm sorry, but the fearmongering around finasteride and dutasteride is unsubstantiated. Both have been studied to death, so far no study has been able to prove the so-called "post-finasteride syndrome". It's probably more of a psychological thing than anything due to reading other people fearmongering online.

The supposed DHT and it's metabolites' neurological protections have only been seen in an animal study. We know for a fact that the people who are born with 5-alpha reductase deficiency go through puberty too, testosterone alone provides normal increases in muscle mass and a normal libido. And there is no record of any significant neurological damage suffered by them due to never having DHT at all. There is also the fact that none of the ton of studies on fina has found anything significant on suppossed neurological damage either.

Effects vs without and if it is a good idea to use.
I have RU for hair and Accutane for acne.
This would in theory prevent conversion into DHN and preserve nandrolones anabolicity by preventing the convesrion
Has anyone used this?
Thank you

To answer the original, very reasonable, question: DHN is very hair friendly, using a 5-alpha blocker will prevent nandrolone from metabolizing into DHN, which means some other more androgenic compound might get your hair follicles.

I'd say that if your nandrolone dose is higher than your test dose, you should stop and clear duta before starting nandrolone. But if your test dose is going to be higher, it's probably worth it to block DHT. Eg, if your cycle is 300 test 600 deca, avoid duta. But if it is 600 test 300 deca, take it. This is just my personal opinion on the matter, I hope that makes sense.

The fact that you are taking RU-58841 makes this problem completely vanish, tho. AFAIK, RU is an anti-androgen that will prevent any androgen (be it DHN, DHT, nandrolone or any other) from adhering to your hair follicles. It is also local action (topical), so it will not block androgens working on the rest of your system, eg prostate. So no matter the androgens in your body, RU-58841 will prevent them from affecting your follicles.

 

[james13]

I'm sorry, but the fearmongering around finasteride and dutasteride is unsubstantiated. Both have been studied to death, so far no study has been able to prove the so-called "post-finasteride syndrome". It's probably more of a psychological thing than anything due to reading other people fearmongering online.

The supposed DHT and it's metabolites' neurological protections have only been seen in an animal study. We know for a fact that the people who are born with 5-alpha reductase deficiency go through puberty too, testosterone alone provides normal increases in muscle mass and a normal libido. And there is no record of any significant neurological damage suffered by them due to never having DHT at all. There is also the fact that none of the ton of studies on fina has found anything significant on suppossed neurological damage either.


To answer the original, very reasonable, question: DHN is very hair friendly, using a 5-alpha blocker will prevent nandrolone from metabolizing into DHN, which means some other more androgenic compound might get your hair follicles.

I'd say that if your nandrolone dose is higher than your test dose, you should stop and clear duta before starting nandrolone. But if your test dose is going to be higher, it's probably worth it to block DHT. Eg, if your cycle is 300 test 600 deca, avoid duta. But if it is 600 test 300 deca, take it. This is just my personal opinion on the matter, I hope that makes sense.

The fact that you are taking RU-58841 makes this problem completely vanish, tho. AFAIK, RU is an anti-androgen that will prevent any androgen (be it DHN, DHT, nandrolone or any other) from adhering to your hair follicles. It is also local action (topical), so it will not block androgens working on the rest of your system, eg prostate. So no matter the androgens in your body, RU-58841 will prevent them from affecting your follicles.

What a weird hill to die on. DHT is critical for masculinization of external genitalia, so affected 46,XY individuals often have ambiguous or female-appearing genitalia at birth (micropenis, hypospadias, bifid scrotum, blind vaginal pouch, etc.)